Navigation Links
Deep-space travel could create heart woes for astronauts
Date:4/7/2011

Astronauts anticipate more trips to the moon and manned missions to Mars. But exposure to cosmic radiation outside the Earth's magnetic field could be detrimental to their arteries, according to a study by University of Alabama at Birmingham researchers published April 6, 2011, online in the journal Radiation Research.

Using an animal model, researchers assessed the affect of iron ion radiation commonly found in outer space to see if exposures promoted the development of atherosclerosis, as terrestrial sources of radiation are known to do. They observed that cosmic radiation accelerated the development of atherosclerosis, independent of the cholesterol levels or circulating white blood cells of the mice. It also worsened existing atherosclerotic lesions.

"It's well known that prolonged exposure to radiation sources here on Earth, including those used in cancer treatment, excessive occupational exposure and atomic bombs, are associated with an increased risk for atherosclerosis," said Dennis Kucik, M.D., Ph.D., associate professor in the UAB Department of Pathology. "But cosmic radiation is very different from X-rays and other radiation found on Earth. The radiation risks of deep-space travel are difficult to predict, largely because so few people have been exposed."

Accelerated ions in cosmic radiation interact differently with objects and people, Kucik said.

X-rays can be blocked by lead shields; however, cosmic radiation ions can become more dangerous when they interact with metals, generating secondary particles that also may have biological effects. Although it is possible to use other materials to shield against ion radiation, incorporating these into spacesuits presents significant challenges.

The only people who have been exposed to high levels of cosmic radiation are the 24 astronauts who have been to the moon as part of NASA's Apollo missions in the late 1960s and early 1970s. Kucik said because many people have early atherosclerosis -- whether they travel in space or not they could not draw any conclusions from the small number of astronauts who have been outside the Earth's magnetic field. And, he added, even if they could, with so few people it would be impossible to perform a relevant epidemiological study

Instead, Kucik and his colleagues examined atherosclerosis development in mice following targeted exposure to a particle beam of high-velocity iron ions similar to those found in space produced by scientists at Brookhaven National Laboratory in New York. They analyzed the mice at 13 and 40 weeks afterward to assess the development of atherosclerosis in the aorta and carotid arteries. They concluded there was involvement of components in the arterial wall in the biological response to radiation injury.

"At 13 weeks it was surprising and quite remarkable that we already could see permanent damage an irreversible thickening of the artery wall where it had been exposed to radiation," said co-author Janusz Kabarowski, Ph.D., assistant professor in the UAB Department of Microbiology. "The irradiation had no significant effect on the frequency of circulating immune and inflammatory white blood cells or plasma lipid profile."

Knowing the effects of cosmic radiation on the heart health of deep-space astronauts will help meet the unique challenges of treatment and prevention posed by missions of long duration, Kabarowski said. "Our future research will look at the mechanisms causing the damage, and we will try to find a way to target those mechanisms to correct the damage or prevent it altogether."

Kucik said the team's findings also may inform cancer treatment. Newer proton radiation therapies can be targeted to stop and deposit all of their energy in a tumor, much like iron ions from space stop in the body. "No one knows the atherosclerotic risk of this therapy," Kucik said. "Anything we learn through these studies on deep-space travel will be useful for cancer patients."


'/>"/>

Contact: Jennifer Lollar
jpark@uab.edu
205-934-3888
University of Alabama at Birmingham
Source:Eurekalert

Related medicine news :

1. Jion Beijing Great Wall International Travel Agency Immediate Exposure to China Expo 2010
2. UQ research shows canecutters disease on the rise among travelers
3. 57 Year-Old Grandmother Travels to Atacama Desert to Run First of Four Ultramarathons for Charity
4. Travel to 10 Best Eco-Adventure Destinations in India with Thrillophilia
5. HealthTraveler™ is World's First Mobile App for Medical Tourism
6. Abington Memorial Hospital's Travelers Clinic Can Protect Travelers From The Now Active Yellow Fever
7. Just in Time for Spring Break 2010, AssistCard Mexico Launches Concierge-style Health and Security Services for Travelers to Mexico
8. Just in Time for Spring Break 2010, AssistCare Mexico Launches Concierge-style Health and Security Services for Travelers to Mexico
9. Genealogical tourism redefining leisure travel market, professor says
10. Air Travel Could Raise Risk for Heartbeat Irregularities
11. Spring Break Travel Begins with iTriage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine ... Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dublin - ... " Global Markets for Spectroscopy Equipment" report ... This report focuses on the global market of ... applications in various applications. The report deals with spectroscopy ... industries: pharmaceutical and biotechnology, food and beverage, and environmental ...
(Date:6/24/2016)... Mass. and SAN CLEMENTE, Calif. , ... California -based mobile pulmonary function testing company, is now able ... PFT devices developed by ndd Medical Technologies , Inc. ... testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® ... , can get any needed testing done in the comfort ...
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
Breaking Medicine Technology: