Navigation Links
Deep genomic analysis identifies a micro RNA opponent for ovarian cancer
Date:2/11/2013

.

Starting with 2,942 genes that TCGA identified as overexpressed in the mesenchymal group, they narrowed that list to 253 genes, 219 of which were associated with miRNA.

They found that the 219 miRNA-associated mesenchymal genes divided 455 ovarian cancer patients into two clusters:

  • 171 with high levels of miRNA expression, 169 of whom had high-grade disease, and shorter survival, classified as the mesenchymal subtype.
  • 284 with low levels of miRNA gene expression, longer survival and lower grade disease, classified as the epithelial subtype.

The team confirmed these results in three independent data sets totaling 560 ovarian cancer patients.

Nineteen miRNAs were identified, eight of which were predicted to control 89 percent of the 219 miRNA-associated genes. Of the eight, the least was known about miR-506, and it was least expressed in the mesencyhmal cases. "We decided to focus on miR-506," Zhang said.

miR-506 blocks mesenchymal, helps epithelial proteins

In a series of cell line experiments, the scientists forced overexpression of miR-506 and a control miRNA in ovarian cancer cells. Treated cells had much lower levels of two important mesenchymal markers and higher levels of E-cadherin, a protein vital to epithelial cells.

Additional experiments showed miR-506 specifically inhibited SNAI2, a mesenchymal-cell-promoting protein, by binding to the promoter region of its gene, blocking activation.

Transforming growth factor beta (TGF) induces epithelial-to-mesenchymal cell transition, and the team found that it was prominent in the mesenchymal type of ovarian cancer. In cancer cells treated with miR-506 and then treated with TGF, the miRNA completely abolished TGF's effects.

In human tumors, more miR-506 tied to improved survival

Analysis of 92 ovarian cancer tumors from Tianjin Hospital in Tianjin, China, showed:

  • Tumors with low leve
    '/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Nurses at forefront of genomics in health care
2. Genomic sequencing identifies mutant drivers of common brain tumor
3. Epigenomic abnormalities predict patient survival in non-Hodgkins lymphoma
4. When will genomic research translate into clinical care -- and at what cost?
5. NIH grant moves pathologists to the forefront of genomic medicine
6. Stanford/Yale study gives insight into subtle genomic differences among our own cells
7. Study shows large-scale genomic testing feasible, impacts therapy
8. Ontario Genomics Institute invests in stem cell technology at Tissue Regenerative Therapeutics
9. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
10. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
11. $8.9 million NIH grant to study genomic link to premature heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Deep genomic analysis identifies a micro RNA opponent for ovarian cancer
(Date:10/22/2014)... (PRWEB) October 22, 2014 Best Cheap ... in the world. The site has recently announced that ... hosting supplier for people from around the world. , ... in operation today and is providing various kinds of ... the company insists on offering excellent customer service and ...
(Date:10/22/2014)... 2014 Although there are only 24 hours in ... people who have trouble finding time within their busy schedules for ... long periods of time to get in shape. Here are five ... the go. , Change Up Your Commute , Consider riding ... add some exercise into your daily routine. If you must use ...
(Date:10/22/2014)... MA (PRWEB) October 22, 2014 ... new solutions for the treatment of bacterial infections, microbial ... Sinskey has joined its board of directors. , ... and Engineering Systems at The Massachusetts Institute of Technology, ... MIT faculty since 1968. Dr. Sinskey also holds positions ...
(Date:10/22/2014)... (HealthDay News) -- Two sisters in high school have ... Ilina and Medha Krishen use electronic stethoscopes, which electronically ... in breathing patterns or heartbeats. Ilina, a senior ... to find a way to detect early lung damage ... electronic stethoscope, Ilina recorded one breath cycle each from ...
(Date:10/22/2014)... Oct. 21, 2014 (HealthDay News) -- Measures taken by ... in Ebola-ravaged Liberia may have limited the spread of ... report. The Firestone Natural Rubber Co. provides health ... residents of nearby densely populated communities. Between Aug. ... suspected Ebola cases among those 80,000 people. That incidence ...
Breaking Medicine News(10 mins):Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Akeso Biomedical Appoints Dr. Anthony J. Sinskey to Board of Directors 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2
... are less prevalent than thought. However, when they do ... characteristics measured as early as five months, according to a ... SLEEP. , The study, led by Valrie Simard, under the ... sampled 987 children in the Province of Quebec, who were ...
... Forest University Baptist Medical Center suggests that a three-drug ... glioblastoma multiforme (GBM), a type of brain tumor with ... been developed, and the team is working on the ... cells and spare healthy brain., Waldemar Debinski, M.D., Ph.D., ...
... ... Boards Merge, CANTON, Ohio, Dec. 31 Two county boards have,merged ... Alcohol and Drug Addiction Services Board of Stark County are,now a single ... "The combined Board will create a stronger advocate for people with,mental ...
... YORK, Dec. 31 The holidays are here, which ... drinks like gingerbread,cookies and egg nog! But overindulging in ... on the pounds, it can also take a toll ... from Pharmavite at:, http://media.medialink.com/WebNR.aspx?story=34272 , Registered journalists can ...
... 31 SPX Corporation,(NYSE: SPW ) today ... a,global manufacturer of process equipment and engineered solutions ... APV greatly enhances our process equipment,operations serving key ... Pacific," said Chris Kearney, Chairman, President and CEO ...
... May Be Cost-Effective Method of Screening for Breast Cancer, but ... A cost-effectiveness study of the value of digital mammography breast ... result in sufficient health gains to warrant its increased cost ... women with dense breasts (Article, p. 1). , The study ...
Cached Medicine News:Health News:Preschoolers' nightmares less prevalent, are trait-like and associated with personality 2Health News:Preschoolers' nightmares less prevalent, are trait-like and associated with personality 3Health News:Research suggests new treatment suitable for all patients 2Health News:Research suggests new treatment suitable for all patients 3Health News:Combined Boards Provide Better Care to More Clients More Efficiently 2Health News:SPX Corporation Completes Acquisition of APV 2Health News:Annals of Internal Medicine tip sheet for Jan. 1, 2008, issue 2
(Date:10/20/2014)... Colo. , Oct. 20, 2014  Luoxis ... (NYSE MKT: AMPE), today announced that its academic ... clinical and research potential for its novel RedoxSYS ... potential (ORP) in the body in response to ... value of ORP as a clinical marker will ...
(Date:10/20/2014)... 2014 Valeritas, Inc., a leader in simple, ... Type 2 diabetes, announced today that it has received ... award was presented October 16 th at Cardinal,s ... . The Cardinal Health Supply ... of metrics specifically targeted at the importance of developing ...
(Date:10/20/2014)... , Oct. 20, 2014  AnaptysBio, Inc., a ... antibodies, today announced the appointment of Marco ... Londei will lead the preclinical and clinical development ... "We are pleased to welcome Dr. Londei to ... , President and Chief Executive Officer of AnaptysBio. ...
Breaking Medicine Technology:Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 2Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 3Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 4Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 5Valeritas Receives 2014 Cardinal Health Supply Chain Excellence Award 2Valeritas Receives 2014 Cardinal Health Supply Chain Excellence Award 3AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2
... Oct. 28, 2011 Watson Pharmaceuticals, Inc. (NYSE: ... Paul Bisaro, Watson,s President and Chief Executive Officer, will provide ... 2011 Annual Credit Suisse Health Care Conference on Wednesday, November ... the Arizona Biltmore Hotel in Phoenix. The presentation will be ...
... Pharma, LLC. is pleased to announce today the presentation ... and completed analysis of a Phase I study of ... stabilized analogue of endomorphin 1, a naturally occurring pain ... in normal healthy volunteers with additional pharmacodynamic end points.  ...
Cached Medicine Technology:
... patients with a diseased heart, the only therapy solution ... transplant. However, donor organs are not always readily available. ... are on the waiting list for a donor organ. ... save the life of a patient. On the one ...
The SonoSite MicroMaxx gives you big machine performance in a lightweight package. This laptop-sized, durable unit represents the technology crossover point between hand-carried ultrasound and larger...
... The Nichols Advantage® 25-Hydroxyvitamin D Assay is ... Specialty System. The Nichols Advantage® 25-Hydroxyvitamin D ... of 25-,hydroxyvitamin D (25-OH-D) and other hydroxylated ... plasma to be used as an aid ...
... The CoaguChek Pro is a ... of the coagulation parameters PT, APTT, ... professional use in hospitals and medical ... e.g., in cardiac catheterization laboratories, and ...
Medicine Products: