Navigation Links
Decreased activity of basal ganglia is the main cause of abnormal muscle constrictions in dystonia

Dystonia is a neurological disorder characterized by involuntary abnormal muscle constrictions. More than 300,000 people in North America are affected, but the mechanism of abnormal muscle constrictions has not been well understood. Here, Japanese research team led by Prof Atsushi Nambu and Dr Satomi Chiken of National Institute for Physiological Sciences (NIPS) in Japan, with Dr. Pullanipally Shashidharan of Mt Sinai School of Medicine in USA, has found that the decreased activity of the basal ganglia, a part of the brain structure, is the main cause of abnormal muscle constrictions of dystonia using a mouse model. They report their findings in Journal of Neuroscience, on Dec 17, 2008.

They investigated neuronal activity in the basal ganglia of a dystonia mouse model, which was generated by transferring human dystonia genes, in awake state. Basal ganglia send inhibitory signals to the motor cortex and tune optimal movement in normal state. However, in the dystonia mouse model, the neuronal activity is decreased so that basal ganglia cannot inhibit motor cortical activity related to unnecessary movements. The research team has concluded that this is the main cause of involuntary abnormal muscle constrictions in dystonia patients.

"Now we understand the mechanism of abnormal muscle constrictions in dystonia. If we can artificially increase basal ganglia activity, abnormal muscle constrictions in dystonia patients could be well controlled", said Prof Nambu and Dr Chiken.


Contact: Prof. Atsushi Nambu
National Institute for Physiological Sciences

Page: 1

Related medicine news :

1. Dieticians & Nutritionists Report Decreased Confidence in Food Supply
2. Obesity linked to decreased seatbelt use
3. Acute coronary events decreased after public smoking ban in Italy
4. Men who are continually active at work may have a decreased risk of prostate cancer
5. Decreased sexual satisfaction is not associated with cardiovascular disease in postmenopausal women
6. Raloxifene Safe for Women With Decreased Kidney Function
7. Decreased total sleep time associated with increased REM sleep during subsequent naps
8. Number of Uninsured Decreased in 2007 But Census Report Shows Growing Health Coverage Problems
9. Vision restoration therapy shown to improve brain activity in brain injured patients
10. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
11. Food Additives Could Fuel Hyperactivity in Kids
Post Your Comments:
(Date:12/1/2015)... ... , ... With FCPX Overlay: Grit , users can apply a grit ... are truly endless, all with a click of a mouse. Each user has full ... depth of field and more, all within Final Cut Pro X. , With FCPX ...
(Date:12/1/2015)... ... December 01, 2015 , ... SonaCare Medical ... HSJ Acute Sector Innovation Award on November 18th. This prestigious award recognizes annually ... propose exciting enhancements to the medical landscape. , The UCLH team won the ...
(Date:11/30/2015)... ... 2015 , ... Olympic Gold Medalists and Celebrity Moms Dara ... various categories through traditional and social media marketing campaigns and other branding initiatives. ... Medal Moms who can connect with today’s most important consumer: mothers. In addition ...
(Date:11/30/2015)... City, NY (PRWEB) , ... December 01, 2015 ... ... honors Christina Colon as a 2015-2016 inductee into its VIP ... leadership in pharmacy. NAPW is the nation’s leading networking organization exclusively for professional ...
(Date:11/30/2015)... ... 30, 2015 , ... 1Heart Caregiver Services’ Executive Team actively ... Philippine American Chambers of Commerce held from November 6-8, 2015 at the Monte ... as an active delegate from the Philippine American Chamber of Commerce of Greater ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015   Royal Philips  (NYSE: ... of Radiology Solutions, a fully integrated, consultative approach ... customized, data-driven practice management approaches that combine imaging ... practices improve care delivery and reduce costs. Making ... of North America Annual Meeting (RSNA) in ...
(Date:11/30/2015)... 30, 2015 Nautilus Medical Inc. today announced ... platform ( ). The release of MatrixRay to ... 2015 (Radiology Society North America) in Chicago ... U.S. --> --> ... access to radiology studies worldwide via a peer-to-peer exchange ...
(Date:11/30/2015)... 30, 2015 (HK$,000)For the Six Months Ended 30 September 2015 2014RestatedChange%Turnover 545,575 ... , 421,979 , 384,242 , ... 34,719 , (18.3) Medical Insurance Administration Service ... 16.1 Medical Devices and Accessories Sales , 89,645 ... Herbal Medicines Sales , 2,822 , 2,917 ...
Breaking Medicine Technology: