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Decline in available liver transplants expected
Date:1/10/2013

ccurred after June 30, 2004 with 82% of livers used for transplant and 18% unused. The number of unused livers decreased from 1,958 (66% of donors) in 1988 to 841 (15%) in 2004, and then increased to 1,345 (21%) in 2010. Liver non-use was independently linked to older donor age, greater BMI, diabetes prevalence and donation after cardiac deathall of which are on the rise in the U.S.

Researchers reported a four-fold increase in the odds of non-use of livers from donation following cardiac death donors between 2004 and 2010, with the proportion of nonuse climbing from 9% to 28% during the same time period. "Our findings show nonuse of livers for transplantation is steadily rising, and is primarily due to donation after cardiac death," concludes Dr. Orman. "If these trends continue, a significant decline in liver transplant availability would be inevitable."

In a related editorial also published in Liver Transplantation, Dr. Anton Skaro from the Feinberg School of Medicine at Northwestern University in Chicago, Ill. concurs, "Utilization of livers donated after cardiac death increases risk of biliary complications, greater costs and higher graft failure rates, resulting in a reduction of liver transplants using organs donated after cardiac death in the U.S. since 2006." Dr. Skaro suggests that liver transplantation using organs donated after cardiac death should be encouraged for recipients who would have poor outcomes by remaining on the waitlist.


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Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

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