Navigation Links
Deep brain stimulation may improve memory
Date:1/29/2008

Deep brain stimulation (DBS) surgery, which is used to treat Parkinsons disease and other movement disorders, is now being studied for its potential to treat a variety of conditions. For example, DBS of the hypothalamus has been used to treat cluster headaches and aggressiveness in humans, and stimulating this area influences feeding behavior in animals. A new study found that hypothalamic DBS performed in the treatment of a patient with morbid obesity unexpectedly evoked detailed autobiographical memories. The study will be published online in the Annals of Neurology (http://www.interscience.wiley.com/journal/ana), the official journal of the American Neurological Association.

Led by Andres Lozano, Professor of Neurosurgery and Canada Research Chair in Neuroscience and his team at the Toronto Western Hospital in Toronto, Ontario, researchers conducted an experimental study to treat a 50-year-old man with a lifelong history of obesity in whom a variety of treatment approaches had failed. While they were identifying potential appetite suppressant sites in the hypothalamus by stimulating electrode contacts that had been implanted there, the patient suddenly experienced a feeling of dj vu. He reported the perception of being in a park with friends from when he was around 20 years old and as the intensity of the stimulation was increased, the details became more vivid. These sensations were reproduced when the stimulation was performed in a double-blinded manner. The contacts that most readily induced the memories were located in the hypothalamus and estimated to be close to the fornix, an arched bundle of fibers that carries signals within the limbic system, which is involved in memory and emotions. Stimulation was shown to drive the activity the temporal lobe and the hippocampus, important components of the brains memory circuit.

At the first office visit two months after the patient was released from the hospital, the researchers were able to induce and videotape the memory effects seen in the operating room by turning on the electrical stimulation. They also tested the patients memory during and without stimulation and found that after three weeks of continuous hypothalamic stimulation he showed significant improvements in two learning tests. In addition, the patient was much more likely to remember unrelated paired objects when stimulation was on than when it was off. They conclude that just as DBS can influence motor and limbic circuits, it may be possible to apply electrical stimulation to modulate memory function and, in so doing, gain a better understanding of the neural substrates of memory.


'/>"/>

Contact: Amy Molnar
amolnar@wiley.com
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. CSHL scientists make progress in determining how the brain selectively interprets sound
2. Amalgam Fillings Dont Affect Childrens Brain Development, Says Study in ADA Journal
3. Amalgam fillings dont affect childrens brain development, says study in ADA Journal
4. Varian and BrainLAB Announce Rapid Uptake of Powerful and Versatile Radiosurgery Platform
5. Specific Brain Region Governs Problem-Solving Skills
6. Researchers identify brains eureka circuitry
7. Study: Brain connections strengthen during waking hours, weaken during sleep
8. DNA Fingerprints Predict Brain Disorders
9. Combo Therapy Shows Promise in Treating Brain Tumors
10. Combined radiation seed, chemotherapy wafer implants show promise in treating cancerous brain tumors
11. Study finds significant differences in protocols hospitals use to determine brain death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... ... improved supplement, Healthful-Flex. , The company, owned and operated by Ed Stroup, ... at a reasonable price with the highest level of customer service. Healthful Balance ...
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... ... as well as Palm Desert, is opening a new office in San Clemente, ... transcranial magnetic stimulation (dTMS) in Southern California, successfully treating individuals struggling with major ...
(Date:1/17/2017)... ... January 17, 2017 , ... A prescription medication bottle, ... the fourth Cradle to Cradle Product Design Challenge , the Cradle to ... series of six circular design challenges scheduled to run through early 2018. The challenges ...
(Date:1/17/2017)... Gatos, CA (PRWEB) , ... January 17, 2017 , ... ... announced the results of a double blind clinical study for its dental gel that ... a leading national brand of toothpaste containing triclosan. The study was conducted at the ...
(Date:1/17/2017)... ... ... people make New Year’s resolutions or renew their commitment to better health with the start ... who want to kick off 2017 with better smiles. Dr. Mondavi is offering several promotions ... include: , , A new patient package for just $49, which ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... , Jan. 17, 2017   Anesthesia Business ... and practice management for the anesthesia and pain ... which remains a "clinical conundrum" (as described recently ... pain practitioners to think carefully before recommending medical ... report by the National Academies of Sciences, Engineering ...
(Date:1/17/2017)... NEW YORK , Jan. 17, 2017 ... clinical stage biopharmaceutical company, announced today that it will ... International Symposium on Acute Leukemias (ISAL) XVI in ... symposium is entitled:  "Reinforcing the Efficacy of Immunotherapy for ... will take place on Monday February 20 th , 2017 ...
(Date:1/17/2017)... Ind. , Jan. 17, 2017  Zimmer Biomet ... in musculoskeletal healthcare , today announced that ... on the strength of the Zimmer Biomet management ... Delp will assume the position of President, ... the Company. Mr. Delp previously served as Zimmer Biomet,s ...
Breaking Medicine Technology: