Navigation Links
Dendritic cells protect against acute pancreatitis
Date:11/22/2011

NYU Langone Medical Center researchers have discovered the novel protective role dendritic cells play in the pancreas. The new study, published in the November issue of journal Gastroenterology, shows dendritic cells can safeguard the pancreas against acute pancreatitis, a sudden dangerous swelling and inflammation of the pancreas gland.

"Our study findings demonstrate that an abundance of dendritic cells are needed in the pancreas for normal, healthy pancreatic function, especially when there are high levels of inflammation caused by acute pancreatitis," said senior author George Miller, MD, assistant professor, Departments of Surgery and Cell Biology at NYU Langone Medical Center. "The study shows that dendritic cells can alleviate cellular stress caused by severe inflammation."

In the new study, researchers found high levels of dendritic cells in the pancreas can protect the organ from acute pancreatitis damage while low levels of dendritic cells in the pancreas are associated with exacerbated pancreas injury including pancreatic necrosis, complete pancreas cell and tissue death.

The pancreas is a vital hormone and enzyme-producing gland assisting in the human body's digestion and absorption of food. However, the gland can become inflamed leading to acute pancreatitis, a serious and potentially life-threatening condition, severe cases can lead to pancreatic necrosis. Its two percent overall mortality rate jumps to 10 to 30 percent in patients with pancreatic necrosis. The disorder results in 200,000 hospital admissions and two billion dollars annually in medical expenses in the United States.

Pancreatitis can be acute or chronic, developing over time. It's caused by gallstones, alcohol abuse, or medications. Symptoms include abdominal pain, nausea and vomiting, and current treatments include hospitalization, medication, restricted diet or surgery. Pancreatitis can be reduced or prevented with removal of the gall bladder, limiting alcohol intake or prescription medication.

Dendritic cells in the body have emerged as important cellular mediators of inflammation. Previous studies by NYU Langone researchers and others have shown the ability of dendritic cells in the body to suppress inflammation in a number of organ-specific inflammatory conditions including liver injury. Upon exposure to inflammation, dendritic cells suppress inflammation by activating an immune response. However, the cellular regulation of acute pancreatitis was not completely understood until now.

In the new study, researchers induced mice models with acute pancreatitis. As a result, the level of dendritic cells in the pancreas increased by two-fold. This observation identified the innate immune system response of dendritic cells to the excessive swelling and inflammation of the pancreas gland. In addition, researchers tested the effects of dendritic cell depletion in acute pancreatitis mice models. Their experiments showed mice with depleted dendritic cell levels developed pancreatic necrosis and died within four days. Dendritic cell depletion was also associated with a higher infiltration of white blood cells and inflammation markers. The negative effects of dendritic cell depletion experiments show the critical protective role these cells play in pancreatic organ survival.

"We now have a greater understanding of dendritic cells, the key cellular mediators of inflammation, during dangerous acute pancreatitis. These cells play a central role in acute pancreatitis and are required for the pancreas' viability," said Dr. Miller, a member of the NYU Cancer Institute. "Our novel findings show depletion of dendritic cells result in the massive increase in severe pancreas inflammation, injury and organ destruction. We are now one step closer to more effective treatments for this harmful human condition."

The study suggests dendritic cells in the pancreas as new therapeutic targets for reducing any cellular stress on the pancreas from pancreatitis. Further research is needed to elucidate dendritic cell function and develop an immune-directed therapy against acute pancreatitis.


'/>"/>

Contact: Lauren Woods
lauren.woods@nyumc.org
212-404-3555
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Related medicine news :

1. A first -- lab creates cells used by brain to control muscle cells
2. Molecules on branched-polymer surfaces can capture rare tumor cells in blood
3. New heart cells increase by 30 percent after stem cell infusion
4. Stem Cells Show Promise in Healing Damaged Hearts
5. Fetal stem cells from placenta may help maternal heart recover from injury
6. Scientists discover how to design drugs that could target particular nerve cells
7. Obese monkeys lose weight on drug that attacks blood supply of fat cells
8. Neurological disorder impacts brain cells differently
9. Autistic Children May Have Too Many Brain Cells
10. Study identifies an expanded role for PKM2 in helping cancer cells survive
11. UCLA researchers identify brain cells responsible for keeping us awake
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... , ... May 24, 2017 , ... Myers Jackson is ... has the ability to sell luxury homes anywhere on the planet. The luxury home ... side from Hattiesburg to Houston city-scapes. A quick search of “11 Spyglass Hill Auction ...
(Date:5/24/2017)... ... May 24, 2017 , ... Accordant Technology, a ... portfolio. ExtraHop delivers an analytics-first approach, layered with machine learning, that provides real-time ... datacenter to the cloud to the edge. Through the new partnership, customers get ...
(Date:5/24/2017)... ... 24, 2017 , ... The CFOs included on this list ... in the nation and help their organizations navigate the challenges in healthcare today. ... in developing successful hospital and health system strategy. , Becker's Hospital Review has ...
(Date:5/23/2017)... City (PRWEB) , ... May 23, 2017 , ... ... Population Health and Clinical Integration company, announced today that its iClinic V12.2 ... Home (PCMH) 2017 Prevalidation. NCQA recently introduced PCMH 2017 standards which emphasize ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... in North Carolina have remained steady since 2009, according to a Workers Compensation ... , The study Monitoring the North Carolina System: CompScope™ Benchmarks, 17th Edition ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... 2017  May is Stroke Awareness Month and Omron ... important methods to prevent a stroke: monitor and manage ... Control and Prevention, undetected and uncontrolled hypertension is a ... global leader in personal heart health technology, recently evolved ... attack and stroke and is advancing a national public ...
(Date:5/4/2017)... and SAN DIEGO , May ... Gynecologists (ACOG) 2017 Annual Clinical and Scientific Meeting— OBP ... illuminating medical devices, today announced the launch of a ... OfficeSPEC and ER-SPEC vaginal specula. ... of extra-small and extra-large sizes makes OBP Medical,s line ...
(Date:5/3/2017)...  Kalorama Information notes that transplant diagnostics is ... and this is projected to continue to 2021. ... or bone marrow transplants require histocompatibility between the ... this task. This according to a new report ... various PCR-based methodologies, Sanger sequencing and NGS used ...
Breaking Medicine Technology: