Navigation Links
Delivering Chemo Directly Into Brain Tumors Shows Promise
Date:5/4/2009

Survival times for those with malignant gliomas increased, study found

MONDAY, May 4 (HealthDay News) -- Using a catheter to deliver chemotherapy drugs directly into a deadly type of brain tumor is showing promise in early clinical trials, researchers report.

Malignant gliomas are difficult to treat using standard chemotherapy and radiation treatments. Only about 3 percent of patients diagnosed with a malignant glioma survive five years or more, according to background information in the study.

With the new method, researchers inserted catheters carrying the chemotherapy drug Topotecan (Hycamtin) directly into the tumors of 16 patients with recurrent malignant gliomas.

The patients who received the Topotecan had a median survival of 59 weeks, although a few patients lived much longer. The median time to tumor progression was 20 weeks, and 77 percent of patients survived for at least six months.

"Those numbers are better than any treatment for recurrent gliomas we have now," said study author Dr. Jeffrey Bruce, co-director of the Brain Tumor Center at Columbia University Medical Center in New York City.

Findings from the Phase 1 trial are slated to be presented Monday at the American Association of Neurological Surgeons annual meeting, in San Diego.

Malignant gliomas are typically resistant to treatment for several reasons, explained Dr. Paul Fisher, an associate professor of neurology and pediatrics at Stanford Medical Center and the Beirne Family Director of Neuro-Oncology.

Chemotherapy is typically given orally or intravenously. In brain tumors, chemotherapy is not very effective, because drugs are not able to penetrate the blood-brain barrier, which prevents most drugs in the bloodstream from entering the brain, the researchers wrote.

Malignant gliomas also send out tentacles, making the tumors very difficult to completely remove surgically. Even when there's no tumor visible, microscopic glioma cells usually remain that eventually regrow, Fisher said.

Sen. Edward Kennedy (D-Mass.) is currently battling a malignant glioma.

Topotecan is sold by GlaxoSmithKline and is typically used in lung cancer patients, Bruce said.

In the lab, the drug had been shown to be effective in killing malignant glioma cells, but delivering enough of it through the bloodstream to attack brain tumors would cause too many toxic side effects.

So for four days, using a procedure called convection-enhanced delivery, Topotecan was pumped into tumors in 16 patients through two catheters. The pumping was done very slowly, at a rate of several drops an hour, Bruce said.

Side effects included upper extremity weakness and left parietal syndrome, neurological issues caused by damage to the brain.

The patients had two types of tumors: 10 had a glioblastoma multiforme (GBM), an invasive and fast-growing tumor, while six had anaplastic glioma.

"Topotecan by convection-enhanced delivery has significant anti-tumor effects at doses that are not harmful to normal brain tissue," Bruce said. "These promising preliminary results indicate that this treatment provides a survival advantage that is favorable compared to other treatments that are often used for recurrent malignant gliomas."

The next step will be multi-center Phase 2 clinical trial, which will begin in the next two to three months, Bruce said.

Fisher said the results were encouraging, but the study was limited in that it involved only a small number of patients and two different types of tumors.

"The technology is to be applauded," Fisher said. "We need to be trying new approaches and trying to do things in a different way. Just giving chemotherapy by an IV or radiation is not going to advance the field."

A second study that will also be presented at the conference also explored an alternative method of delivering chemotherapy drugs to malignant gliomas, this time using nanoparticles.

After injecting cancerous glioma cells into immunocompromised mice, researchers injected the mice with controlled-release nanoparticles that were able to carry the chemotherapy drug fluorouracil (Adrucil) to the tumor site.

The University of Virginia researchers then used high-intensity ultrasound to release the agents in the microvessels feeding the tumor.

The chemotherapy drug killed the glioma cells in the mice, the scientists reported.

More information

The U.S. National Library of Medicine has more on malignant glioma.



SOURCES: Jeffrey Bruce, M.D., professor, neurological surgery, and co-director, Brain Tumor Center, Columbia University Medical Center, New York City; Paul Fisher, M.D., associate professor, neurology and pediatrics, Stanford Medical Center and the Beirne Family Director of Neuro-Oncology, Palo Alto, Calif.; May 4, 2009, American Association of Neurological Surgeons annual meeting, San Diego


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Leveraging Cloud Computing is the Latest Offering by ICG Consulting to Streamline Costs While Delivering Robust Business Process Solutions
2. ACORNs Success in Delivering Top Quality Research Portfolio to Community-Based Oncology Practices Presented at Annual Investigator Meeting
3. Delivering Bear-y Big Smiles and Millions of Miles
4. SCAN: Delivering Bone Disorder Diagnosis, Fracture Healing
5. SCAN: Delivering bone disorder diagnosis, fracture healing
6. CVS/pharmacy and MinuteClinic Reach Goal of Delivering One Million Flu Vaccinations
7. Creating Brand Advocates by Delivering the Superior Total Customer Experience
8. Historic Lawsuit Challenges Unacceptable Delays in Delivering Benefits to Americas Veterans by Department of Veterans Affairs
9. International Medical Corps Continues Delivering Emergency Relief in Democratic Republic of Congo as Potential for Renewed Fighting Threatens to Deepen Crisis
10. International Medical Corps Continues Delivering Emergency Relief Amid Violence in Democratic Republic of Congo
11. PARI Respiratory Releases Results of Study Comparing Nebulizers Delivering Budesonide at CHEST 2008
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Delivering Chemo Directly Into Brain Tumors Shows Promise
(Date:12/8/2016)... ... 08, 2016 , ... ZyDoc , a New York-based ... Data Capture Methods for Input to Electronic Health Records: A Comparative Usability Study” ... comparative usability study demonstrate that a dictation-based method (“NLP Entry”) using ZyDoc’s MediSapien™ ...
(Date:12/8/2016)... ... December 08, 2016 , ... CURE Media Group, the nation’s leading digital and ... with Upstage Lung Cancer in efforts to combat lung cancer, announced CURE Media Group ... said, “CURE Media Group is honored to team up with Upstage Lung Cancer in ...
(Date:12/8/2016)... ... 2016 , ... Premier Fitness Camp (PFC) and The Chopra Center for Wellbeing ... wellness program, at their world headquarters of Omni La Costa Resort & Spa in ... anyone seeking weight loss, personal development, a healthy lifestyle, or mental and physical healing. ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... development solutions for drugs, biologics and consumer health products, today announced that it ... up in 2006 as a non-profit organization to unite pharmaceutical and healthcare companies ...
(Date:12/8/2016)... ... ... California Senate Bill (SB) 863, signed into law in 2012, may have ... according to CompScope™ Medical Benchmarks for California, 17th Edition , a study by ... payments per claim in California decreased 4 percent in 2013 and then 3 percent ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016 True Health ... brings leading-edge laboratory services and management expertise to ... , allowing more doctors and patients to ... management solutions. Logo - http://photos.prnewswire.com/prnh/20161208/447162LOGO ... Hospital systems, under pressure to contain costs, have ...
(Date:12/8/2016)... Research and Markets has announced the addition of the ... ... The global chromatography market to grow at a CAGR of 5.42% during ... prepared based on an in-depth market analysis with inputs from industry experts. ... coming years. The report also includes a discussion of the key vendors ...
(Date:12/8/2016)... , December 8, 2016 ... "Sugar-Based Excipients Market by Product (Actual Sugars, Sugar ... (Filler & Diluent, Tonicity Agents), Formulation (Oral, Topical, ... MarketsandMarkets, the market has witnessed healthy growth during ... at a CAGR of 4.3% between 2016 and ...
Breaking Medicine Technology: