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Deficiency in p53 anti-tumor protein delays DNA repair after radiation, Moffitt researchers say
Date:4/22/2013

function of p53 may be particularly important in higher organisms because of the increased complexity of their genomes."

Although they note that there is no general consensus on the relationship between p53 mutation status and treatment response, in certain narrow settings such as breast cancer, p53 mutation is associated with favorable response to chemotherapy.

"We can conclude that the chromatin modifiers SUV39H1 and JMJD2b are important mediators of p53 function in maintaining the stability of highly repetitive DNA sequences, and developing new drugs that target these enzymes may benefit cancer therapy," the researchers wrote.


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Contact: Kim Polacek
kim.polacek@moffitt.org
813-504-9706
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

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