Navigation Links
Defective signaling pathway sheds light on cystic fibrosis
Date:2/14/2010

In a study that could lead to new therapeutic targets for patients with the cystic fibrosis, a research team from the University of California, San Diego School of Medicine has identified a defective signaling pathway that contributes to disease severity. In the study, published in the journal Nature Medicine, the researchers report that defective signaling for a protein called the peroxisome proliferator-activated receptor-γ (PPAR-γ) accounts for a portion of disease symptoms in cystic fibrosis, and that correction of the defective pathway reduces symptoms of the disease in mice.

In the paper published in the February 14 edition of the journal, lead investigator Gregory Harmon, MD, study supervisor Christopher Glass, MD, PhD, professor of cellular and molecular medicine, and colleagues show that both mice and cells from patients with cystic fibrosis have a defect in signaling for PPAR-γ, as a result of reduced levels of prostaglandins that activate the receptor.

Cystic fibrosis is the most common, potentially lethal genetic disease among whites, occurring in one in 3,000 births. The disease is a multisystem condition that leads to progressive lung failure, pancreatic failure and gastrointestinal obstruction, or blockage.

"Cystic fibrosis results from a genetic mutation in a channel, or membrane pore, that facilitates the transport of chloride and bicarbonate electrolytes from inside the cell to the spaces outside the cell," said Harmon. "Loss of the cystic fibrosis pore channel results in inflammation and mucus accumulation. It also results in dehydration of the cell surfaces that make up the lining spaces inside the lungs and other affected organs, such as the intestinal tract."

Exactly how the process occurs has been a matter of intense scientific scrutiny; yet despite numerous therapeutic advances, individuals with the disease continue to endure a shortened lifespan. "Someone born in the 1990s wit
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Quality control mechanism tags defective sperm cells inside the body
2. Defective Chinese Drywall Lawsuit: Florida Homeowners' Associations and Condominium Associations Plagued by Defective Chinese Drywall Urged to Investigate their Rights
3. Class Action Filed Against South Florida Developer and Supplier of Defective Chinese Drywall
4. Consumer Group Releases New Study About Defective Heart Devices and Implants; Patients Arrive in DC Tomorrow
5. Emory researchers identify signaling protein for multiple myeloma
6. Cooper Clinic at Craig Ranch Opens Signaling the Next Phase of CooperLife Health-Focused Residential Community in McKinney
7. Scientists shed light on long-distance signaling in developing neurons
8. St. Jude finds signaling system that halts the growth of a childhood brain cancer
9. Signaling protein helps limit damage in heart attack, Jefferson scientists show
10. Model offers new understanding of cell signaling
11. Researchers learn how signaling molecule orchestrates breast cancers spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... August 30, 2014 “In 2013, a vehicle ... Jones Firm says in a recently released article on ... was injured in an auto accident every 12 minutes, and ... they continue. “Based on the 2013 statistics, between now and ... collision.” , The threat of an auto accident is real ...
(Date:8/30/2014)... MA (PRWEB) August 30, 2014 Barton ... nurse practitioner locum tenens company , announces a ... September 1, 2014. Barton Associates is headquartered in Peabody, ... CT; Keene, NH; and Jupiter, FL. , ... to the increasing demand for healthcare providers. The United ...
(Date:8/30/2014)... 2014: The first multidisciplinary recommendations on the management ... (ACS) are published today in EP Europace ... by the European Heart Rhythm Association (EHRA), the ... Association of Percutaneous Cardiovascular Interventions (EAPCI), all of ... chairperson of the task force, said: "Sudden cardiac ...
(Date:8/30/2014)... Saturday 30 August 2014: The therapeutic benefit ... emphasised in the 2014 ESC/EACTS revascularisation guidelines presented ... Professor Stephan Windecker (Switzerland) of the European Society ... of the European Association for Cardio-Thoracic Surgery (EACTS). ... European Heart Journal (1), on the ...
(Date:8/29/2014)... (PRWEB) August 30, 2014 AGH Healthy ... the Doctors in Delaware at Atlantic General ... free health-related services. In addition to no-cost blood pressure ... offers first aid care at local sports tournaments. ... other medical staff provide free disease management and falls ...
Breaking Medicine News(10 mins):Health News:Startling Washington Auto Accident Statistics Discussed In Recently Released Article By The Jones Firm 2Health News:Barton Associates Announces New Office Location in Austin, TX 2Health News:First multidisciplinary recommendations on management of arrhythmias in ACS patients 2Health News:ESC/EACTS revascularization guidelines stress benefit of revascularization in stable CAD 2Health News:ESC/EACTS revascularization guidelines stress benefit of revascularization in stable CAD 3Health News:Doctors in Delaware from Atlantic General Hospital Offer No-Cost Services to Area Residents 2Health News:Doctors in Delaware from Atlantic General Hospital Offer No-Cost Services to Area Residents 3
... The pharmaceutical industry is a "market for lemons," a ... buyer about the product and can profit from selling products ... believe, according to an analysis that will be presented at ... "Sometimes drug companies hide or downplay information about serious side ...
... study shows the impact of alcohol intoxication on reasoning ... feel they have recovered enough to drive after drinking. ... president of research for Lifespan, is the first to ... rising and declining blood alcohol concentrations, at matched blood ...
... , TUESDAY, Aug. 17 (HealthDay News) -- Nearly 40 percent ... episodes of manic behavior, a new study suggests. Researchers ... that these patients have what,s called "subthreshold hypomania" -- meaning ... days, and is therefore below the threshold for bipolar disorder. ...
... Community Living Assistance Services and Supports (CLASS) Act a ... Care Act has the potential to transform long-term care ... insurance-based system, according to the latest issue of ... With funding from The SCAN Foundation , this ...
... for airway repair in the lung but that persist in ... poor prognosis in patients who develop cancer, even those with ... have found. These adult stem cells are found in ... areas, suggesting that these cells may mutate and become cancer ...
... an Aging America" will be the focus of the 24th ... Aging from 8 a.m. to 3:30 p.m. Wednesday, Sept. 8 ... The conference, sponsored by The University of Texas Health ... Aging, will include panel discussions, a keynote address by Robert ...
Cached Medicine News:Health News:Pharmaceuticals: A market for producing 'lemons' and serious harm 2Health News:Pharmaceuticals: A market for producing 'lemons' and serious harm 3Health News:Why drunk drivers may get behind the wheel 2Health News:Why drunk drivers may get behind the wheel 3Health News:Many Depressed People Have Mild, Brief Episodes of Mania 2Health News:CLASS Act analysis reveals America's long-term care future 2Health News:Lung stem cells vital to lung repair associated with poor cancer prognosis when found in tumor 2
(Date:8/29/2014)... Research and Markets has announced ... Forecast of Pharmaceutical Equipment Market in China, 2014-2018" ... Development Trend Forecast of Pharmaceutical Equipment Market in ... China,s pharmaceutical equipment industry in the aspects ... and business performance of domestic major enterprises, as well ...
(Date:8/29/2014)... 2014 According to the ... Services (Equipment, Reagent, Primer, Probe, Custom Oligos), End-User ... Gene Synthesis, NGS, DNA, RNAi) - Global Forecast ... Synthesis Market is expected to reach $1,712.1 Million ... at a CAGR of 9.8% from 2014 to ...
(Date:8/29/2014)... 2014 /PRNewswire-iReach/ -- ChemImage will present a workshop focused ... Zealand Forensic Science Society,s 22 nd International ... Adelaide, Australia .  Forensic Scientists will be ... hyperspectral imaging can bring to examination procedures. ... of Product Development at ChemImage, will host a ...
Breaking Medicine Technology:Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3
... The Professional Gold Package is ... laboratory. The package includes the ... automated system, starter package accessory ... adapter, specimen mounts 1/2" head, ...
... Semi-Automatic Tissue Sectioning System has maintained the ... system. Researchers from around the globe have ... their fresh and fresh fixed tissue sectioning ... With the Vibratome Automatic Tissue Sectioning Systems, ...
... Plus Sectioning System provides a versatile means ... plant tissues. The 1000 employs a ... freezing or embedding. The creation of ... of enzyme activities, and other deleterious effects ...
... with a square vice mounting device. ... for mounting specimens and placing in ... blocks are annodized black for easy ... They are shipped three to ...
Medicine Products: