Navigation Links
Decreased diversity of bacteria microbiome in the gut is associated with risk of colorectal cancer
Date:12/6/2013

Decreased diversity in the microbial community found in the human gut is associated with colorectal cancer, according to a new study published December 6 in the Journal of the National Cancer Institute.

Previous studies suggest a role for the gut microbiota in colorectal cancer (CRC), but comprehensive epidemiological studies comparing samples from case and control subjects that also consider potential confounders and adjust for multiple comparisons inherently involved in microbiome analysis have not been reported.

Jiyoung Ahn, Ph.D., from Department of Population Health at New York University School of Medicine in New York, NY, and colleagues compared samples and data from participants enrolled in a case-control study. DNA was extracted from fecal samples from 47 case subjects and 94 sex- and body mass index-matched control subjects and was sequenced to determine the gut microbial community structure of case vs control subjects. Odds ratios to determine the relationship between gut microbiota of case subjects vs control subjects were calculated using logistic regression analysis after adjusting for age, sex, BMI, race, smoking, and sequencing batch. They found decreased bacterial diversity in the gut was associated with CRC risk.

The authors highlight several trends in abundance of some key bacteria in the fecal samples they analyzed from case and control subjects that contribute to the decreased diversity associated with CRC risk which they report. Case subjects showed decreased levels of Clostridia, which include some bacterial family members that ferment dietary fiber, to butyrate, which is a major colonic metabolite that may inhibit inflammation and carcinogenesis in the colon. Also of note, increased levels of Fusobacterium and Porphyromonas, bacteria related to inflammation in in the mouth and gastrointestinal track was observed for case vs control subjects.

The authors write, "Because of the potentially modifiable nature of the gut bacteria, our findings may have implications for CRC prevention."

In an accompanying editorial, Volker Mai, Ph.D., M.P.H., and J. Glenn Morris, Jr., M.D., M.P.H., T.M. from the University of Florida at Gainesville FL, say the findings by Ahn et al. are exciting. However, they also write, "CRC occurrence is known to be influenced by host genetics, as well as factors such as obesity, nutrition and exercise; given that these factors also influence microbiota, separation of cause and effect among all of these factors may become quite difficult." Mai and Morris conclude that prospective cohort studies are therefore warranted.


'/>"/>

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Aging process accompanied by decreased hippocampal synaptophysin
2. Due the Recent Improvement in the Professionals' Database, FreelanceCoach Bounce Rate Has Been Decreased by 42%!
3. New optical metrics can identify patients on fast track to decreased vision
4. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offer Improved hCG Diet Plans Capable of Targeting Stubborn Belly Fat Now Linked With Decreased Bone Density
5. Risk of death has decreased for children initially treated with dialysis for ESKD
6. Women's Excellence in Menopause Now Offering Treatment Options for Decreased Sex Drive near Rochester Hills, Michigan; Natural Therapy Available via Bioidentical Hormones
7. New Solutions for Hot Flashes, Night Sweats, and Decreased Sex Drive Available Now at Women's Excellence in Menopause, Affiliated with Crittenton Hospital Center
8. Survey of clinicians: User satisfaction with electronic health records has decreased since 2010
9. Overdose education, bystander nasal naloxone rescue kits associated with decreased opioid overdose death
10. Limiting neurosurgery residents work hours hasnt decreased complication rates
11. Decreased kidney function leads to decreased cognitive functioning
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... 2017 , ... "The Better Care Reconciliation Act (BCRA) falls ... people with all chronic conditions, including mental illnesses, while increasing the cost of ... Care Act (ACA) requirement that insurers cover pre-existing conditions, it does not require ...
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that carotenoids and antioxidants derived ... loss in these patients. , But how often do ophthalmologists and optometrists in Sweden ... at risk of or with early symptoms of AMD? A study published recently ...
(Date:6/23/2017)... ... 23, 2017 , ... Military Connection friend and veteran advocate Micaela ... Virgin Atlantic lounge. , Bensko is no stranger to the plight of the ... her life to supporting our wounded veterans. A world-class photographer, her riveting photos “The ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Aesthetic Channel has ... Dr. Talei has come up with a proprietary technique that he calls the ... that have dropped. For all ages, patients can expect to look refreshed, rejuvenated, and ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... 21 Middle ... (EF) has selected 21 leaders from government, business and civil society in 11 ... in the U.S. this fall, engaging in a transformative exchange of knowledge and ideas ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... BOSTON , June 16, 2017  Exactly 50 years ... kicked off what later became known as the San Francisco ... www.northernlight.com ) is unveiling two radical innovations in strategic market ... summer.  This announcement marks the beginning of Northern Light,s "Summer ... ...
(Date:6/14/2017)... , June 14, 2017 The Bio ... City of Fremont and the ... the bio-pharma industry in California ... enabling executive networking, and fostering workforce development. The primary ... and growth of start-ups, as well as small and ...
(Date:6/13/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), a ... Food and Drug Administration (FDA) has notified the Company that ... Zhejiang, China manufacturing facility has been ... clearance of the Warning Letter related to our ... of the progress we have made in our ongoing quality ...
Breaking Medicine Technology: