Navigation Links
Denosumab delays development of prostate cancer bone metastasis
Date:11/15/2011

432 participants at 319 centers in 30 countries all prostate cancer patients whose tumors had stopped responding to androgen-deprivation therapy and were metastasis-free, although rising PSA levels indicated they were at risk for metastasis.

Participants were randomly assigned to receive injections of either denosumab or a placebo every four weeks. During the two-year study period, patients were examined including a bone scan every four months, and X-ray skeletal surveys performed annually. If a bone scan indicated the presence of metastasis, it was confirmed with either X-ray, CT scan or MRI. After that confirmation, study treatment was discontinued, since other therapies are approved to treat metastatic prostate cancer.

Study results indicated that denosumab treatment increased bone-metastasis-free survival defined as the time to either the first metastasis or death from any cause by an average of more than four months, extended the time to first metastasis and delayed symptoms of metastasis. Biochemical markers indicated that denosumab treatment did reduce bone turnover. While there was no survival difference between the two study groups, the authors note that that fact that denosumab was discontinued when the first metastasis was diagnosed makes judging the drug's effects on survival difficult.


'/>"/>

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Denosumab delayed time to first skeletal-related side effect
2. Toronto researchers find first physical evidence bilingualism delays onset of Alzheimers symptoms
3. Folic Acid in Pregnancy May Prevent Kids Language Delays
4. New bone-targeting drug delays onset of metastases in hormone-resistant prostate cancer patients
5. Phase II study shows new cancer drug combination significantly delays breast cancer progression
6. Emergency treatment for heart attack improving but delays still occur
7. ADHD Drug Delays Puberty in Male Monkeys, Study Finds
8. One-Third of Severe Heart Attack Patients Have Treatment Delays
9. Many Pediatricians Arent Testing Tots for Developmental Delays
10. Hospital Delays Tied to Racial Divide in Heart Attack Care
11. Delays in Hospital Transfers for Heart Attack Patients May Raise Death Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... 4 Franklin & Seidelmann,( http://www.franklin-seidelmann.com ... into the hospital sector with the,addition of three new ... -- Barnes-Kasson Hospital, Susquehanna, PA, ... -- Syringa General Hospital, Grangeville, ID, ...
... Feb. 4 Pulse Systems announced today ... the International,Organization for Standardization (ISO) quality systems ... "Achievement of these highly-regarded ... contract manufacturing services to the,medical device industry, ...
... 4 Kensey Nash Corporation (Nasdaq: KNSY ), ... technologies for a wide range of medical procedures, today announced ... Manager of Ramius LLC, from its Board of Directors.Mr. Smith ... was a member of the Corporate Governance and Nominating Committee ...
... UK, 04 February 2009 The journal ... has announced the winner of the 2008 David Horrobin ... and Jan van der Linden from the Karolinska Institute ... the risk of surgical site infection" was judged to ...
... With counterfeit and adulterated medicines posing an increasing ... the U.S. Pharmacopeial (USP) Convention today announces new standards ... involved in episodes of adulteration resulting in patient deaths. ... blood thinner heparin and the sweetener glycerin, comes on ...
... Omega-3s EPA/DHA and 170% Daily Requirement of Vitamin EPARAMUS, N.J., ... ) today announced that it will launch Smart Balance(TM) Milk ... areas and New England during the first quarter of 2009. ... sold in Florida and Georgia, tastes rich and creamy, is ...
Cached Medicine News:Health News:Franklin & Seidelmann Expands into Critical Access Hospital Market Provides 24 x 7 Teleradiology Service for Three New Clients 2Health News:Franklin & Seidelmann Expands into Critical Access Hospital Market Provides 24 x 7 Teleradiology Service for Three New Clients 3Health News:Pulse Systems Receives Dual Certification Under ISO 13485:2003 and ISO 9001:2008 2Health News:Kensey Nash Announces Director Resignation 2Health News:USP announces new standards to protect patients from counterfeit and adulterated medicines 2Health News:Smart Balance to Bring Milk with More Taste and Less Fat to New York City and Albany Metro Areas and New England 2Health News:Smart Balance to Bring Milk with More Taste and Less Fat to New York City and Albany Metro Areas and New England 3
(Date:12/17/2014)... 2014 PCCA received the Autism Hope ... ) program seal for best practices in meeting ... medical practices, materials and goods that meet strict ... Children affected by autism often have unique physical ... ingredients found in food and medicine – for ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... the "Inferior Vena Cava (IVC) Filters - Global ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... projected to reach US$435 million by 2016. The ... (2015) of the global value while Europe ...
(Date:12/15/2014)... PLYMOUTH MEETING, Pa. , Dec. 15, 2014 ... ) announced today it has been added to ... the NASDAQ Biotechnology Index will become effective upon ... The NASDAQ Biotechnology Index is designed to track ... that are classified as either biotechnology or pharmaceutical ...
Breaking Medicine Technology:Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 4Inovio Pharmaceuticals Added to NASDAQ Biotechnology Index 2Inovio Pharmaceuticals Added to NASDAQ Biotechnology Index 3Inovio Pharmaceuticals Added to NASDAQ Biotechnology Index 4
... of Cervical Cancer and Other Human,Papillomavirus Related Diseases ... Phase III Clinical Studies Which Included More Than,17,000 ... the most comprehensive,and robust clinical data for any ... – New clinical study results,confirm the high and ...
... - Antisense,Pharma today announced, that the abstract entitled,“Preliminary ... Melanoma, and Colorectal Carcinoma with the,TGF-beta2 Inhibitor AP ... 43rd Annual Meeting of the American Society of,Clinical ... Illinois,U.S.A, from June 1st - 5th. , In ...
Cached Medicine Technology:Gardasil Demonstrates Up to 100% Efficacy 2Gardasil Demonstrates Up to 100% Efficacy 3Gardasil Demonstrates Up to 100% Efficacy 4Gardasil Demonstrates Up to 100% Efficacy 5Gardasil Demonstrates Up to 100% Efficacy 6Gardasil Demonstrates Up to 100% Efficacy 7Phase I/II-data on Systemic Application of the TGF-beta2-inhibitor,AP 12009 to be Presented 2
Tapered Shaft Microscissors : Williams Curved SharpTipped Scissors...
Disposable Microscissors: Horizontal, Curved...
Disposable Microscissors: Horizontal, Straight...
Disposable Microscissors: Vertical, 90...
Medicine Products: