Navigation Links
Decrease in sense of smell seen in lupus patients
Date:4/30/2009

The sense of smell is a complex process of the central nervous system that involves specific areas of the brain. In fact, olfactory dysfunction is seen in various central nervous system disorders that involve immune-mediated mechanisms, such as Parkinson's disease, schizophrenia, Alzheimer's disease and multiple sclerosis. Systemic lupus erythematosus (SLE) is an autoimmune disease that sometimes involves the central nervous system in a condition known as neuropsychiatric SLE (NPSLE). Research in mice has shown that NPSLE-like symptoms and olfactory impairment might be induced by autoimmune mechanisms that target specific areas of the brain, but this has not been explored. A new study assessed olfactory function in SLE patients and found that there is a decrease in the sense of smell compared with healthy controls. The study was published in the May issue of Arthritis & Rheumatism (http://www3.interscience.wiley.com/journal/76509746/home).

Led by Yehuda Shoenfeld of Chaim Sheba Medical Center in Tel-Hashomer, Israel, the study involved 50 SLE patients and 50 age and sex-matched controls. Researchers evaluated three levels of olfactory function: threshold (identifying a stick with an odor from among sticks that didn't have an odor); discrimination (differentiating between two smells); and identification of a smell from among four options. The three scores were combined to form a total TDI score.

The results showed significant olfactory deficits in the SLE patients compared with the controls. SLE patients showed a decrease in olfactory function in both the threshold and discrimination tests. In addition, the study found that patients with more active disease and past NPSLE manifestations had significantly lower TDI scores. Past research in mice has shown that injection of antibodies linked to NPSLE manifestations induced olfactory deficit and that these antibodies can bind and penetrate cells in limbic areas of the brain, which are associated with the sense of smell. In addition, magnetic resonance imaging has recently shown limbic system involvement in SLE patients. "Although the exact mechanism of olfactory impairment has yet to be elucidated, the possibility of an immune-mediated mechanism is intriguing," the authors note.

The incidence of olfactory dysfunction in the general population is a matter of debate. About one percent of the population is believed to have a loss of the sense of smell; in the study, loss of smell was seen only in SLE patients, 10 percent of whom suffered from this condition. The importance of the sense of smell is easy to appreciate, since the inability to detect odors in daily life, for example in food that has spoiled or leaks in a gas line, could seriously compromise a person's health.

The authors point out that olfaction is unfamiliar territory for rheumatologists and immunologists, but results from this and other studies demonstrate that an autoimmune mechanism may play a role in olfactory impairment. They conclude that "smell decrement has been found to be an early and predictive sign in several CNS diseases, and therefore, might be a useful and easy tool for the physician in early diagnosis of CNS involvement in autoimmune diseases."


'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Amgens First Quarter 2009 Adjusted Earnings Per Share Decreased 4 Percent to $1.08
2. Excluding the lateral view in chest radiograph screenings decreases radiation exposure by 67 percent
3. Treating HIV earlier to decrease the risk of death
4. Omega-3 EPA/DHA May Decrease Risk of Developing Prostate Cancer
5. Some radiation therapy treatments can decrease fertility
6. Universal vaccination associated with decreased Canadian cases of most deadly strain of meningitis
7. Device aims to decrease wait period for patients needing immunotherapy
8. Seniors in Medicares doughnut hole decrease use of meds
9. Mammography utilization in the United States decreases: A state-level look
10. Controversial medication may decrease spasms for infants with epilepsy
11. Risk takers, drug abusers driven by decreased ability to process dopamine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... 2017 , ... Judy Buchanan, co-owner of Serenity Natural Health ... says, “I am passionate about sharing Reiki as a holistic, complementary therapy with ... time.” , A Certified Medical Reiki™ Master trained by Raven Keys Medical Reiki™ ...
(Date:3/24/2017)... ... ... “End Time GPS”: a dauntless and enlightened study of the second-coming of Christ, ... of published author, Wesley Gerboth, a World War II veteran, with a highly-regarded reputation ... age ninety-one, he shares the Wisdom God bestowed upon him in this publication. ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... stories about real people of God in congregations across the United States. ... Presbyterian minister ordained in 1964 who has served congregations in seven states throughout ...
(Date:3/23/2017)... Greensboro, NC & Seattle, WA (PRWEB) , ... March 23, 2017 ... ... international public health emergency and now estimates that there could be four million Zika-related ... fastest growing epidemics to date with numbers of US cases reported per year skyrocketing ...
(Date:3/23/2017)... ... March 23, 2017 , ... The physicians of KSF ... the greater Houston Area. The new location is located at 2255 E. Mossy Oaks ... Springwoods Village. This newest location will provide patients living in the north Houston area ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Research and Markets has announced the addition of the ... 2022" report to their offering. ... The global wound care market was worth $24,482.9 million in ... during 2016-2022 Among the various wound care products type, the ... market in 2015. Among the various applications, surgical wound segment held the ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Dental ... ... markets for Dental Implants in US$ Million. The report provides separate comprehensive ... , Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period 2015 through ...
(Date:3/24/2017)... 24, 2017 ShangPharma, a leading ... cost-effective drug development and discovery services, technology, ... industry, announced today the intent for a ... be consolidating the Contract Research Organizations (CRO) ... ChemPartner. These entities include ChemPartner Shanghai, ChemPartner ...
Breaking Medicine Technology: