Navigation Links
Degenerative cervical spine disease may not progress over time
Date:2/19/2013

Philadelphia, Pa. (February 19, 2013) - Follow-up data on patients with degenerative disease of the upper (cervical) spinal vertebrae show little or no evidence of worsening degeneration over time, according to a study in the February 15 issue of Spine. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

For many patients with "unstable" cervical degenerative spondylolisthesis, observation may be a better choice than surgery, according to the new research by Dr Moon Soo Park and colleagues of Medical College of Hallym University, Republic of Korea. They write, "Our results suggest that the majority of these patients may be stable and do not develop progression of disease or catastrophic neurologic deficits."

Is Unstable Spondylolisthesis Really Unstable?

The researchers analyzed the "natural history" of cervical degenerative spondylolisthesis in 27 patients. Degenerative spondylolisthesis refers to "slipped" vertebrae caused by bone degeneration. Because spondylolisthesis is commonly thought to result in instability of the cervical spine, spinal fusion surgery (arthrodesis) is sometimes considered the appropriate treatment.

The 16 men and 11 women in the study underwent cervical spine radiographs (x-rays) on two occasions at least two years apart. The patients' average age at the time of the initial radiograph was 59 years; average time to the follow-up radiographs was 39 months. Measurements on the paired radiographs were carefully compared to determine whether and how much the cervical slippage increased over time.

Initial x-rays showed "instability"at least two millimeters of displacement between vertebraein several patients. However, during follow-up, none of the patients had further progression, defined as additional displacement of two millimeters or more. The average progression was only about one-half millimeter.

Twenty-one patients had backward displacement ("retrolisthesis") of the cervical vertebrae, while six had forward displacement ("anterolisthesis"). The patients with retrolisthesis had somewhat greater slippage during follow-up; however, none had a dislocation or suffered neurological damage.

No Progression of 'Slippage' or Symptoms

Of 16 patients who had symptoms such as neck pain or sensory abnormalities at the initial visit, most were successfully managed without surgery. Of the 11 patients who were initially symptom-free, none developed symptoms during follow-up.

The study is one of the few to look at the "natural history" of cervical spondylolisthesis. The results suggest that, at medium-term follow-up, the conditions appears to be "relatively stable" in most patients. Dr Park and colleagues write, "This begs the question, if an 'unstable' listhesis does fine without treatment, is it really unstable? Our results suggest that the majority of these patients may be stable and do not develop progression of disease or catastrophic neurologic deficits."

The researchers acknowledge some important limitations of their studyparticularly the small number of patients and relatively short follow-up. However, the results suggest that, for many patients, cervical spondylolisthesis is a non-progressive condition that does not necessarily require surgical treatment. Dr Park and coauthors conclude, "In the absence of neurologic symptoms, we recommend observation of patients with degenerative spondylolistheses of the cervical spine."


'/>"/>

Contact: Connie Hughes
connie.hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

Related medicine news :

1. New understanding can lead to srategies for dealing with neurodegenerative diseases
2. Researchers find chemical switches for neurodegenerative diseases
3. LA BioMeds Dr. Patricia Dickson researching treatments for neurodegenerative disorders
4. Bascom Palmer Eye Institute announces breakthrough for degenerative vision disorder
5. Avastin May Help Boost Survival With Aggressive Cervical Cancer: Study
6. Cunningham Financial Group Encourages Women to Celebrate “Cervical Health Awareness Month” by Following Important Health Tips
7. Cervical Health Awareness Month 2013: Maternal & Family Health Services Focuses on Access to Reproductive Healthcare to Reduce Cervical Cancer
8. How Cervical Cancer Vaccines Came to Be
9. Research makes connetion between tubal ligation and increase in cervical cancer rates
10. Cervical cancer screening in less-developed areas should be tailored to local conditions
11. New test may improve cervical cancer detection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... ... therapy products, announced today the introduction of the newly designed, innovative shoulder wrap. ... and better cold therapy coverage for the injured arm and shoulder to promote ...
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... i2i Systems, ... of the highest preliminary data vendors in the latest KLAS report, Population Health Management ... has led the developing market for population health management (PHM). The latest KLAS ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Federal Laboratory ... federallabs.org . The site houses a wealth of federal resources that businesses can ... process called technology transfer (T2). As a network of over 300 federal laboratories, ...
(Date:2/8/2016)... , ... February 08, 2016 , ... The Valentine’s Season is famous for gift giving ... significant others that they are loved. This year, for more than 5.6 million Americans ... - just won't be enough to remind them of the lives they’ve led and the ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... and clothing, announced expansion into Canada to provide its range of unique and ... sales office in Quebec City that will provide bilingual customer service and marketing ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... 2016  The Parenteral Drug Association, Inc. (PDA), ... manufacturing sterile drug products, today announced the publication ... – With link to Comparison Spreadsheet. The ... U.S. FDA, the EU, the Pharmaceutical Inspection Convention/Scheme ... --> --> PDA,s Global Sterile ...
(Date:2/8/2016)... LONDON , Feb.8, 2016 Cardiovascular ... Summary GlobalData,s Medical Devices sector report, ... 2015" provides an overview of Cardiovascular Surgery Devices ... --> The report provides comprehensive ... of the products at various stages of development. ...
(Date:2/8/2016)... and FAIRFIELD, N.J. , Feb. 8, ... Pharmaceuticals, Inc. (Medimetriks) today announced that they have entered ... commercialization rights for OPA-15406 in the U.S. and ... manufacturing rights.  OPA-15406 is a topical, non-steroidal phosphodiesterase IV ... --> --> In ...
Breaking Medicine Technology: