Navigation Links
Deep genomic analysis identifies a micro RNA opponent for ovarian cancer
Date:2/11/2013

.

Starting with 2,942 genes that TCGA identified as overexpressed in the mesenchymal group, they narrowed that list to 253 genes, 219 of which were associated with miRNA.

They found that the 219 miRNA-associated mesenchymal genes divided 455 ovarian cancer patients into two clusters:

  • 171 with high levels of miRNA expression, 169 of whom had high-grade disease, and shorter survival, classified as the mesenchymal subtype.
  • 284 with low levels of miRNA gene expression, longer survival and lower grade disease, classified as the epithelial subtype.

The team confirmed these results in three independent data sets totaling 560 ovarian cancer patients.

Nineteen miRNAs were identified, eight of which were predicted to control 89 percent of the 219 miRNA-associated genes. Of the eight, the least was known about miR-506, and it was least expressed in the mesencyhmal cases. "We decided to focus on miR-506," Zhang said.

miR-506 blocks mesenchymal, helps epithelial proteins

In a series of cell line experiments, the scientists forced overexpression of miR-506 and a control miRNA in ovarian cancer cells. Treated cells had much lower levels of two important mesenchymal markers and higher levels of E-cadherin, a protein vital to epithelial cells.

Additional experiments showed miR-506 specifically inhibited SNAI2, a mesenchymal-cell-promoting protein, by binding to the promoter region of its gene, blocking activation.

Transforming growth factor beta (TGF) induces epithelial-to-mesenchymal cell transition, and the team found that it was prominent in the mesenchymal type of ovarian cancer. In cancer cells treated with miR-506 and then treated with TGF, the miRNA completely abolished TGF's effects.

In human tumors, more miR-506 tied to improved survival

Analysis of 92 ovarian cancer tumors from Tianjin Hospital in Tianjin, China, showed:

  • Tumors with low leve
    '/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Nurses at forefront of genomics in health care
2. Genomic sequencing identifies mutant drivers of common brain tumor
3. Epigenomic abnormalities predict patient survival in non-Hodgkins lymphoma
4. When will genomic research translate into clinical care -- and at what cost?
5. NIH grant moves pathologists to the forefront of genomic medicine
6. Stanford/Yale study gives insight into subtle genomic differences among our own cells
7. Study shows large-scale genomic testing feasible, impacts therapy
8. Ontario Genomics Institute invests in stem cell technology at Tissue Regenerative Therapeutics
9. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
10. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
11. $8.9 million NIH grant to study genomic link to premature heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Deep genomic analysis identifies a micro RNA opponent for ovarian cancer
(Date:12/25/2014)... December 26, 2014 The ... combines beauty, strength and durability. Today, the business ... which is valid until Jan. 30, 2015. , ... of traditional hardwood. BambooFlooringChina.com is a well-known brand ... consumers worldwide to find a reliable bamboo flooring ...
(Date:12/25/2014)... 26, 2014 “Every three months the trends ... A-line sweetheart evening dress will be one of the hottest ... of Yunx.co.uk says. Today, the company releases 26 A-line sweetheart ... to 80% off. , “We are trying our best ... with our latest designs. Along with affordable prices, we provide ...
(Date:12/25/2014)... Recently, BellasDress has launched its Christmas Sale, ... has chosen their best-selling lace wedding dresses, vintage bridesmaid ... season. , Now, BellasDress.com features popular women’s dresses, ... discount prices. The business hopes everyone can have a ... , “All our elegant products are made with exquisite ...
(Date:12/25/2014)... updated its blog to provide professional shopping tips on wedding and ... LunaDress.co.uk come with big discounts, up to 80 percent off. , ... to be a most exciting memory and can show off a ... a wedding. On the updated fashion blog, ladies can now find ... day . , Going out with friends to a party is ...
(Date:12/25/2014)... Dec. 24, 2014 (HealthDay News) -- Among early stage ... less than half of one percent will eventually develop ... analysis reveals. The finding comes from a review ... 1998 and 2007, and it suggests that the risk ... what experts had previously thought. "The frequency of ...
Breaking Medicine News(10 mins):Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... 2007) Lower muscle mass and an increase in body ... exercise is a proven way to prevent the loss of ... Mark Tarnopolsky shows that taking a combination of creatine monohydrate ... exercise training provides even greater benefits. , The ...
... 2 Speaker Nancy Pelosi,released the following statement ... The Speaker was presented the National Breast,Cancer Coalition,s ... York City last,night: "National Breast Cancer Awareness ... and to recommit ourselves to advancing prevention, improving,treatments, ...
... imagine iPhones, laptops and flash drives. But more ... a newly updated inventory of nanotechnology consumer products ... and health products. , Maintained by the ... inventory includes Head NanoTitanium Tennis Racquets, Eddie Bauer ...
... is a statement,by Linda A. Suydam, D.P.A., president ... to inaccurate and misleading media reports,surrounding the U.S. ... Nonprescription Drugs Advisory Committee and Pediatric Advisory,Committee scheduled ... the makers of pediatric, over-the-counter cough and cold,medicines ...
... WASHINGTON, Oct. 2 Speaker Nancy Pelosi and,Senate Majority ... sending President Bush the Children,s Health Insurance,Program (CHIP) legislation:, ... a bipartisan bill,to insure 10 million of our nation,s ... American people that the President will sign the bill ...
... Offer Both Suspension and Tablet Forms, PRINCETON, N.J., ... subsidiary of Ranbaxy Laboratories Limited (RLL),announced today that RLL ... Administration (U.S. FDA) to manufacture and market Clarithromycin for,Oral ... Ranbaxy is the first,company to have been granted a ...
Cached Medicine News:Health News:Nanotechnology: not just for geeks 2Health News:Statement from the Consumer Healthcare Products Association on the Safety of Pediatric Over-the-Counter Medicines 2Health News:Ranbaxy First to Gain Approval to Manufacture and Market Clarithromycin for Oral Suspension, USP 2
(Date:12/24/2014)... Dec. 23, 2014 Echo Therapeutics, Inc. ... company focused on skin permeation, continuous glucose monitoring ... W. Hollander has been appointed Chief Executive ... more than 20 years of experience in the ... most recently served as Vice President, Business Development, ...
(Date:12/24/2014)... Dec. 23, 2014   Synageva BioPharma Corp. ... company developing therapeutic products for rare disorders, today ... of the Marketing Authorization Application (MAA) for sebelipase ... the company,s request for accelerated assessment, which has ... time.   The MAA, and the ...
(Date:12/24/2014)... China , Dec. 23, 2014 ... pharmaceutical company that specializes in patented biopharmaceutical, modernized ... pharmaceutical ingredients (API) today announced that the Company ... its Good Manufacturing Practice (GMP) certificate of TPI,s ... Drug Administration,s (CFDA). The public notice period is ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3
Suitable for mild to moderate ACL and/or PCL, MCL and LCL instabilities, this neoprene brace with extended hinge bars is an ideal intermediate-level product that can be used in sporting activities. C...
Provides range-of-motion control for both flexion and extension along with a drop lock feature...
Provides comfortable compression, support and immobilization for the knee...
Dynamic brace that provides a low load, prolonged stretch to the connective tissue around the joint using an adjustment hinge with a built-in tension spring...
Medicine Products: