Navigation Links
Dendritic cells ensure immune tolerance
Date:3/16/2009

One of the most important tasks of the immune system is to identify what is foreign and what is self. If this distinction fails, then the body's own structures will be attacked, the result of which could be an autoimmune disease such as diabetes mellitus type 1 or multiple sclerosis. The only way to protect against these afflictions is to destroy all immune factors that turn against the body's own tissue in other words: immune tolerance. A team working with LMU researcher Dr. David Vhringer has now investigated exactly what role dendritic cells play in this process. There has long been suspicion that these cells, which are important for the body's defenses, are also essential for the establishment and maintenance of immune tolerance. "We investigated mice that lacked this cell type from birth," reports Vhringer. "It turned out that immune cells that attack the body's own tissue survive in these animals, and thereby trigger an autoimmune response. It follows that dendritic cells play a major part in protecting against autoimmune disease."

T cells are a type of white blood cell that are key actors in the body's immune defenses. Each T cell has a receptor on its surface for recognizing just one single antigen. Antigens are molecular structures, mostly fragments of proteins. T cells do not dock onto free antigens, however: they rely on other cells which can present antigens to them. It is the dendritic cells that are primarily responsible for this job. They present the T cells with various antigens, and if an antigen matches a receptor, then that T cell will trigger an immune response from the body.

This is how the body defends itself against pathogens and other intruders. But behind this tactic lies an element of danger to the organism: what happens if the antigen is not foreign, but originates from the body's own tissue instead? A wrongly induced immune response can lead to a severe autoimmune disease that, if left untreated, could lead to des
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
2. Brain cells work differently than previously thought
3. Embryonic Stem Cells Repair Human Heart
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Circulating fats kill transplanted pancreas cells, study shows
6. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
7. Melanoma drug revs immune cells but cancer cells ignore it
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Embryonic stem cells used to grow cartilage
10. Molecular probe paints cancer cells in living animals, Stanford researchers find
11. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... Sunnyvale, CA (PRWEB) February 27, 2015 ... showcase ClinCapture, its validated Electronic Data Capture (EDC) at ... Francisco, California on March 2nd and March 3rd at ... a self-service platform and DIY CRF and edit-check builder ... Checks in a matter of days, without any programming ...
(Date:2/27/2015)... 2015 Altec Products, Inc., announced today ... ERP Document Management Partner of the Year. ADSS Global ... and other complimentary solutions for their customers across the ... many years to provide clients with paperless solutions that ... “We are thrilled to recognize ADSS Global for their ...
(Date:2/27/2015)... In honor of American Heart Month in February, ... office, is offering tips on how to improve heart health. , ... doesn't mean people have to accept it as their fate. Although ... such as family history, sex or age — there are some ... has six helpful tips to improve heart health and prevent heart ...
(Date:2/27/2015)... 2015 Undocumented farmworkers are half ... use Medicaid, the federal health insurance program available ... new study from UC Davis Health System. The ... farmworker use of Medicaid, which provides coverage for ... status, was having children. , “Undocumented agricultural ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 The federal ... ) that allege use of the statin medication can ... has issued a new order pertaining discovery in the ... Bernstein Liebhard LLP comments. The Order, which was issued ... on February 25th, directs the parties to schedule certain ...
Breaking Medicine News(10 mins):Health News:Clinovo to Demo Its Self-Service, Cloud-Based EDC Solution at CALBIO2015 on March 2nd and 3rd, 2015 2Health News:Altec Announces 2014 Sage ERP Document Management Partner of the Year Award Recipient 2Health News:Center for Primary Care Celebrates American Heart Month 2Health News:Center for Primary Care Celebrates American Heart Month 3Health News:Center for Primary Care Celebrates American Heart Month 4Health News:UC Davis Study Finds Undocumented Farmworkers Use Medicaid Half as Often as Documented Farmworkers 2Health News:UC Davis Study Finds Undocumented Farmworkers Use Medicaid Half as Often as Documented Farmworkers 3Health News:Federal Lipitor Litigation Issues New Order Pertaining to Discovery in Bellwether Cases, Bernstein Liebhard LLP Comments 2Health News:Federal Lipitor Litigation Issues New Order Pertaining to Discovery in Bellwether Cases, Bernstein Liebhard LLP Comments 3
... While the visual regions of the brain have been ... uncharted territory. Now, researchers at the Hebrew University of ... a key auditory process perceiving sound space, the ... concentrating on those sounds. , The findings settle ...
... MEDIA, Pa., Sept. 20 Synova Healthcare Group,Inc. (OTC ... sale,of approximately $3.3 million in aggregate notional principal amount ... September 19, 2012,and related common stock purchase warrants. This ... private placement of notes and warrants in the,aggregate notional ...
... Philadelphia, PA, September 20, 2007 Pedophilia, the sexual ... health concern and it does not respond well to ... not well understood. A new study being published ... the first of its kind to use functional brain ...
... Calif., Sept. 20 Cardiva Medical, Inc.,a privately ... Chairman and CEO, will present at the UBS ... in New York City. Notably, the,company will be ... the,Boomerang Catalyst II System, which recently received a ...
... 19, 2007 -- A single dose of Otsukas ... resulted in favorable changes in hemodynamics associated with ... with advanced heart failure (ADHF) who participated in ... HemodynamIc Parameters in Subjects with HEart failure (ECLIPSE), ...
... Speaker Nancy Pelosi,issued the following statement today on ... a vote of 405 to 7:, "Today,s sweeping, ... all Americans., "Essential to the safety net of ... that the prescription drugs they buy are safe. These ...
Cached Medicine News:Health News:Sensitivity of brain center for 'sound space' defined 2Health News:Synova Completes Sale of $3.3 Million in Senior Convertible Notes and Warrants 2Health News:Synova Completes Sale of $3.3 Million in Senior Convertible Notes and Warrants 3Health News:Pedophilia patients are found to have deficits in brain activation 2Health News:Cardiva Medical, Inc. to Present at the UBS 2007 Global Life Science Conference With the Announcement of FDA 510(K) Clearance of its Newest Device: The Boomerang Catalyst II System(TM) 2Health News:Cardiva Medical, Inc. to Present at the UBS 2007 Global Life Science Conference With the Announcement of FDA 510(K) Clearance of its Newest Device: The Boomerang Catalyst II System(TM) 3Health News:Cardiva Medical, Inc. to Present at the UBS 2007 Global Life Science Conference With the Announcement of FDA 510(K) Clearance of its Newest Device: The Boomerang Catalyst II System(TM) 4Health News:Cardiva Medical, Inc. to Present at the UBS 2007 Global Life Science Conference With the Announcement of FDA 510(K) Clearance of its Newest Device: The Boomerang Catalyst II System(TM) 5Health News:ECLIPSE data on effects of Otsuka's investigational novel treatment, Tolvaptan 2
(Date:2/26/2015)... -- Finesse expands office in Leicester, United Kingdom ... of its operations in Leicester , ... for customers is expected shortly afterward. With ... the current office, the new premises will double the ... Finesse to bring on more service personnel. The new ...
(Date:2/26/2015)...  Today the National Safety Council released ... side effects of pain medications , ... and Oxycontin, are safer options than over-the-counter pain relievers. ... than on heroin and cocaine combined," said Deborah ... these medications are marketed as the Cadillac option for ...
(Date:2/26/2015)... Feb. 26, 2015 Legislation passed today by ... provision to help prevent inappropriate prescriptions in Medicare Part ... the Integrity of Medicare Act (PIMA) of 2014 , ... Kevin Brady (R-TX) and Ranking Member Jim McDermott ... abuse epidemic and implement the right policies, said the ...
Breaking Medicine Technology:New Finesse Office in United Kingdom 2National Safety Council: Opioid prescription painkillers have hidden, deadly side effects 2PCMA Statement on the 'Protecting the Integrity of Medicare Act' 2
... Oct. 5, 2011 Sanofi (EURONEXT: SAN and NYSE: ... today the publication of the pivotal Phase III TEMSO ... The New England Journal of Medicine (NEJM).  Results ... the annual relapse rate, reduced disability progressions and improved ...
... HOUSTON, Oct. 5, 2011 Cyberonics, Inc. (NASDAQ: ... for the treatment and management of epilepsy, today announced ... Inc. ("ImThera").  Based in San Diego, California, ImThera is ... for the treatment of obstructive sleep apnea ("OSA"). ...
Cached Medicine Technology:Investigational Oral Multiple Sclerosis Therapy Teriflunomide (Aubagio™(*)) Significantly Reduced Relapse Rate, Disability Progression and Disease Activity 2Investigational Oral Multiple Sclerosis Therapy Teriflunomide (Aubagio™(*)) Significantly Reduced Relapse Rate, Disability Progression and Disease Activity 3Investigational Oral Multiple Sclerosis Therapy Teriflunomide (Aubagio™(*)) Significantly Reduced Relapse Rate, Disability Progression and Disease Activity 4Investigational Oral Multiple Sclerosis Therapy Teriflunomide (Aubagio™(*)) Significantly Reduced Relapse Rate, Disability Progression and Disease Activity 5Investigational Oral Multiple Sclerosis Therapy Teriflunomide (Aubagio™(*)) Significantly Reduced Relapse Rate, Disability Progression and Disease Activity 6Cyberonics Announces Investment in ImThera Medical 2Cyberonics Announces Investment in ImThera Medical 3Cyberonics Announces Investment in ImThera Medical 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: