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Demonstrated in vivo the transfer of maternal thyroid hormones to the fetus
Date:4/12/2010

hormones can only be of maternal origin, are highlighted in this way those organs and tissues selectively affected by the maternal thyroid hormone". "The action of these hormones is particularly strong in certain brain areas as those from which will originate the thalamus, a structure involved in regulating individual behaviour, and the hypothalamus, in which will develop different regulatory centers of several endocrine-metabolic functions"- yet says the endocrinologist of Catholic University.

But other tissues seem to be affected by thyroid hormone of maternal origin as those which give the inner ear, the eye, the skin and some district of the gastro-intestinal tube.

This transgenic mouse is an important experimental model to study the damaging effects of maternal hypothyroidism and hyperthyroidism during pregnancy and to understand the role of thyroid hormones in regulating metabolism and thermogenic. "Our transgenic mouse may also allows for testing new drugs capable of mimicking some of the actions of thyroid hormones, to be used in the treatment of heart failure, elevated cholesterol levels and in order of slimming claims Prof. Pontecorvi. Furthermore, it can also be used to analyze the effects of various environmental contaminants that can exhibit thyroid-mimetic or anti-thyroid effects, as some sunscreens or substances released from non-stick pans, that have been much talked about recently".


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Contact: Prof. Alfredo Pontecorvi
pontecorvi@rm.unicatt.it
39-333-369-4065
Catholic University of Rome
Source:Eurekalert

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