Navigation Links
Deep genomic analysis identifies a micro RNA opponent for ovarian cancer
Date:2/11/2013

nts, we would need to do formal safety testing before moving it into clinical trials," Sood said.

Ovarian cancer is the most lethal gynecologic cancer in the United States, with an estimated 22,280 cases diagnosed in 2012 and 15,460 deaths. Ovarian cancer is often diagnosed at an advanced stage and it also has greater capacity to spread than most other solid tumors.

New analysis of The Cancer Genome Atlas data

Based on gene expression data from 489 high-grade serous ovarian carcinoma patients, TCGA's initial study published in Nature divided these patients into four categories but found no survival differences among the groups.

Zhang, who is co-director of a TCGA genomics center, and colleagues applied additional analyses to better understand the TCGA category of mesenchymal ovarian cancer. Most solid tumors are carcinomas, meaning that they start in the lining (epithelium) of the organ. Emerging evidence, Zhang noted, connects ovarian cancer cell invasiveness and spread to a loss of epithelial features and a gain of mesenchymal features, known as epithelial to mesenchymal transition.

There are a number of significant differences between the two types of cell. One is mobility: epithelial cells are designed to stay put and are likely to die in a variety of ways if they break away from the primary tumor. Mesenchymal cells can move about. They also rely on distinctive protein biomarkers.

The search narrows, from 2,942 genes to one miRNA

The researchers used additional data from the TCGA group - alterations of gene copy number, miRNA expression and DNA methylation, which silences genes - and re-analyzed the 489 patients.

"With those data, we were able to identify a subtype of ovarian cancer, look deeply into the mechanism behind it and identify regulators of that type so we can develop new treatments," said co-lead author Da Yang, Ph.D., an MD Anderson Odyssey Scholar in the pathology department
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Nurses at forefront of genomics in health care
2. Genomic sequencing identifies mutant drivers of common brain tumor
3. Epigenomic abnormalities predict patient survival in non-Hodgkins lymphoma
4. When will genomic research translate into clinical care -- and at what cost?
5. NIH grant moves pathologists to the forefront of genomic medicine
6. Stanford/Yale study gives insight into subtle genomic differences among our own cells
7. Study shows large-scale genomic testing feasible, impacts therapy
8. Ontario Genomics Institute invests in stem cell technology at Tissue Regenerative Therapeutics
9. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
10. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
11. $8.9 million NIH grant to study genomic link to premature heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Deep genomic analysis identifies a micro RNA opponent for ovarian cancer
(Date:5/5/2015)... 05, 2015 BioFit Engineered Products ... will feature models from its two latest lines at ... Mart in Chicago. Headlining the company’s exhibit will be ... seating line, as well as the unveiling of the ... BioFit president Ed Metzger will deliver in-booth presentations each ...
(Date:5/5/2015)... With the advent of spring, thoughts turn to shedding bulky ... on bare skin. And with those thoughts both men and ... in shorts, tank tops and bikinis, particularly how to remove ... treatments for permanent hair removal,” says Jayme Bashian, director and ... “They're all veterans of shaving, waxing, tweezing, and depilatories, none ...
(Date:5/5/2015)... San Diego, CA (PRWEB) May 05, 2015 “We ... men and women,” states Marta Phillips, owner of SunGrubbies.com. “We ... have in trying to find a fashionable sun hat in an ... a dressy outdoor event.” , Fashionable derby sun hats ... Braid 7 inch brim are now available in an extra ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 There have ... these have focused primarily on personal lines (home, auto, ... Directory of Insurance (NDOI.com) has created an online ... in the U.S. to present their expertise in all ... The result is significant and two-fold. , First, the ...
(Date:5/5/2015)... New York, NY (PRWEB) May 05, 2015 ... problems. The Centers for Disease Control and Prevention ... it effects our everyday life: “Poor indoor air quality (pollution) ... lead to chronic heart and lung problems and cancer.” , ... them, swallow them in contaminated food or water, or in ...
Breaking Medicine News(10 mins):Health News:BioFit to Introduce New Models from Latest Specialized Ergonomic Seating Lines at NeoCon 2015 2Health News:BioFit to Introduce New Models from Latest Specialized Ergonomic Seating Lines at NeoCon 2015 3Health News:Laser Hair Removal: Tips for Summertime Grooming 2Health News:Laser Hair Removal: Tips for Summertime Grooming 3Health News:SunGrubbies.com, a Leading Online Retailer of Sun Protection Products, Launches Their New Extra Large Size Fashion Sun Hats Collection 2Health News:NDOI Launch Brings Commercial Insurance Online for the First Time 2Health News:NDOI Launch Brings Commercial Insurance Online for the First Time 3Health News:revitaRUGS is Offering Area Rug Cleaning Discounts in Support of Asthma and Allergy Awareness Month This May 2Health News:revitaRUGS is Offering Area Rug Cleaning Discounts in Support of Asthma and Allergy Awareness Month This May 3
... ROCKVILLE, Md., July 29 Sanaria Inc., ... the University of,Maryland Biotechnology Institute (UMBI) announced ... Research (SBIR) Grant from the,National Institute of ... Institutes of Health. The grant will support ...
... Medical Center of Santa Rosa, SANTA ROSA, Calif., ... United Healthcare Workers - West:, Healthcare workers will ... alarm at a growing healthcare crisis in Sonoma,County that ... next,month. The announced elimination of 120 SMCSR workers would ...
... Age, cyberinfrastructure the organized aggregate of information technologies, ... research advancement and discovery. In this month,s ... Diego Supercomputer Center (SDSC) at the University of California, ... as part of the "IT bill" for the Information ...
... people moving, study finds , , TUESDAY, July 29 (HealthDay ... waistlines trim, U.S. researchers report. , "We were excited ... diverse destinations -- living in an older neighborhood and ... both predict lower weight," said lead researcher Barbara Brown, ...
... Gillette, brings 38 years of ... experience in consumer products industry, CHICAGO, July 29 ... Peter Klein has joined the,firm as a director., Mr. ... products,industry and was most recently senior vice president and corporate ...
... OF ALL AMERICANS will be diagnosed at some point in ... United States. One of the professions at the frontlines in ... use the power and innovation of physics to study and ... to develop new imaging technologies, such as dedicated breast CT ...
Cached Medicine News:Health News:Malaria Vaccine Developer Sanaria Inc. and the University of Maryland Biotechnology Institute Awarded Collaborative, Multi-Year, US $600,000 NIH Phase I Small Business Innovation Research Grant 2Health News:Malaria Vaccine Developer Sanaria Inc. and the University of Maryland Biotechnology Institute Awarded Collaborative, Multi-Year, US $600,000 NIH Phase I Small Business Innovation Research Grant 3Health News:Workers Denounce Sutter Health's Disregard for Community Interests 2Health News:San Diego Supercomputer Center director urges academia to make cyberinfrastructure 'real' 2Health News:Walkable Neighborhoods Keep the Pounds Off 2Health News:The Cambridge Group Names Peter Klein a Director 2Health News:Cancer research highlights 2Health News:Cancer research highlights 3Health News:Cancer research highlights 4Health News:Cancer research highlights 5Health News:Cancer research highlights 6Health News:Cancer research highlights 7Health News:Cancer research highlights 8Health News:Cancer research highlights 9Health News:Cancer research highlights 10Health News:Cancer research highlights 11Health News:Cancer research highlights 12Health News:Cancer research highlights 13Health News:Cancer research highlights 14Health News:Cancer research highlights 15Health News:Cancer research highlights 16Health News:Cancer research highlights 17
(Date:5/4/2015)... -- Former NASA scientist Tamim Hamid was ... discussed Theradome™, the first portable and wearable OTC hair ... firsthand how, via laser technology, Theradome™ offers individuals a ... not require surgery or medication.  "The ... the hair follicle, which is where the stem cells ...
(Date:5/4/2015)... May 4, 2015 PAREXEL International Corporation (NASDAQ: ... the UBS Healthcare Conference on Monday, May 18, 2015, in ... and Chief Financial Officer will be making a presentation on ... A live webcast of the presentation will be available ... in the Upcoming Events portion of the main page, ...
(Date:5/4/2015)... , May 4, 2015 Rogne Bioscience, ... psoriasis, today announced that preclinical and mechanism of action ... the Society of Investigative Dermatology (SID) Annual Meeting being ... Atlanta, Georgia . Logo - ... the development of RON2315, a novel, low MW (<1700 ...
Breaking Medicine Technology:FOX News Features Theradome as the Take-Home Solution to Tackle Baldness 2PAREXEL International to Present at UBS Healthcare Conference 2Rogne Bioscience to Present Data from Topical Biologic Psoriasis Program at Upcoming SID Annual Meeting 2015 2
... , POINT RICHMOND, Calif., Nov. 12 Transcept Pharmaceuticals, ... focused on the development and commercialization of proprietary products ... financial results for the three and nine months ended ... that on October 28, 2009, the FDA issued a ...
... / -- New research findings presented today ... International Conference in New York show promise in ... alternative medicine (CAM) using traditional research methods. Susan ... and Clinics of Minnesota (Children,s), presented findings on ...
Cached Medicine Technology:Transcept Pharmaceuticals Reports Third Quarter 2009 Financial Results 2Transcept Pharmaceuticals Reports Third Quarter 2009 Financial Results 3Transcept Pharmaceuticals Reports Third Quarter 2009 Financial Results 4Transcept Pharmaceuticals Reports Third Quarter 2009 Financial Results 5Transcept Pharmaceuticals Reports Third Quarter 2009 Financial Results 6Transcept Pharmaceuticals Reports Third Quarter 2009 Financial Results 7Transcept Pharmaceuticals Reports Third Quarter 2009 Financial Results 8Transcept Pharmaceuticals Reports Third Quarter 2009 Financial Results 9Transcept Pharmaceuticals Reports Third Quarter 2009 Financial Results 10Transcept Pharmaceuticals Reports Third Quarter 2009 Financial Results 11Transcept Pharmaceuticals Reports Third Quarter 2009 Financial Results 12New Research Shows Promise in Using Traditional Research Methods to Assess Efficacy of Complementary Therapies 2
... medication nebulizer achieves optimum lung penetration for ... range is 1.04-1.10 µ at 6-8 LPM. ... outlet., ,As the world leader in ... the assurance of proven technology by offering ...
... breakthrough continuous low-flow nebulizer performance. Patented ... technology allows for optimal medication and ... Heliox). OMNI~NEB takes on severe asthma, ... and critical care situations. Configure with ...
... offer a spill-proof design and effective output, ... angle. All medical nebulizers are free-standing for ... configurations are available., ,All Portex® medication ... medication nebulizers feature consistently fine misting and ...
... a spill-proof design and effective output, even ... All medical nebulizers are free-standing for easy ... are available., ,All Portex® medication nebulizer ... nebulizers feature consistently fine misting and the ...
Medicine Products: