Navigation Links
Decoded: Molecular messages that tell prostate and breast cancers to spread
Date:4/30/2013

ANN ARBORCancer cells are wily, well-traveled adversaries, constantly side-stepping treatments to stop their spread. But for the first time, scientists at the University of Michigan have decoded the molecular chatter that ramps certain cancer cells into overdrive and can cause tumors to metastasize throughout the body.

Researchers have long known that tumors recruit healing cells, which is a major reason why cancer is so difficult to thwart. This is the first known study to explain the molecular behavior behind the series of changes that happen in the healing cells that result in metastasis.

Russell Taichman, a professor at the U-M School of Dentistry and research associate Younghun Jung looked at prostate and breast tumors. Their study, "Recruitment of mesenchymal stem cells into prostate tumors promotes metastasis," appears April 30 in the online journal Nature Communications.

Consider that a tumor is a wound that won't heal. To that end, both cancerous and benign tumors emit distress signals and messages to recruit healing-type cells, called mesenchymal stem cells, or MSCs, Taichman said.

"Now we know what messages (tumors) send to recruit and alter those healing cells, and we can take steps to block those messages," said Taichman, the study's principal investigator.

With this information, researchers can now try to develop drugs to pharmaceutically derail tumor formation earlier. This is especially important because this particular molecular signaling involves reactions among proteins that actually make cancer cells more migratory, more aggressive and more likely to spread.

To that end, Taichman said he was surprised at the large role played by the protein CXCL16 in altering the healing type cells in such a way that they revved the cancer cells into overdrive.

"Think of giving a bunch of kids sugar, and they all go nuts," he said.

On a personal level, the way the results emerged also delighted Taichman. Half of the researchers in Taichman's lab work on tumor development and half on wound healing. The research of Jung, the first author on the study, straddles both.

"It was her idea to put these together," Taichman said. "She sorted it all out, came up with the idea and finally came to me."


'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan
Source:Eurekalert

Related medicine news :

1. Improved molecular tools streamline influenza testing and management
2. A molecular superglue based on flesh-eating bacteria
3. Tsai wins innovator award for plan to map molecular path to skin cancer
4. Advances in molecular testing offer new hope for lung cancer patients
5. Scientists identify brains molecular memory switch
6. Study finds molecular signature for rapidly increasing form of esophageal cancer
7. Flip of a single molecular switch makes an old brain young
8. Molecular coordination in evolution: A review in Nature Reviews Genetics
9. Obesity, physical inactivity linked with risk for certain molecular subtype of colorectal cancer
10. UNC-led study documents head and neck cancer molecular tumor subtypes
11. Molecular master switch for pancreatic cancer identified, potential predictor of treatment outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... On May 23rd during the National ... Science® and international water advocate, was honored by Ashram, Inc. as the world’s foremost ... who knelt on the banks of the Nile to fill their red clay pots ...
(Date:5/26/2016)... ... May 26, 2016 , ... Saint Francis ... several years, and the efforts have paid off. Since implementation of these ... of care to enhance perioperative patient experiences and reduce costly complications. Since implementation ...
(Date:5/26/2016)... Viejo, California (PRWEB) , ... May 26, 2016 , ... ... Transition Plugin for FCPX. , "This new layered style transition tool will ... said Christina Austion - CEO of Pixel Film Studios. , TranSweep is an ...
(Date:5/26/2016)... ... May 26, 2016 , ... TopConsumerReviews.com recently awarded their ... . , High blood pressure affects millions of people worldwide, and many patients ... lead to heart disease, stroke, kidney disease, and hardening of the arteries. However, ...
(Date:5/25/2016)... ... , ... The United States Food and Drug Administration (FDA) has now cleared ... To date, the company is the first and only manufacturer of low level laser ... androgenetic alopecia. , “This new level of clearance substantiates what many physicians have ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 ... de doble terapia del mundo, introduce catéteres para ... OrbusNeich, una compañía global especializada en ... vidas, ha expandido su cartera incluyendo productos para ... JADE™ y Scoreflex™ PTA son los dispositivos de ...
(Date:5/24/2016)... 2016 Een app die artsen ... collectief patiënten kunnen behandelen, hun kennis kunnen delen en ... de nieuwe en revolutionaire MDLinking App, ontwikkeld door een ... dr. Hans Flu en oncologisch chirurg dr. Gijs ... is, wordt op dinsdag 24 mei officieel gepresenteerd op ...
(Date:5/23/2016)... ALBANY, New York , May 23, 2016 /PRNewswire/ ... new market report titled, " Exocrine Pancreatic Insufficiency Market ... Forecast 2013 - 2023 ." According to the report, ... at a CAGR of 8.3% from 2015 to 2023 ... pancreatic insufficiency (EPI) is a condition characterized by the ...
Breaking Medicine Technology: