Navigation Links
Deep, integrated genomic analysis re-classifies lower-grade brain tumors
Date:4/8/2014

Comprehensive genomic analysis of low-grade brain tumors sorts them into three categories, one of which has the molecular hallmarks and shortened survival of glioblastoma multiforme, the most lethal of brain tumors, researchers reported at the American Association for Cancer Research Annual Meeting 2014.

"The immediate clinical implication is that a group of patients with tumors previously categorized as lower grade should actually be treated as glioblastoma patients and receive that standard of care -- temozolomide chemotherapy and irradiation," said lead author Roel Verhaak, Ph.D. assistant professor of Bioinformatics and Computational Biology at The University of Texas MD Anderson Cancer Center.

"Classifying lower grade tumors in these three molecular clusters more accurately characterizes them than current methods used to group and grade tumors," Verhaak said.

The pivotal molecular markers that define the three tumor clusters mutational status of the IDH1 and IDH2 genes and loss of chromosome arms 1p and 19q -- are already routinely checked in clinical care, Verhaak noted, so implementing the new categories can be done relatively quickly.

Verhaak and colleagues analyzed data from The Cancer Genome Atlas (TCGA) brain tumor studies.

Lack of IDH1/2 mutations drastically reduces survival

Brain tumors arise in the glia, or supportive cells, of the brain and now are classified by their histology characteristics visible via microscopy and their cell of origin, either astrocytes or oligodendrocytes.

Classified this way, grade 2 and 3 oligodendrogliomas and astrocytomas demonstrate median overall patient survival ranging from three to ten years. This compares with 14 months for patients with glioblastoma multiforme a complex and aggressive astrocytoma.

Glioblastomas make up 55-60 percent of gliomas, with lower-grade astrocytomas comprising 15-20 percent of cases, oligodendrocytes
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Best Christmas Gift for 2012: Instant Stress Relief on CD! Relaxintuit.com’s Award-Winning Meditation CD Soothes Anxiety, Depression, Pain & Supports Deep, Healthy Sleep
2. Qualicode and CellTrak Deliver Integrated Mobile Scheduling and Health Record Solution
3. Offenders need integrated, on-going, mental health care
4. Integrated Services Becomes Preferred Rental Provider for Rural/Metro Corporation
5. Physician-Patient Alliance for Health & Safety: The Path to a Safer PCA Pump - Improving Patient Safety with Integrated Capnography
6. Serious games could be integrated into surgical training subject to validation
7. Integrated diabetes management program provides rapid improvements in patient care
8. Beta Testing Opportunity for URAC Clinically Integrated Network Accreditation Program
9. Integrated neglected tropical disease control and elimination programs: A global health best buy
10. Instrument handle with integrated electronics facilitates surgical procedures
11. Delray Recovery Center Kickstarts Treatment with Integrated Recovery Program by CrossFit
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Deep, integrated genomic analysis re-classifies lower-grade brain tumors
(Date:8/1/2015)... ... 2015 , ... Lume Wellness creators Alex, Robert, and Sam have announced update ... AppStore. , The app is designed to track various metrics of wellness, including ... view personal health and use this information for positive behavior modification. Lume Wellness keeps ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reputable source of authentic tickets for ... Arena. Fans of every genre of music will have an act they are excited ... of the festival, the following artists will perform: Sam Smith, Coldplay, Kenny Chesney, The ...
(Date:7/31/2015)... , ... July 31, 2015 , ... Precision Aesthetics is ... years. It was also the first provider of Exilis non-surgical fat reduction in ... after procedures it has attracted a large International clientele. Many patients travel to ...
(Date:7/31/2015)... ... July 31, 2015 , ... There’s no better way to enjoy the ... time to cook the next meal, making July the most appropriate to be National ... tips and recipes. , Make the next cookout different than the ones in the ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reliable source ... to catch a new and refreshing show on Broadway, look no further than Hamilton. ... an Obie Award, Outer Critics Circle Award, Drama Desk Award, Lucille Lortel Award, and ...
Breaking Medicine News(10 mins):Health News:Lume Wellness Launches Health and Fitness Tracker iPhone App 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 4Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 5Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 6Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 7
... Scientists at Duke University Medical Center may have solved the ... they say may renew interest in gold salts as a ... first used injections of gold salts in the early 1900s ... But treatment came at a high cost: The shots ...
... 22 With health,facilities across the country struggling ... Veterans Affairs (VA) are demonstrating leadership by,collaborating in ... the federal healthcare supply chain. Through the innovative ... and expanding their ongoing,initiatives to both standardize and ...
... of virus in the blood of an HIV-infected personhas ... quickly someone infected with HIV infection progresses to AIDS. ... work that suggests that several other factors in addition ... , Researchers led by Sunil Ahuja, M.D., of the ...
... , , MONDAY, Oct. 22 (HealthDay News) -- If you,re sneaking ... a common device can determine whether someone is a smoker. ... to ferret out people who hide a cigarette habit, ... patients what smoking is doing to their bodies, he added. ...
... vascular surgery, picks up size 7 crochet hooks from a fabric ... in a new technique he has developed to treat varicose veins. ... procedure, called light-assisted stab phlebectomy, or LASP, appear in a study ... , More than 250 patients at UCLA have ...
... Information,Systems (Nasdaq: MEDW ) announced today that ... licensed Mediware,s HCLL(TM) Transfusion,Management software system, which provides ... transfusion errors, improve patient,safety and maximize operational efficiency. ... is based in Dallas, Texas, and,through its subsidiaries, ...
Cached Medicine News:Health News:Scientists discover how gold eases pain of arthritis 2Health News:DoD and VA to Reduce Healthcare Supply Chain Costs 2Health News:DoD and VA to Reduce Healthcare Supply Chain Costs 3Health News:DoD and VA to Reduce Healthcare Supply Chain Costs 4Health News:Blood Test Catches Secret Smokers 2Health News:Blood Test Catches Secret Smokers 3Health News:UCLA doctor develops new technique to treat varicose veins 2Health News:UCLA doctor develops new technique to treat varicose veins 3Health News:Mediware's Transfusion Management Software Adopted by Four Additional Tenet Hospitals 2Health News:Mediware's Transfusion Management Software Adopted by Four Additional Tenet Hospitals 3
(Date:7/31/2015)... 31, 2015  Seeger Weiss LLP is reporting that on ... warning letter to C.R. Bard, the manufacturer of Inferior ... to correct violations the agency found at two of Bard,s ... the FDA cited them during Inspectional Observations that occurred on ... Tempe, AZ , location and on October 6, ...
(Date:7/31/2015)... July 31, 2015 RnRMarketResearch.com ... market research report that provides an overview of ... data sourced from in-house databases, secondary and primary ... needles market products pipeline spread across 124 pages, ... 73 tables and 5 figures is now available ...
(Date:7/31/2015)... , July 31, 2015 According ... by Product (Moist Heat, Dry Heat, Ethylene Oxide, Filtration, E-beam, ... End User (Hospitals, Pharmaceuticals) - Global Forecast to 2020", published ... around USD 6.1 Billion by 2020, at a CAGR of ... 242 market data T ables and ...
Breaking Medicine Technology:Seeger Weiss LLP Reports That The FDA Has Issued A Warning Letter To IVC Filter Manufacturer, C.R. Bard 2Seeger Weiss LLP Reports That The FDA Has Issued A Warning Letter To IVC Filter Manufacturer, C.R. Bard 3Syringes and Needles Market Products Pipeline Review 2015 Report 2Syringes and Needles Market Products Pipeline Review 2015 Report 3Syringes and Needles Market Products Pipeline Review 2015 Report 4Syringes and Needles Market Products Pipeline Review 2015 Report 5Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 2Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 4
... Zimmer Holdings, Inc. (NYSE and SIX: ZMH) today ... December 31, 2010.  The Company reported fourth quarter net ... and 3.0% constant currency over the fourth quarter of ... $0.18 reported and $1.27 adjusted, an increase of 13.4% ...
... Ill., Jan. 27, 2011 Fenwal, Inc., a global medical ... availability, announced today the names of 16 inspiring individuals inducted ... For more than a decade, Fenwal has partnered ... an inspiration to others in assuring medicine,s most vital natural ...
Cached Medicine Technology:Zimmer Reports Fourth Quarter and 2010 Financial Results 2Zimmer Reports Fourth Quarter and 2010 Financial Results 3Zimmer Reports Fourth Quarter and 2010 Financial Results 4Zimmer Reports Fourth Quarter and 2010 Financial Results 5Zimmer Reports Fourth Quarter and 2010 Financial Results 6Zimmer Reports Fourth Quarter and 2010 Financial Results 7Zimmer Reports Fourth Quarter and 2010 Financial Results 8Zimmer Reports Fourth Quarter and 2010 Financial Results 9Zimmer Reports Fourth Quarter and 2010 Financial Results 10Zimmer Reports Fourth Quarter and 2010 Financial Results 11Zimmer Reports Fourth Quarter and 2010 Financial Results 12Zimmer Reports Fourth Quarter and 2010 Financial Results 13Zimmer Reports Fourth Quarter and 2010 Financial Results 142010 Inductees to the Fenwal Blood Donation Hall of Fame 22010 Inductees to the Fenwal Blood Donation Hall of Fame 3
... Plus is an easy to use, full color Autofocus ... (either a computer or a television) sits on top ... It has a built in SVGA adapter allowing it ... magnified image from the video magnifier is displayed on ...
... Flipper's innovative rotating camera design enables people ... more effectively. By rotating the camera head, ... magnified images at any distance. Flipper is ... one area to another. Simply roll the ...
... remarkable new electronic magnification system. It was ... macular degeneration patient in mind. PVA contains ... to allow you to see your face ... a 350,000 pixel full color camera. It ...
... Thelco general purpose incubators ... temperature control and uniformity required ... applications. These versatile microprocessor controlled ... selection, an easy-to-read digital display, ...
Medicine Products: