Navigation Links
Decoding Muscle Stem Cell Development
Date:5/12/2008

Nutrient restriction triggers pathway involved with life span, study finds

MONDAY, May 12 (HealthDay News) -- Muscle stem cells can't grow into mature muscle cells if there aren't enough nutrients, according to a study that offers new insight into how developing muscle cells sense and respond to nutrient levels.

The research, part of ongoing investigations into the effects of caloric restriction on physiology and aging, may help in the development of new treatments for muscle wasting.

In this study, National Institutes of Health researchers examined how the availability of glucose affects the ability of muscle stem cells (myoblasts) to develop into mature skeletal muscle fibers.

According to a news release about the study, the researchers "found that glucose restriction (GR) impaired differentiation of skeletal myoblasts and activated AMP-activated protein kinase (AMPK). These results define a pathway in which activation of AMPK in response to low glucose levels stimulates expression of the NAD+ biosynthetic enzyme Nampt. NAD+ is a known co-factor of SIRT1, which plays an important role in numerous physiological processes, including differentiation of skeletal muscle cells, and has been implicated in regulation of life span and aging. Importantly, inhibition of AMPK, Nampt or SIRT1 resulted in skeletal muscle cells that were oblivious to a nutrient-poor environment and were able to differentiate under conditions that otherwise would not be suitable."

The researchers said their findings, published in the May issue of Developmental Cell, show that a specific pathway controls muscle cell differentiation in response to low nutrient levels.

"We speculate that, functioning as a cellular checkpoint, the AMPK-Nampt-SIRT1 pathway may be activated by reduced nutrient availability to prevent cells from undertaking energy-demanding processes -- such as cell differentiation -- during calorie-unfavorable conditions. On the other hand, once nutrients become available, the pathway is inactivated to allow resumption of physiological development," researcher Vittorio Sartorelli said in a prepared statement.

This same mechanism also operates in adult tissues, which means it would be part of the response to a diet with reduced calorie intake. The researchers also found that both glucose restriction or treatment of skeletal muscle cells with metformin (a drug used to treat type 2 diabetes) had similar outcomes and activated SIRT1.

"It is therefore possible that the well-known benefits that diabetics derive from lowering the calorie intake in their diet may be attributable to activation of the AMPK-Nampt-SIRT1 axis," Sartorelli said.

He added that AMPK and SIRT1 may prove good targets for treatment of muscle-wasting.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: Cell Press, news release, May 12, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. UT Health Science Center researchers decoding saliva to detect breast cancer
2. Stanford researchers find culprit in aging muscles that heal poorly
3. New treatment boosts muscle function in myasthenia gravis
4. New Drug Aids Muscle Function in Myasthenia Gravis
5. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
6. Muscle patterns in women may be linked to at risk positioning for ACL tears
7. Endoscopic resection is a safe and effective treatment for gastrointestinal smooth muscle tumors
8. Study reveals how stem cells decide to become either skeletal or smooth muscle
9. Pre-Workout Stretching Wont Prevent Sore Muscles
10. Steroids Are Abused for Skin, Not Just Muscles
11. AUA releases new guidelines on non-muscle invasive bladder cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 24, 2017 , ... Element ... products, today announced a strategic partnership with Lucidworks , the company transforming ... analyze their Fusion platform for building powerful enterprise search applications. , Element Blue ...
(Date:1/24/2017)... ... January 24, 2017 , ... Manzo Pharmaceuticals, LLC., announced ... Registered Trademark by the United States Patent and Trademark Office. The purpose ... confuse consumers into thinking that other products are similar to the patented Lacto-Freedom ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... the semi-final round of the 2017 Cupid's Cup Entrepreneurship Competition. Chaired by Under ... year in 2017. The entrepreneurs will showcase their businesses on February 6, 2017, ...
(Date:1/24/2017)... LONG GROVE, ILL. (PRWEB) , ... January 24, ... ... natural odor abatement solutions, announced that it has officially formed a distribution partnership ... of equipment for the industrial odor management industry. , Through the agreement, OMI ...
(Date:1/24/2017)... , ... January 24, 2017 , ... Center for ... century leadership, has named Hector M. Chavez, Manager, Employee & Labor Relations at ... - as its Hispanic Leader of the Month. City of Hope is committed to ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... LYNBROOK, N.Y. , Jan. 24, 2017 ... BSTC ), a biopharmaceutical company that originated ... a first in class collagenase-based product collagenase ... ┬«  in the U.S. and Xiapex ┬« ... will present a corporate overview at the ...
(Date:1/24/2017)... JOLLA, Calif. , Jan. 24, 2017 ... new case studies using its Biomedical Intelligence® Cloud - ... knowledge from a multitude of genomic, molecular and clinical ... updates were presented at a session hosted by Data4Cure ... Mountain View, CA. The ...
(Date:1/24/2017)... Jan. 24, 2017 Trifecta Clinical , ... is appointing Rick Ward to Vice President ... Trifecta is also announcing the promotion of Ericka ... Rick joins Trifecta from Greenphire where ... held senior business development positions within the healthcare industry ...
Breaking Medicine Technology: