Navigation Links
Decreased activity of basal ganglia is the main cause of abnormal muscle constrictions in dystonia
Date:12/17/2008

Dystonia is a neurological disorder characterized by involuntary abnormal muscle constrictions. More than 300,000 people in North America are affected, but the mechanism of abnormal muscle constrictions has not been well understood. Here, Japanese research team led by Prof Atsushi Nambu and Dr Satomi Chiken of National Institute for Physiological Sciences (NIPS) in Japan, with Dr. Pullanipally Shashidharan of Mt Sinai School of Medicine in USA, has found that the decreased activity of the basal ganglia, a part of the brain structure, is the main cause of abnormal muscle constrictions of dystonia using a mouse model. They report their findings in Journal of Neuroscience, on Dec 17, 2008.

They investigated neuronal activity in the basal ganglia of a dystonia mouse model, which was generated by transferring human dystonia genes, in awake state. Basal ganglia send inhibitory signals to the motor cortex and tune optimal movement in normal state. However, in the dystonia mouse model, the neuronal activity is decreased so that basal ganglia cannot inhibit motor cortical activity related to unnecessary movements. The research team has concluded that this is the main cause of involuntary abnormal muscle constrictions in dystonia patients.

"Now we understand the mechanism of abnormal muscle constrictions in dystonia. If we can artificially increase basal ganglia activity, abnormal muscle constrictions in dystonia patients could be well controlled", said Prof Nambu and Dr Chiken.


'/>"/>

Contact: Prof. Atsushi Nambu
nambu@nips.ac.jp
81-564-557-771
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1

Related medicine news :

1. Dieticians & Nutritionists Report Decreased Confidence in Food Supply
2. Obesity linked to decreased seatbelt use
3. Acute coronary events decreased after public smoking ban in Italy
4. Men who are continually active at work may have a decreased risk of prostate cancer
5. Decreased sexual satisfaction is not associated with cardiovascular disease in postmenopausal women
6. Raloxifene Safe for Women With Decreased Kidney Function
7. Decreased total sleep time associated with increased REM sleep during subsequent naps
8. Number of Uninsured Decreased in 2007 But Census Report Shows Growing Health Coverage Problems
9. Vision restoration therapy shown to improve brain activity in brain injured patients
10. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
11. Food Additives Could Fuel Hyperactivity in Kids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2017)... ... ... Six greater Bay Area roller derby leagues are partnering with Brown Paper Tickets and the ... of blood drives in California, beginning July 29. Make ‘Em Bleed roller derby blood drives ... to have helped to save up to 2700 lives. , “The Make ‘Em Bleed blood ...
(Date:7/26/2017)... ... July 26, 2017 , ... ... (ISPE) will host its 2017 Process Validation and Process Validation Statistics ... comprehensive solutions to process validation lifecycle challenges faced by process validation professionals ...
(Date:7/26/2017)... ... July 26, 2017 , ... A global ... in Jupiter. The state of the art center will provide advanced surgical ... a goal of providing heart patients longer lives. , North American Veterinary Heart ...
(Date:7/26/2017)... , ... July 26, 2017 , ... ... innovative specialty pharmacies, has released an updated version of the HCV Treatment Path ... for treating chronic hepatitis C virus (HCV) infection. All of the latest HCV ...
(Date:7/25/2017)... (PRWEB) , ... July 25, 2017 , ... ... to announce the launch of their partnership to provide the Pharmacist eCare ... first pharmacy-focused platform in the country with the ability to develop the Pharmacist ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... EDMONTON, Alberta , July 21, 2017 ... the University of Alberta in Edmonton, ... Nature,s partner journal, Schizophrenia 1 , demonstrating that ... of schizophrenia with 74% accuracy. This retrospective analysis ... specific symptoms in schizophrenia patients with significant correlation, ...
(Date:7/20/2017)... PAUL, Minn. , July 20, 2017  Prime Therapeutics ... Jonathan Gavras , M.D., following today,s Institute for Clinical ... report on the effectiveness and value of abuse-deterrent ... manager on the policy roundtable at the meeting. ... is not a material cost benefit to the use of ...
(Date:7/14/2017)... , July 14, 2017 Endo International plc (NASDAQ: ... Tuesday, August 8, 2017.  Members of its senior management team will ... open at 8:30 a.m. ET. The dial-in number ... 497-0462, International (678) 509-7598, and the passcode is 45397076. Please dial ... A replay of the call will ...
Breaking Medicine Technology: