Navigation Links
Decrease in sense of smell seen in lupus patients
Date:4/30/2009

The sense of smell is a complex process of the central nervous system that involves specific areas of the brain. In fact, olfactory dysfunction is seen in various central nervous system disorders that involve immune-mediated mechanisms, such as Parkinson's disease, schizophrenia, Alzheimer's disease and multiple sclerosis. Systemic lupus erythematosus (SLE) is an autoimmune disease that sometimes involves the central nervous system in a condition known as neuropsychiatric SLE (NPSLE). Research in mice has shown that NPSLE-like symptoms and olfactory impairment might be induced by autoimmune mechanisms that target specific areas of the brain, but this has not been explored. A new study assessed olfactory function in SLE patients and found that there is a decrease in the sense of smell compared with healthy controls. The study was published in the May issue of Arthritis & Rheumatism (http://www3.interscience.wiley.com/journal/76509746/home).

Led by Yehuda Shoenfeld of Chaim Sheba Medical Center in Tel-Hashomer, Israel, the study involved 50 SLE patients and 50 age and sex-matched controls. Researchers evaluated three levels of olfactory function: threshold (identifying a stick with an odor from among sticks that didn't have an odor); discrimination (differentiating between two smells); and identification of a smell from among four options. The three scores were combined to form a total TDI score.

The results showed significant olfactory deficits in the SLE patients compared with the controls. SLE patients showed a decrease in olfactory function in both the threshold and discrimination tests. In addition, the study found that patients with more active disease and past NPSLE manifestations had significantly lower TDI scores. Past research in mice has shown that injection of antibodies linked to NPSLE manifestations induced olfactory deficit and that these antibodies can bind and penetrate cells in limbic areas of the brain, which are associated with the sense of smell. In addition, magnetic resonance imaging has recently shown limbic system involvement in SLE patients. "Although the exact mechanism of olfactory impairment has yet to be elucidated, the possibility of an immune-mediated mechanism is intriguing," the authors note.

The incidence of olfactory dysfunction in the general population is a matter of debate. About one percent of the population is believed to have a loss of the sense of smell; in the study, loss of smell was seen only in SLE patients, 10 percent of whom suffered from this condition. The importance of the sense of smell is easy to appreciate, since the inability to detect odors in daily life, for example in food that has spoiled or leaks in a gas line, could seriously compromise a person's health.

The authors point out that olfaction is unfamiliar territory for rheumatologists and immunologists, but results from this and other studies demonstrate that an autoimmune mechanism may play a role in olfactory impairment. They conclude that "smell decrement has been found to be an early and predictive sign in several CNS diseases, and therefore, might be a useful and easy tool for the physician in early diagnosis of CNS involvement in autoimmune diseases."


'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Amgens First Quarter 2009 Adjusted Earnings Per Share Decreased 4 Percent to $1.08
2. Excluding the lateral view in chest radiograph screenings decreases radiation exposure by 67 percent
3. Treating HIV earlier to decrease the risk of death
4. Omega-3 EPA/DHA May Decrease Risk of Developing Prostate Cancer
5. Some radiation therapy treatments can decrease fertility
6. Universal vaccination associated with decreased Canadian cases of most deadly strain of meningitis
7. Device aims to decrease wait period for patients needing immunotherapy
8. Seniors in Medicares doughnut hole decrease use of meds
9. Mammography utilization in the United States decreases: A state-level look
10. Controversial medication may decrease spasms for infants with epilepsy
11. Risk takers, drug abusers driven by decreased ability to process dopamine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology: