Navigation Links
Depression Heightens Sensitivity to Pain

MRI reveals relationship between mental condition and reaction to physical discomfort

FRIDAY, Nov. 7 (HealthDay News) -- When anticipating pain, the brains of people with depression kick into overdrive and hinder their ability to handle hurt, a new study shows.

The November issue of the Archives of General Psychiatry reports brain imaging also reveals that during the painful experience, activity then decreases in other areas, including those regions that handle pain modulation.

"The anticipatory brain response may indicate hypervigilance to impending threat, which may lead to increased helplessness and maladaptative modulation during the experience of heat pain," the authors wrote. "This mechanism could in part explain the high comorbidity of pain and depression when these conditions become chronic."

Chronic pain and depression often overlap, the authors wrote. More than 75 percent of depression patients have recurring or chronic pain, while between 30 percent and 60 percent of chronic pain patients also report symptoms of depression.

"Understanding the neurobiological basis of this relationship is important, because the presence of comorbid pain contributes significantly to poorer outcomes and increased cost of treatment in major depressive disorder," they wrote.

The research team, from the University of California, San Diego, in La Jolla, studied 30 adults, half with a major depressive disorder but not on medication for the condition and half without it. All wore devices that could heat their arms to painful levels, and all were given visual signals before the exercise as to whether they would feel painful heat or a more mild warmth.

The patients with depression also completed a questionnaire about their tendencies to magnify, ruminate over or feel helpless in the face of pain.

Compared with the controls, patients with depression showed increased activation in certain areas of their brain, including the right amygdala -- a brain region tied to emotional responses. This increased activity also correlated to higher helplessness scores on the questionnaires of the patients with depression.

"Future studies that directly examine whether maladaptive response to pain in major depressive disorder is due to emotional allodynia [a pain response to a non-painful stimulus], maladaptive control responses, lack of resilience and/or ineffectual recruitment of positive energy resources will further our understanding of pain-depression comorbidity," the authors concluded.

More information

The U.S. National Institute of Health has more about depression.

-- Kevin McKeever

SOURCE: JAMA Archives journals, news release, Nov. 3, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Study Demonstrates Cost Effectiveness of NeuroStar TMS Therapy(R) in the Treatment of Depression
2. Integrative Medicine Pioneer To Host Free Groundbreaking Web Series on a Natural Approach for Treating Depression
3. Black Heart Patients Treated Less for Depression
4. Older Diabetics With Depression Face Higher Death Rate
5. FDA Clears NeuroStar(R) TMS Therapy for the Treatment of Depression
6. Many Military Installations Worldwide Participate in National Depression Screening Day
7. Getting help for depression and anxiety has significant long-term benefits
8. Adolescent insomnia linked to depression and substance abuse during adolescence and young adulthood
9. Personality can hamper a physicians assessment of depression
10. Family therapy helps relieve depression symptoms in bipolar teens
11. Depression common among Rwandan youth who head households
Post Your Comments:
Related Image:
Depression Heightens Sensitivity to Pain
(Date:10/13/2015)... Boulder, Colorado (PRWEB) , ... October 13, 2015 ... ... launched the first high-tech foam roller with 11 hours of vibrating power. Tested ... to reduce recovery time and increase athletic performance. , Mark's background in sporting ...
(Date:10/13/2015)... , ... October 13, 2015 , ... The American Institutes ... college campus health staff caring for students who have experienced sexual assault and other ... the White House during the Violence Against Women Act's 21st anniversary. ...
(Date:10/13/2015)... M.A. (PRWEB) , ... October 13, 2015 , ... Sir ... service to the local Boston chapter of Ronald McDonald House Charities® (RMHC®). This ... that has supported Sir Grout of Greater Boston since its inception. , “We believe ...
(Date:10/13/2015)... ... ... "My friend's son suffers from eczema, and he had a horrible habit ... Platteville, Colo. "I came up with this kit as a way to prevent children ... child from rubbing or scratching his or her face. This protects sensitive skin from ...
(Date:10/13/2015)... , ... October 13, 2015 , ... ... anesthesia and pain management services, today announced its partnership with WPC Healthcare ... data from disparate systems and organizes the data into an aggregated data repository ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... Oct. 13, 2015 Attracting mid- to large-sized medical ... to growing Baltimore into a major ... by the Maryland Technology Enterprise Institute (Mtech) . ... pieces in place to support innovation hubs and a thriving ... Mtech Baltimore. "This study is important because we believe ...
(Date:10/13/2015)... , Oct. 13, 2015  Graduate students ... care and medical research, will soon have the ... patient care – the drug discovery and development ... ) has collaborated with 10 leaders from academic ... "Making Medicines: The Process of Drug Development."  Lilly ...
(Date:10/13/2015)... SAN FRANCISCO , October 13, 2015 ... expected to reach USD 26.8 billion by 2022, according ... Anesthesia and respiratory devices, owing to their capability to ... expected to witness a substantial growth. --> ... reach USD 26.8 billion by 2022, according to a ...
Breaking Medicine Technology: