Navigation Links
Decline in available liver transplants expected
Date:1/10/2013

A new study, funded in part by the National Institutes of Health (NIH) and Health Resources and Services Administration, and published in the January 2013 issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases (AASLD), found that the non-use of donor livers climbed through 2010 due to a worsening of donor liver quality, primarily from donation following cardiac death. Diabetes, donor age, and body mass index (BMI) were also linked to a decrease in use of organs.

"For patients with end-stage liver disease, transplantation is the only option for extending life, but organ availability places constraints on the transplant community," explains Dr. Eric Orman with the University of North Carolina School of Medicine in Chapel Hill. "One of the methods to increase the donor pool is to include donors with less than ideal health statusthose with fatty livers, older donors, and donation after cardiac death."

In an attempt to increase available livers for transplant, the transplant community has gradually extended donation criteria. However, previous research shows that poor outcomes may occur following transplant of more inferior organs. In fact, studies have shown an increased recipient morbidity and mortality risk with donation after cardiac death (when circulation ceases) than with standard donation following brain death in which donor circulation is sustained.

For the present study researchers used data from the Organ Procurement and Transplantation Network (OPTN) to indentify 107,259 deceased donors in U.S. between 1988 and 2010. Donors were 18 years of age and older who had a least one organ (liver, heart, intestine, kidney, lung or pancreas) used for transplantation. The mean donor age was 44 years; 41% were female and 68% were white. Split liver donations and donors with BMI less than 14 kg/m2 or more than 50 kg/m2 were excluded.

Analysis indicates that 41,503 donations occurred after June 30, 2004 with 82% of livers used for transplant and 18% unused. The number of unused livers decreased from 1,958 (66% of donors) in 1988 to 841 (15%) in 2004, and then increased to 1,345 (21%) in 2010. Liver non-use was independently linked to older donor age, greater BMI, diabetes prevalence and donation after cardiac deathall of which are on the rise in the U.S.

Researchers reported a four-fold increase in the odds of non-use of livers from donation following cardiac death donors between 2004 and 2010, with the proportion of nonuse climbing from 9% to 28% during the same time period. "Our findings show nonuse of livers for transplantation is steadily rising, and is primarily due to donation after cardiac death," concludes Dr. Orman. "If these trends continue, a significant decline in liver transplant availability would be inevitable."

In a related editorial also published in Liver Transplantation, Dr. Anton Skaro from the Feinberg School of Medicine at Northwestern University in Chicago, Ill. concurs, "Utilization of livers donated after cardiac death increases risk of biliary complications, greater costs and higher graft failure rates, resulting in a reduction of liver transplants using organs donated after cardiac death in the U.S. since 2006." Dr. Skaro suggests that liver transplantation using organs donated after cardiac death should be encouraged for recipients who would have poor outcomes by remaining on the waitlist.


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Related medicine news :

1. US cancer death rates continue to decline, national report finds
2. US cancer screening rates decline over the last 10 years, finds new study
3. Less Mental Decline Seen in Older Blacks Who Went Hungry as Kids
4. Child Abuse in U.S. Declines for 5th Straight Year
5. Teen Fighting Declines in U.S., Europe
6. Kessler Foundation wins National MS Society grant to study prevention of cognitive decline
7. Researchers find decline in availability and use of key treatment for depression
8. Reduced Kidney Function Tied to Mental Decline
9. Owner of Meningitis-Linked Pharmacy Declines to Testify Before Congress
10. Pneumonia remains the leading killer of children despite decline in global child deaths
11. Many patients who die while awaiting liver transplant have had donor organs declined
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... February 24, 2017 , ... ... it is so critically important that we all are aware of our options ... Mediaplanet is proud to announce the launch of its newest edition of "Vision ...
(Date:2/24/2017)... ... February 24, 2017 , ... Yisrayl Hawkins, Pastor and ... Bible Prophecy concerning this present generation. Yisrayl makes an astounding statement when he ... He explains that the Bible details the current times so plainly that anyone ...
(Date:2/24/2017)... ... February 24, 2017 , ... Congratulations to Head ... division on February 12th. Ms. Esparza qualified into this prestigious status after ... held in Las Vegas, Nevada. Frida is one of approximately 25 gymnasts in ...
(Date:2/23/2017)... ... 2017 , ... The Lymphoma Research Foundation (LRF) – the ... the lymphoma community through a comprehensive series of education programs, outreach initiatives and ... Beach to host its Swirl: Miami Wine Tasting Event on March 28, 2017. ...
(Date:2/23/2017)... ... 23, 2017 , ... Rosica Communications, a national PR ... media management, corporate communications, SEO and cause marketing, is opening an office in ... Hampshire, Massachusetts and Canada, Rosica will focus on expanding its footprint. , ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Feb. 23, 2017 ITL Limited, ( ASX: ITD ), ... for the half year ended 31 December 2016 compared with the ... presentation can be viewed here . Highlights ... $1.04m; up 104%) Earnings per share of 2.2 ... of $17.5m (Dec 2015: $15.7m; up 11%) Profit ...
(Date:2/23/2017)... Research and Markets has announced the addition of the "Menopause ... ... Drugs Price Analysis and Strategies - 2016, provides drug pricing data and ... questions: What are the key drugs marketed ... Global Menopause market? What are the unit prices and ...
(Date:2/23/2017)... Research and Markets has announced the addition of the "Oesophageal ... their offering. ... The latest research Oesophageal Cancer Drugs Price Analysis and Strategies - ... Cancer market. The research answers the following questions: ... Oesophageal Cancer and their clinical attributes? How are they positioned in ...
Breaking Medicine Technology: