Navigation Links
Depression Heightens Sensitivity to Pain
Date:11/7/2008

MRI reveals relationship between mental condition and reaction to physical discomfort

FRIDAY, Nov. 7 (HealthDay News) -- When anticipating pain, the brains of people with depression kick into overdrive and hinder their ability to handle hurt, a new study shows.

The November issue of the Archives of General Psychiatry reports brain imaging also reveals that during the painful experience, activity then decreases in other areas, including those regions that handle pain modulation.

"The anticipatory brain response may indicate hypervigilance to impending threat, which may lead to increased helplessness and maladaptative modulation during the experience of heat pain," the authors wrote. "This mechanism could in part explain the high comorbidity of pain and depression when these conditions become chronic."

Chronic pain and depression often overlap, the authors wrote. More than 75 percent of depression patients have recurring or chronic pain, while between 30 percent and 60 percent of chronic pain patients also report symptoms of depression.

"Understanding the neurobiological basis of this relationship is important, because the presence of comorbid pain contributes significantly to poorer outcomes and increased cost of treatment in major depressive disorder," they wrote.

The research team, from the University of California, San Diego, in La Jolla, studied 30 adults, half with a major depressive disorder but not on medication for the condition and half without it. All wore devices that could heat their arms to painful levels, and all were given visual signals before the exercise as to whether they would feel painful heat or a more mild warmth.

The patients with depression also completed a questionnaire about their tendencies to magnify, ruminate over or feel helpless in the face of pain.

Compared with the controls, patients with depression showed increased activation in certain areas of their brain, including the right amygdala -- a brain region tied to emotional responses. This increased activity also correlated to higher helplessness scores on the questionnaires of the patients with depression.

"Future studies that directly examine whether maladaptive response to pain in major depressive disorder is due to emotional allodynia [a pain response to a non-painful stimulus], maladaptive control responses, lack of resilience and/or ineffectual recruitment of positive energy resources will further our understanding of pain-depression comorbidity," the authors concluded.

More information

The U.S. National Institute of Health has more about depression.



-- Kevin McKeever



SOURCE: JAMA Archives journals, news release, Nov. 3, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Study Demonstrates Cost Effectiveness of NeuroStar TMS Therapy(R) in the Treatment of Depression
2. Integrative Medicine Pioneer To Host Free Groundbreaking Web Series on a Natural Approach for Treating Depression
3. Black Heart Patients Treated Less for Depression
4. Older Diabetics With Depression Face Higher Death Rate
5. FDA Clears NeuroStar(R) TMS Therapy for the Treatment of Depression
6. Many Military Installations Worldwide Participate in National Depression Screening Day
7. Getting help for depression and anxiety has significant long-term benefits
8. Adolescent insomnia linked to depression and substance abuse during adolescence and young adulthood
9. Personality can hamper a physicians assessment of depression
10. Family therapy helps relieve depression symptoms in bipolar teens
11. Depression common among Rwandan youth who head households
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Depression Heightens Sensitivity to Pain
(Date:8/19/2017)... ... ... Yesterday, the President of the United States retracted his condemnation of white ... two sides to hatred, bigotry, discrimination, and a white supremacy nationalist agenda. That ... all forms of such hatred and discrimination in this country and globally. ...
(Date:8/19/2017)... ... ... “Congratulations! It's A Boy! God’s Gift: A Story of Love”: a children’s book ... A Boy! God’s Gift: A Story of Love” is the creation of published authors, ... by Christian Faith Publishing, Dale Anthony and Rachael Anthony’s new book is a perfect ...
(Date:8/18/2017)... ... ... ... For Immediate Release                Contact: Julian ... Young Women Seek Sex and Relationship Advice from their Fathers ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... edition of “Vision & Hearing,” advocating for active, healthy lifestyles and highlighting the ... available for individuals with hearing impairments and shares the latest innovations in hearing ...
(Date:8/18/2017)... ... ... The Dawn Johnson Insurance Group, a Missouri-based insurance and financial planning firm ... for efforts to educate the local population on cancer realities while attracting donations to ... , Each day in America, roughly 4,600 new cases of cancer are diagnosed and ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... GAITHERSBURG, Md. , Aug. 7, 2017 /PRNewswire/ ... for healthcare member acquisition, retention, and engagement, announced ... Director of Strategy and Product Development, effective as ... strategic consulting and technology implementation strategy for our ... years of experience in consulting and business analytics ...
(Date:8/4/2017)... , Aug. 4, 2017 The search for ... after a physician/patient consult has long been the goal ... a notable focus of the largest meeting of lab ... to healthcare market research firm Kalorama Information.  The firm ... (POCT) offerings or related supplies and software were at ...
(Date:8/2/2017)... AURORA, Ore. , Aug. 2, 2017  Life Flight ... Call Agreement. The agreement improves patient care and operational efficiency ... Springfield , Cottage Grove ... ICU level medical transportation. PeaceHealth and Life Flight Network work ... care available during transport, or when a time sensitive emergency ...
Breaking Medicine Technology: