Navigation Links
Delay in surgery not likely to worsen tumors in men with low-risk prostate cancer
Date:6/8/2010

Johns Hopkins experts have found that men enrolled in an active surveillance program for prostate cancer that eventually needed surgery to remove their prostates fared just as well as men who opted to remove the gland immediately, except if a follow-up biopsy during surveillance showed high-grade cancer.

Active surveillance, or "watchful waiting," is an option open to men whose tumors are considered small, low-grade and at low risk of being lethal. Given the potential complications of prostate surgery and likelihood that certain low-risk tumors do not require treatment, some men opt to enroll in active surveillance programs to monitor PSA levels and receive annual biopsies to detect cellular changes that signal a higher grade, more aggressive cancer for which treatment is recommended. Yet, according to the Johns Hopkins experts, there is concern that delaying surgery in this group until biopsy results worsen may result in cancers that are more lethal and difficult to cure.

Bruce Trock, Ph.D., associate professor at the Johns Hopkins Brady Urological Institute, and his colleagues compared the pathology results of men in an active surveillance group at Johns Hopkins who later had surgery with those who also had low-risk tumors and opted for immediate surgery.

Results initially showed that 116 active surveillance participants who had surgery were more likely to have high-grade, larger tumors than 348 men who had immediate surgery. But Trock says that these results were found only in 43 (37 percent) men in the surveillance group who were recommended for surgery because a follow-up biopsy during surveillance worsened to indicate a high-grade tumor.

"We think that these men had high-grade tumors to begin with that their initial biopsy missed, and this group may be over-represented in men who are recommended for treatment after an initial period of active surveillance," says Trock. He adds that, in general, 15 to 25 percent of men whose initial biopsy shows a low-risk prostate tumor will actually have a high-grade cancer upon further review of the entire prostate once it is removed.

Apart from the 43 men whose pathology results worsened during surveillance, the remaining men in the surveillance group had similar pathology results at surgery to those in the immediate surgery group. "This means that most tumors are not likely to worsen during the period of active surveillance," says Trock.

The researchers calculate that the risk of finding high-grade tumors in the entire group of 801 active surveillance patients is low -- about 4.5 percent per year.


'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. No Benefit Seen in Delaying Infant Vaccinations
2. $18.5 Million New Jersey Medical Malpractice Birth Injury Verdict Due To Cerebral Palsy Caused By A Delayed C-Section
3. Lower wages, lack of job opportunities means more Americans delaying adulthood
4. Brain Area That May Delay Need for Gratification Found
5. Money Worries Delay Heart Attack Treatment
6. Targeting the blood-brain barrier may delay progression of Alzheimers disease
7. Delayed retirement among Americans may bolster future of Social Security and Medicare, study finds
8. In brain-injured children, early gesturing predicts language delays
9. Pain Relief Often Delayed for Cancer Patients
10. Green Tea Extract May Delay or Prevent Alzheimers
11. Delaying post-surgical radiation increases risk of breast cancer recurrence in older women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... ... February 28, 2017 , ... ... in North America for the scientific development, healthcare training and clinical application of ... & Scientific Session on September 16-17 in Greenville, SC at the Bon Secours ...
(Date:2/28/2017)... (PRWEB) , ... February 28, 2017 , ... Las Vegas ... revamped South Rancho location on Friday, March 10, 2017, 4-7 pm PST. For more ... but this clinic, located in the South Rancho neighborhood, has been renovated to provide ...
(Date:2/28/2017)... (PRWEB) , ... February 28, 2017 , ... BrightStar Care ... of Choice Awards from Home Care Pulse. This award is granted only to top-ranking ... BrightStar Care Marietta is now ranked among home care providers from across the ...
(Date:2/27/2017)... ... 2017 , ... Bo Chen, PhD is the recipient of the 2017 ASLMS ... the Plenary Session at ASLMS 2017, the Annual Conference of the American Society for ... 5-9, 2017. , During the Plenary Session on April 7, Dr. Chen will ...
(Date:2/27/2017)... , ... February 27, 2017 , ... Robert E. Burke, ... medical group. But his impoverished upbringing and life experiences could have led him down ... Physician: Insightful and Inspirational Tales of Parenting, Perseverance and Pediatrics,” Dr. Burke shares a ...
Breaking Medicine News(10 mins):
(Date:2/28/2017)... ... and Markets has announced the addition of the "Active Pharmaceutical ... The global active pharmaceutical ingredients (API) market is ... The rising prevalence of lifestyle-induced & age-related diseases and cancer is ... recombinant molecular technologies and high capitalization for development of novel drugs ...
(Date:2/28/2017)... SINGAPORE and SAN FRANCISCO , February 27, 2017 ... four Se D ... portfolio of biotechnology assets   LOI contemplates capital ... term growth plan for building shareholder value   Amarantus names ... interim-CFO of Amarantus   SeD Biomedical Inc. ...
(Date:2/28/2017)... February 28, 2017 The global  pulse oximeters market  is ... by Grand View Research, Inc. The pulse oximeters market is anticipated to witness ... prevalence of target diseases such as chronic obstructive pulmonary disease (COPD), sleep apnea, ... ... Grand View Research Logo ...
Breaking Medicine Technology: