Navigation Links
Dense bones linked to raised risk for prostate cancer
Date:7/28/2010

Men who develop prostate cancer, especially the more aggressive and dangerous forms that spread throughout the body, tend to retain denser bones as they age than men who stay free of the disease, suggests new research from Johns Hopkins and the National Institute on Aging (NIA), part of the National Institutes of Health.

The finding, published in the July British Journal of Urology International, could help scientists gain a better grasp on what causes prostate cancer and its spread.

Researchers have long known that prostate cancers that spread, or metastasize, often migrate to bone. That idea led Stacy Loeb, M.D., a resident in the Department of Urology at the Johns Hopkins University School of Medicine, and her colleagues to wonder whether there is a connection between bone characteristics and prostate cancer development and metastasis.

"We reasoned there may be some difference between men who develop prostate cancer, especially metastatic disease, and those who don't, and it was logical to see if there was something different about their bones," says Loeb.

To investigate, she and her colleagues used data from the NIA's Baltimore Longitudinal Study of Aging , a long-term study that has tracked various health-related information for hundreds of Baltimore-area participants since 1958. The researchers collected data on the bone mineral density of 519 men, measured from 1973 to 1984. They then used the same collection of data to see which men were eventually diagnosed with prostate cancer.

Typically, bone density declines with age in both men and women. However, Loeb and her colleagues found that the 76 men in their study who went on to develop prostate cancer had bone density that remained significantly higher as they aged, compared with those who remained cancer free. The findings held up even after the researchers accounted for lifestyle factors that might influence bone density, such as smoking, body mass index, and intake of dietary calcium and vitamin D.

Further examination showed that the 18 men who developed the high-risk form of the disease retained the highest bone density, but the researchers caution that the number of patients is too small to make any final conclusions about bone features and metastatic disease.

Loeb and her colleagues say that their findings don't mean that bone density scans should be used as a screening tool for prostate cancer. Rather, their goal was to better understand the link between prostate cancer and bone. They say their results suggest that the same factors that influence bone density, such as sex hormones or growth factors in bone, may also be spurring prostate cancer to develop and metastasize. She and her colleagues plan to continue searching for what common factors connect bone density and prostate cancer in future studies.

"If we can elucidate the underlying pathways, we could develop strategies for preventing prostate cancer from occurring or spreading," Loeb says.


'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. Elemental bones
2. Scientists Find Way to Heal Broken Bones Faster
3. NIH study confirms location of stem cells near cartilage-rich regions in bones
4. With Anorexia, Body May Hoard Fat in Bones
5. Childhood sexual abuse and social shaming linked to health issues later
6. Homeopathic Nasal Zinc Linked to Loss of Smell
7. Behavior problems in school linked to 2 types of families
8. Excess Weight in Older Women Linked to Diminished Memory
9. Brain responses of obese individuals are more weakly linked to feelings of hunger
10. Fish Oil Supplements Linked to Lower Risk of Breast Cancer: Study
11. Glucosamine Ineffective for Lower Back Pain Linked to Arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... 04, 2016 , ... With the stamp of approval from the United States ... National Cancer Research Month. According to the American Cancer Society (2016) , this ... one in four Americans dying as a result. , With numbers as influential as ...
(Date:5/4/2016)... ... May 04, 2016 , ... Vasont ... Vasont Universal Integrator (VUI) extension supports the latest release of Adobe FrameMaker, Release ... 2015 interlace the process of creating, editing and storing XML. , ...
(Date:5/3/2016)... ... , ... ProIntro Glitch is a set of 30 self-animating glitch-themed intros created ... to add a terrifying opener to any video or media. Choose from unique styles ... greater contrast, all the user has to do is increase the turn on background ...
(Date:5/3/2016)... ... May 03, 2016 , ... Healing Cancer in This Century is ... move toward recovery and is offered by creator and visionary Carlos Caridad. Healing ... Radio show considering medical and healing modalities of the fields of Integrative, Alternative, ...
(Date:5/3/2016)... ... ... is now open for the 31st annual AIDS Walk Boston & 5K Run , ... Esplanade. The event regularly draws thousands of participants, making it AIDS Action Committee’s largest annual ... by the USA Track & Field Association. , The AIDS Walk & 5K Run ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... , May 3, 2016  Specialty Silicone Fabricators ... that shows how a cleanroom works. The free ... about science and technology. ... a technology company, SSF enthusiastically supports the Science, ... educators foster the next generation of innovators. We ...
(Date:5/3/2016)... , May 3, 2016 ... bekannt, dass sie einen entscheidenden Meilenstein durch ... Ein Aufruf zum Handeln, um Patientenresultate  bei ... trägt zu Fortschritten im Verständnis der Hepatischen ... ein Bewusstsein für Hepatische Enzephalopathie in der ...
(Date:5/2/2016)... Mass. , May 2, 2016  While nearly ... that osteoporosis can have on their health, only about ...   according to the results of a new survey ... To mark the start of National Osteoporosis Month, Hologic ... health, which affects nearly 56 million Americans. ...
Breaking Medicine Technology: