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Delivering Chemo Directly Into Brain Tumors Shows Promise
Date:5/4/2009

method of delivering chemotherapy drugs to malignant gliomas, this time using nanoparticles.

After injecting cancerous glioma cells into immunocompromised mice, researchers injected the mice with controlled-release nanoparticles that were able to carry the chemotherapy drug fluorouracil (Adrucil) to the tumor site.

The University of Virginia researchers then used high-intensity ultrasound to release the agents in the microvessels feeding the tumor.

The chemotherapy drug killed the glioma cells in the mice, the scientists reported.

More information

The U.S. National Library of Medicine has more on malignant glioma.



SOURCES: Jeffrey Bruce, M.D., professor, neurological surgery, and co-director, Brain Tumor Center, Columbia University Medical Center, New York City; Paul Fisher, M.D., associate professor, neurology and pediatrics, Stanford Medical Center and the Beirne Family Director of Neuro-Oncology, Palo Alto, Calif.; May 4, 2009, American Association of Neurological Surgeons annual meeting, San Diego


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