Navigation Links
Dendritic cell vaccine for relapsed neuroblastoma patient induces complete remission

One year after his last treatment, a six-year-old boy with recurrent neuroblastoma is in complete remission for his high-risk metastatic cancer. Doctors reported this case study in the January 2013 issue of Pediatrics, the journal of the American Academy of Pediatrics, which was funded in part by a joint grant from the Andrew McDonough B+ Foundation, Pierce Phillips Charity and Solving Kids' Cancer.

Current treatments for high-risk neuroblastoma patients include chemotherapy, radiation therapy, surgery, stem cell transplant, and immunotherapy. Less than half of the children survive in spite of the intensive and toxic standard therapy. Long term survival after a relapse is less than 5%.

Previous clinical trials in adult solid tumors have successfully used cancer-specific targets (NY-ESO-1, MAGE-A1, and MAGE-A3) to kill cancer cells. Now, scientists at the University of Louisville have used these same targets for neuroblastoma by creating a vaccine that causes the body's own immune system to attack the tumor cells. Dendritic cells are immune cells collected from the patient and grown in cultures after they are exposed to specific antigens. The dendritic cells "teach" the patient's T-cells to seek out and kill the cancer cells after they are returned to the patient through a series of injections.

Cancer treatment vaccines differ from other vaccines in that they treat active cancers or help to prevent recurrence. The principal investigator for this study, Kenneth Lucas, M.D., is the division chief of Pediatric Hematology-Oncology and Stem Cell Transplantation at the University of Louisville Department of Pediatrics. The funding provided critical support to further Dr. Lucas' ongoing work to find new treatments for neuroblastoma and other deadly childhood cancers.

In the case study, one year after the patient's last vaccination, the tumors cells that were located in the boy's bone marrow disappeared and he now shows no evidence of disease.

The study includes children with sarcomas as well as neuroblastoma, and will be completed in 2013.

For patients with relapsed neuroblastoma, there are few promising treatment options in clinical trials. More effective and less toxic treatments are desperately needed.

"This research builds on five years of pre-clinical research, which identified three new immunological targets that are specific to this pediatric cancer," said Scott Kennedy, the Executive Director of Solving Kids' Cancer. "The case study highlights the potential therapeutic progress that can be made against neuroblastoma, and brings hope to patients and their families in finding a lasting cure."


Contact: Jenny Song
Solving Kids' Cancer

Related medicine news :

1. After 100 years, understanding the electrical role of dendritic spines
2. SIgN scientists discover dendritic cells key to activating human immune responses
3. The long arm of the dendritic cell
4. Whooping Cough Vaccine for Pregnant Women Among New Recommendations
5. NIH-developed candidate dengue vaccine shows promise in early-stage trial
6. Children with egg allergies can safely receive flu vaccine, U-M study says
7. How Cervical Cancer Vaccines Came to Be
8. Vaccines Might Become Another Way to Fight Cancer
9. FDA Approves New Type of Flu Vaccine
10. Childhood Vaccine Schedule Is Safe, Report Says
11. Spot Shortages of Flu Vaccine, Tamiflu Reported, FDA Head Says
Post Your Comments:
(Date:10/13/2015)... CA (PRWEB) , ... October 13, 2015 , ... ... and workflow solutions, announced today their sponsorship of the Microsoft Dynamics AXUG, GPUG ... Nevada. AXUG Summit, GPUG Summit and NAVUG Summit are independent user conferences designed ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... In an ... utility costs were 36 percent lower per square foot than in 2009. The Williamsport ... cost of heating and cooling has decreased by eight percent. , According to ...
(Date:10/13/2015)... ... October 13, 2015 , ... e-con Systems Inc., a ... announced See3CAM_CU40, the industry’s first RGB-IR pixel format camera with a USB ... member of e-con’s See3CAM family of UVC USB 3.0 cameras, is based on the ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... Anik Singal's newly launched "Publish Academy" training course . Singal's new program, ... for enrollment today, and marketers around the Internet are weighing in with reviews. ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... that targets the unique health needs of new moms. Postnatal Omega-3, which ... ( ), utilizes Nordic Naturals’ exclusive, new, ultra-concentrated omega-3 oil. This ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , Oct. 13, 2015  XiMo AG ( ... Aspira Scientific, Inc. ( Milpitas, California ) ... for metathesis chemistry. The importance of metathesis chemistry was ... the pioneers of this application. This industrially-relevant application has ... such as pharmaceuticals, specialty chemicals, and polymers. ...
(Date:10/12/2015)... , October 13, 2015 the United ... operating in a non-clinical capacity. --> the United ... operating in a non-clinical capacity. --> The University of ... installation of the first high field (1.5 Tesla) MRI-guided linear accelerator ... year, the system will be operating in a non-clinical capacity. ...
(Date:10/12/2015)... , Oct. 12, 2015 ... components such as platelets, RBC, plasma, and other components from ... or a patient is passed through an apheresis machine or ... to separate the required component from other blood components. A ... elements are returned to the donor or the patient. It ...
Breaking Medicine Technology: