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Demonstrated in vivo the transfer of maternal thyroid hormones to the fetus
Date:4/12/2010

e lost by each of us at a rate of about 100.000 per day. It is therefore fundamental that the right amount of maternal thyroid hormones is assured during the embryo-fetal development of our neuronal kit".

During the first trimester of pregnancy it is estimated that are maternal thyroid hormones to ensure the fetal thyroid hormone needs, thereby affecting the neuronal development.

"It is known that children of mother with hypothyroidism during pregnancy show a significantly lower QI than the children of mothers with a normal thyroid function - continues Pontecorvi. A similar reduction in QI has been observed in the case of pregnant mothers with a low level of thyroxine, although not exactly hypothyroid, a condition that tends to occur particularly in situation of iodine deficiency. But all these are only indirect evidences in favor of the passage through the placenta of maternal thyroid hormones to the fetus".

What so far was only assumed or inferred has been demonstrated by a recent study, all designed and manufactured in Italy, published in the prestigious Journal of Cellular and Molecular Medicine. The study was conducted by Dr. Carmelo Nucera, currently a researcher at the University of Harvard (USA), and Prof. Alfredo Pontecorvi; have contribuited to it other italian scholars as Prof. Vercelli (Institute of Neuroscience of University of Torino), dr. Tiveron (Fondation EBRI Rita Levi-Montalcini of Rome), dr. Sacchi, dr. Farsetti and dr. Moretti (Institute of Cancers "Regina Elena" and CNR of Rome). Thanks to this multicenter collaboration was created a transgenic mouse model that reveals the presence and the activity of the maternal thyroid hormones very early, before the fetal thyroid function begins.

"The transgenic animal - explains Dr. Nucera - using a molecular sensor that we inserted in the DNA of mouse, develops a characteristic blue color when and where acting thyroid hormones; because early in fetal development thyroid
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Contact: Prof. Alfredo Pontecorvi
pontecorvi@rm.unicatt.it
39-333-369-4065
Catholic University of Rome
Source:Eurekalert

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