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Decoding Muscle Stem Cell Development
Date:5/12/2008

ble conditions. On the other hand, once nutrients become available, the pathway is inactivated to allow resumption of physiological development," researcher Vittorio Sartorelli said in a prepared statement.

This same mechanism also operates in adult tissues, which means it would be part of the response to a diet with reduced calorie intake. The researchers also found that both glucose restriction or treatment of skeletal muscle cells with metformin (a drug used to treat type 2 diabetes) had similar outcomes and activated SIRT1.

"It is therefore possible that the well-known benefits that diabetics derive from lowering the calorie intake in their diet may be attributable to activation of the AMPK-Nampt-SIRT1 axis," Sartorelli said.

He added that AMPK and SIRT1 may prove good targets for treatment of muscle-wasting.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: Cell Press, news release, May 12, 2008


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