Navigation Links
Decoding Muscle Stem Cell Development
Date:5/12/2008

Nutrient restriction triggers pathway involved with life span, study finds

MONDAY, May 12 (HealthDay News) -- Muscle stem cells can't grow into mature muscle cells if there aren't enough nutrients, according to a study that offers new insight into how developing muscle cells sense and respond to nutrient levels.

The research, part of ongoing investigations into the effects of caloric restriction on physiology and aging, may help in the development of new treatments for muscle wasting.

In this study, National Institutes of Health researchers examined how the availability of glucose affects the ability of muscle stem cells (myoblasts) to develop into mature skeletal muscle fibers.

According to a news release about the study, the researchers "found that glucose restriction (GR) impaired differentiation of skeletal myoblasts and activated AMP-activated protein kinase (AMPK). These results define a pathway in which activation of AMPK in response to low glucose levels stimulates expression of the NAD+ biosynthetic enzyme Nampt. NAD+ is a known co-factor of SIRT1, which plays an important role in numerous physiological processes, including differentiation of skeletal muscle cells, and has been implicated in regulation of life span and aging. Importantly, inhibition of AMPK, Nampt or SIRT1 resulted in skeletal muscle cells that were oblivious to a nutrient-poor environment and were able to differentiate under conditions that otherwise would not be suitable."

The researchers said their findings, published in the May issue of Developmental Cell, show that a specific pathway controls muscle cell differentiation in response to low nutrient levels.

"We speculate that, functioning as a cellular checkpoint, the AMPK-Nampt-SIRT1 pathway may be activated by reduced nutrient availability to prevent cells from undertaking energy-demanding processes -- such as cell differentiation -- during calorie-unfavorable conditions. On the other hand, once nutrients become available, the pathway is inactivated to allow resumption of physiological development," researcher Vittorio Sartorelli said in a prepared statement.

This same mechanism also operates in adult tissues, which means it would be part of the response to a diet with reduced calorie intake. The researchers also found that both glucose restriction or treatment of skeletal muscle cells with metformin (a drug used to treat type 2 diabetes) had similar outcomes and activated SIRT1.

"It is therefore possible that the well-known benefits that diabetics derive from lowering the calorie intake in their diet may be attributable to activation of the AMPK-Nampt-SIRT1 axis," Sartorelli said.

He added that AMPK and SIRT1 may prove good targets for treatment of muscle-wasting.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: Cell Press, news release, May 12, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. UT Health Science Center researchers decoding saliva to detect breast cancer
2. Stanford researchers find culprit in aging muscles that heal poorly
3. New treatment boosts muscle function in myasthenia gravis
4. New Drug Aids Muscle Function in Myasthenia Gravis
5. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
6. Muscle patterns in women may be linked to at risk positioning for ACL tears
7. Endoscopic resection is a safe and effective treatment for gastrointestinal smooth muscle tumors
8. Study reveals how stem cells decide to become either skeletal or smooth muscle
9. Pre-Workout Stretching Wont Prevent Sore Muscles
10. Steroids Are Abused for Skin, Not Just Muscles
11. AUA releases new guidelines on non-muscle invasive bladder cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, ... work on several important health care topics including advance care planning, healthcare costs ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dublin - ... " Global Markets for Spectroscopy Equipment" report ... This report focuses on the global market of ... applications in various applications. The report deals with spectroscopy ... industries: pharmaceutical and biotechnology, food and beverage, and environmental ...
(Date:6/24/2016)... Mass. and SAN CLEMENTE, Calif. , ... California -based mobile pulmonary function testing company, is now able ... PFT devices developed by ndd Medical Technologies , Inc. ... testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® ... , can get any needed testing done in the comfort ...
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
Breaking Medicine Technology: