Navigation Links
Decreasing cancer risk associated with inflammatory bowel disease
Date:7/9/2012

Inflammatory bowel disease is caused by chronic inflammation , which leads to damage of the intestinal epithelium. Patients with inflammatory bowel disease have an elevated risk for developing colorectal cancer because of this chronic inflammation. In an effort to develop strategies to break the cycle of inflammation, Dr. Brent Polk and colleagues at the University of Southern California in Los Angeles examined two mouse models of colorectal cancer. Their work shows that inactivating a key receptor, known as epidermal growth factor receptor, increases the frequency and severity of colorectal tumors. Though epidermal growth factor has well-defined roles in promoting tumor growth, the Polk team now finds that epidermal growth factor receptor can ameliorate the response to chronic inflammation and reduces tumor development by fine-tuning inflammation and the generation of intestinal epithelium. Their results suggest that promoting epidermal growth factor activity in patients with inflammatory bowel disease could decrease long-term cancer risk by reducing inflammation.

TITLE:
Epidermal growth factor receptor inhibits colitis-associated cancer in mice

AUTHOR CONTACT:
D. Brent Polk
University of Southern California and Childrens Hospital Los Angeles, Los Angeles, CA, USA
Phone: 323-361-2278; E-mail: dbpolk@chla.usc.edu

View this article at: http://www.jci.org/articles/view/62888?key=ab673ae8215aaf449677


'/>"/>

Contact: Sarah Jackson
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Better treatment for brain cancer revealed by new molecular insights
2. Researchers find new target deep within cancer cells
3. Cell differentiation as a novel strategy for the treatment of an aggressive type of skin cancer
4. Ovarian Transplants May Preserve Fertility in Young Cancer Survivors
5. Fertility drug usage and cancer risk
6. Scientists develop mouse model that could lead to new therapies for liver cancer
7. Can Fertility Treatments Influence Later Breast Cancer Risk?
8. Worlds fastest camera, created by UCLA engineers, used to detect rogue cancer cells
9. Loss of protein SPDEF allows prostate cancer cells to gain foothold at possible sites of metastasis
10. UCLA bioengineers discover single cancer cell can produce up to 5 daughter cells
11. ASTRO, the Center for Cancer Support and Education to promote cancer survivorship
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/17/2017)... KOREA (PRWEB) , ... July ... ... receipt of CE marking for its faster PICOPLUS 450 ps pulse width ... picosecond- and nanosecond-domain 1,064-nm neodymium-doped yttrium-aluminum-garnet lasers in tissue-mimicking phantom’ featured in ...
(Date:7/17/2017)... ... July 17, 2017 , ... Summer camp season ... to ensure children are protected from Lyme and other tick-borne diseases. , With ... an increased risk not only for the tick-borne illness, but for its various ...
(Date:7/17/2017)... ... July 17, 2017 , ... HMP , a ... with the Texas Academy of Family Physicians (TAFP) for the 6th ... at the Hyatt Regency Dallas in Dallas, Texas.     , CRS and TAFP will ...
(Date:7/17/2017)... ... 17, 2017 , ... Jordan Search Consultants (JSC), a national ... for Springfield Clinic’s Chief Executive Officer (CEO) in Springfield, IL. Working with JSC ... with more than 30 years of experience, as the new CEO. , ...
(Date:7/17/2017)... Aliso Viejo, CA (PRWEB) , ... July 17, 2017 , ... ... Pro X. These minimalistic layouts can be used to complement vlogs, professional productions, and ... using the click of a mouse. Manipulate camera controls to make beautiful and unique ...
Breaking Medicine News(10 mins):
(Date:6/30/2017)... June 30, 2017  AVACEN Medical (AVACEN) announced the publication of ... describes the use of its AVACEN Treatment Method to ... fibromyalgia. ... AVACEN Medical ... chronic widespread pain. It affects approximately 200 to 400 million people worldwide ...
(Date:6/27/2017)...  Therapix Biosciences Ltd. (Nasdaq: TRPX ) ... development of cannabinoid-based drugs, today announced that the Company ... New York, NY on Wednesday, ... offering (IPO) of American Depository Shares (ADSs) listed on ... Dr. Elran Haber, Ph.D., Chief Executive Officer of Therapix, ...
(Date:6/20/2017)... Netherlands and LAGUNA HILLS, Calif. ... the presentation of new data that validate the use ... risk stratify patients with multiple myeloma (MM). In a ... the European Hematology Association (EHA) in Madrid, ... value of MMprofiler for identifying high-risk elderly patients. ...
Breaking Medicine Technology: