Navigation Links
Deep Brain Stimulation Works in Two Sites for Parkinson's Disease

Choice of area to pinpoint can be tailored to individual patients, researchers say ,,

WEDNESDAY, June 2 (HealthDay News) -- People suffering from Parkinson's disease can benefit from deep brain stimulation in either one of two sites in the brain, a new study finds.

The Veterans Affairs researchers compared two different targets in the brain for deep brain stimulation -- the subthalamic nucleus (STN) and the globus pallidus interna (GPi) -- both of which affect motor function. The procedure involves placing a fine wire into either of the two areas, after which an implanted battery delivers a finely tuned electrical current to stimulate the brain, often resulting in dramatic improvement in motor function.

"Most of the neurosurgery field has been using the STN target, with little strong evidence that it was the best target for stimulation," said researcher Frances Weaver, director of the Center for Management of Complex Chronic Care at Hines VA Hospital in Illinois.

"But recent reports suggest that there may be some negative consequences of STN targeting, including cognitive and psychological changes," she added.

The report is published in the June 3 issue of the New England Journal of Medicine.

For this study, researchers compared the STN and GPi targets in a randomized trial and looked at patient outcomes. In the trial, 299 patients were assigned to either STN or GPi deep brain stimulation.

Weaver's team found that patients improved equally in motor function, regardless of which target was used.

Overall, about half of the patients had serious side effects. The most common was infection at the incision site. By the end of the two-year study, 99 percent of these side effects were resolved.

"The decision as to which target in the brain to stimulate to treat Parkinson's disease should consider the other symptoms and problems of Parkinson's disease," Weaver said. For example, the use of medications can be reduced to a greater extent after STN stimulation than GPi stimulation, she noted.

"Medication has effects on other symptoms, so if a patient is experiencing other symptoms besides motor problems that are better managed by medication, you may want to select the GPi -- where less reduction in medication is necessary," Weaver said.

Both STN and GPi deep brain stimulation are equally effective in improving motor symptoms in people with advanced Parkinson's disease, Weaver said.

"Serious adverse events are frequent for both targets, but are resolved through stimulation or medication adjustments, and other interventions, as needed," she added.

Dr. Michael Okun, national medical director of the National Parkinson Foundation, said that "this is an important study for Parkinson's disease patients and for their doctors as it opens the door for tailoring therapy and for tailoring brain targets for individual symptom profiles."

He added: "This two-year prospective randomized study showed that both STN and GPi were effective in treating the motor symptoms of Parkinson's disease, and that there were subtle but potentially important differences between targets."

The first signs of Parkinson's are usually motor control problems such as shaking, rigidity, slowed movement and poor balance. In later stages, patients develop a variety of cognitive and mood problems, including depression, apathy, slowed thinking, confusion, impaired memory and trouble sleeping.

In early stages of the disease, motor symptoms can be controlled by medications such as L-dopa. But for patients with advanced Parkinson's, the drugs are less effective.

More information

For more information on Parkinson's disease, visit the National Parkinson Foundation.

SOURCES: Frances Weaver, Ph.D., director, Center for Management of Complex Chronic Care, Hines VA Hospital, Hines, Ill.; Michael Okun, M.D., national medical director, National Parkinson Foundation; June 3, 2010, New England Journal of Medicine

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New Hope for Brain, Spinal Cord Injuries
2. UPMC Health Plan Offers Brain Fitness Software to Improve Health
3. NFL Brain Injury Panel Raises Awareness of Potential Long-Term Consequences from Traumatic Brain Injuries
4. Melatonin precursor stimulates growth factor circuits in brain
5. Brain Scans Suggest Some Vegetative Patients May Be Aware
6. Brain Damage Seen in People With Severe Sleep Apnea
7. Alterations in the brains reward system related to attention-deficit/hyperactivity disorder
8. Brain dopamine receptor density correlates with social status
9. 3 brain diseases linked by toxic form of same neural protein
10. Brain Damage: NFL ‘Gets It,' American Society of Anesthesiologists Still Appears ‘Asleep'
11. Study finds reduced brain gray matter concentration in patients with severe obstructive sleep apnea
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... Though trick-or-treating remains ... confines of their home. Whether it's making fun pre or post trick-or-treat snacks ... Florida Dairy Farmers. , Recipe 1: Green Chile Queso Dip with Sriacha ...
(Date:10/13/2015)... ... (PRWEB) ... (MOAA) will hold its 2015 annual meeting and corresponding events ... career fair; informational seminars; a luncheon featuring keynote speaker Air ... of Staff; and the Community Heroes Award Night, which recognizes ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... new Pillars of Excellence in the Life Sciences Initiative aimed at enhancing Purdue’s ... recently announced $2 billion “Ever True” capital campaign. , The investment will result ...
(Date:10/13/2015)... ... 13, 2015 , ... Sir Grout of Greater Boston donated an expansive, seven ... Ronald McDonald House Charities® (RMHC®). This donation was made in an effort to give ... since its inception. , “We believe strongly in the Ronald McDonald House Charities, and ...
(Date:10/13/2015)... ... 13, 2015 , ... Califia Farms , one of ... release of its limited edition holiday seasonal flavors: Almondmilk Holiday Nog, new Peppermint ... unique flavor combinations and delicious taste Califia Farms’ beverages are known for, without ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 13, 2015   Generational Equity , a leading ... pleased to announce the acquisition of its client, ... Largo, Florida , by Meridian Biomedical, Inc. (Meridian), ... 2015. Florida . To ... Florida . To learn more, visit ...
(Date:10/13/2015)...  Kay Elledge, M.D., an established South Bay ... Obstetrics and Gynecology (FACOG) for the past 21 ... Self Medical Laser Center where she provides laser ... Breast Cancer Awareness Month , the Center ... Touch treatments initiated in the month of ...
(Date:10/13/2015)... 2015 According to the 2015 ... by Cardinal Health , achieving both higher ... pharmacy revenue streams are vital to the future ... NCPA Digest affirms that independent community pharmacies ... underserved inner city and rural areas," said NCPA ...
Breaking Medicine Technology: