Navigation Links
Denosumab delayed time to first skeletal-related side effect
Date:12/10/2010

SAN ANTONIO For patients with breast cancer and bone metastases, denosumab delayed skeletal-related side effects five months longer compared to those on zoledronic acid, according to results presented at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 8-12.

"The average life expectancy of patients with metastatic breast cancer is approximately 2.5 years, so if you can prolong the time without a skeletal-related event by five months, you are substantially benefiting the patient," said Alison T. Stopeck, M.D., associate professor of medicine and director of the Clinical Breast Cancer Program at the Arizona Cancer Center, University of Arizona, Tucson.

The Food and Drug Administration approved denosumab, sold by Amgen as XGEVA starting Nov. 18, 2010, for the prevention of skeletal-related events in patients with bone metastases from solid tumors.

Previous results from this Phase III trial indicated that denosumab was superior to zoledronic acid in delaying the time to first on-study, skeletal-related side effects, such as fracture, radiation to bone, surgery to bone or spinal cord compression in patients with breast cancer and bone metastases. These results detail an additional four months of blinded treatment.

Stopeck and colleagues randomized 2,046 patients with advanced breast cancer to receive either 120 mg of subcutaneous denosumab or 4 mg of intravenous zoledronic acid every four weeks. Both of these drugs inhibit osteoclasts, or the cells that break down bone, therefore, all patients took calcium and vitamin D daily.

Denosumab was better at delaying the time to first on-study, skeletal-related event by 18 percent and the time to first and subsequent event by 22 percent. The median time to first on-study, skeletal-related event was five months longer for the denosumab group compared to the zoledronic acid group.

Overall survival and disease progression was similar for both grou
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pain Relief Often Delayed for Cancer Patients
2. Delayed retirement among Americans may bolster future of Social Security and Medicare, study finds
3. $18.5 Million New Jersey Medical Malpractice Birth Injury Verdict Due To Cerebral Palsy Caused By A Delayed C-Section
4. New study confirms positive effects of delayed school start times
5. For HIV-positive patients, delayed treatment a costly decision
6. Medical Training School, Pima Medical Institute Offering First Bachelor's Degree Program
7. Retired Military Brass Support First Ladys Call to Reduce Child Obesity, Improve Nutrition
8. NASBE Supports First Lady Michelle Obama in Fight Against Childhood Obesity
9. PolicyLink CEO Angela Glover Blackwell Released the Following Statement on First Lady Michelle Obamas Childhood Obesity Initiative
10. MSU launches first anti-counterfeiting research program
11. AMA Joins First Lady in Fight Against Childhood Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... 01, 2014 Top10BestSEOHosting.com has recently ... web host suppliers carefully, Top10BestSEOHosting.com is here to ... best web hosting suppliers in 2014. , JustHost ... with a top-of-the-line shared hosting plan. The company’s ... platform that is affordable, accessible and powerful enough ...
(Date:9/1/2014)... (PRWEB) September 01, 2014 Pastor Thompson is ... Specialist at Eagle Village. He is a licensed minister through ... over the past twenty years in New Mexico, Colorado and ... years of marriage this year. He also has two ... a B.S. in Pastoral Ministry from Nazarene Bible College, in ...
(Date:8/31/2014)... 2014 An analysis of 32 studies ... revealed a link between lower levels of Vitamin D ... the August 2014 issue of American Journal ... form of Vitamin D found in blood. , ... D lower than 9 nanograms/milliliter (ng/mL) were twice as ...
(Date:8/31/2014)... GoDaddy, IX Web Hosting and Bluehost are ... Server) hosting, which is the method of partitioning ... of which has the appearance and capabilities of ... recently compared many professional web hosting suppliers and ... VPS hosting suppliers in the global market. , ...
(Date:8/31/2014)... of hard work, Delta has now become one of the ... has updated its wheel loader assortment with a ... are guaranteed to be great. Additionally, they are offered at ... that all items in Delta’s used cat 966 loader ... is making full efforts to help worldwide customers to get ...
Breaking Medicine News(10 mins):Health News:Why Top10BestSEOHosting.com Calls Them Great Web Hosting Suppliers 2Health News:NutriGold Highlights New Study on the Importance of Vitamin D to Our Life Span 2Health News:NutriGold Highlights New Study on the Importance of Vitamin D to Our Life Span 3Health News:NutriGold Highlights New Study on the Importance of Vitamin D to Our Life Span 4Health News:GoDaddy, IX Web Hosting and Bluehost Are Awarded As Hosting Experts by Top10BestSEOHosting.com 2Health News:Delta Updates Its Wheel Loader Assortment With A Lot Of Cheap Used Cat 966 Loaders 2
... Professor Lewis Glinert and Jon Schommer, the associate head ... at the University of Minnesota, have examined the corporate ... found a startling lack of consistency in an industry ... Drug Administration (FDA). "Communicating via a website ...
... ... sunscreen provides broad spectrum protection for skin from the sun,s harmful rays. , ... (PRWEB) June 30, 2010 ... is introducing a non-chemical natural sunscreen armed with unparalleled protection, barely-there feel, ...
... complete cascade of signals within breast tumour cells activated by ... the activity of the oncogene p21Ras, changes in protein signaling ... damage. The study was carried out in an experimental model ... cell lines. Breast cancer is the most common ...
... ... Channel® continue to beat expectations , , ... (PRWEB) June 30, 2010 -- Healing HealthCare Systems (HHS) based ... growth and consistent demand for its industry-leading product, The C.A.R.E. Channel , evidence-based relaxation ...
... , ... face an increasingly complex landscape of breach notification requirements for protected health information (PHI). ... pressing entities to notify within 60 days of discovery. Kroll’s expanded data breach solutions ... continuum. , ...
... ... and language competency. , ... UK (PRWeb UK) June 30, 2010 -- HCL plc, one of the UK’s leading health ... a review of the processes which overseas doctors must undergo before they can ...
Cached Medicine News:Health News:Linguistics professor examines manufacturers' prescription drug websites 2Health News:As Summer Heats Up, Glacier Creme Debuts the Ultimate in Natural Sunscreen: 'Naked Protection' with Zinc Oxide 2Health News:A key mechanism links virgin olive oil to protection against breast cancer 2Health News:High Customer Retention and Continual Product Demand Drive Steady Growth for Innovative Healthcare Company 2Health News:Kroll Fraud Solutions' New HITECH Hotline Eases Burden of Data Breach Notification for Healthcare 2Health News:Kroll Fraud Solutions' New HITECH Hotline Eases Burden of Data Breach Notification for Healthcare 3Health News:Kroll Fraud Solutions' New HITECH Hotline Eases Burden of Data Breach Notification for Healthcare 4Health News:HCL Supports Reform of Language Testing for International Doctors 2Health News:HCL Supports Reform of Language Testing for International Doctors 3
(Date:8/29/2014)... 29, 2014 Pomerantz LLP has filed a ... "Company") (NASDAQ: EDAP ) and certain of ... District Court, Southern District of New York ... of a class consisting of all persons or entities ... July 30, 2014, inclusive (the "Class Period"). This class action ...
(Date:8/29/2014)... WEST JORDAN, Utah , Aug. 29, 2014 /PRNewswire/ ... Imaging Solutions, has acquired Polaris Medical Imaging, a leader ... CT scanners. This strategic acquisition allows BC Technical to ... their capabilities, specifically within MR and CT modalities. ... lower cost service," said Mark Alvarez , president ...
(Date:8/29/2014)... -- Does your doctor know what you,re smoking?  Chances are, ... to the over 112,000 currently registered patients under ... other roughly 20,300+ active physicians listed with the Colorado Dept ... even though a poll in February 2014 showed 51% of ... it. "With marijuana legalization underway, every doctor ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against EDAP TMS S.A. and Certain Officers - EDAP 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against EDAP TMS S.A. and Certain Officers - EDAP 3BC Technical Acquires Polaris Medical Imaging 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: