Navigation Links
Deciphering the body's healing secrets
Date:2/12/2009

Healthy blood vessels play a key role in the prevention and treatment of diseases such as cardiovascular disease and diabetes.

Endothelial cells line the blood vessels and are critical to the regulation of blood vessel growth and function.

Researchers at the Centenary Institute have discovered a mechanism that helps control the development of endothelial cells.

Professor Jenny Gamble, Head of the Vascular Biology program at Centenary, says the process by which endothelial progenitor cells (EPCs) change to mature endothelial cells is an important but little understood control.

"If endothelial cell lining is injured or damaged, for example during wound healing, an organ transplant or heart attack, the EPC leave the bone marrow, circulate in the blood and home to the site of the injury where they continue to repair and are induced to become mature cells," she explains.

Publishing in Blood, Professor Gamble and her team found that this process, called differentiation, is partly controlled by the enzyme sphingosine kinase-1.

"We found that high levels of SK-1 keep the cells as EPCs whereas a decrease in the amount of SK-1 allows the cell to differentiate to functionally mature endothelial cells."

By understanding these fundamental tools the body uses to heal itself, there is potential to manipulate this process to create new treatments.

For example, the vascular complications of diabetes are attributed, in part, to the decreased numbers and function of EPCs. Additionally, stents are used extensively for the treatment of cardiovascular disease. However they can often be problematic because of a lack of good endothelial cell coverage.

Centenary Institute Executive Director, Professor Mathew Vadas says an increased understanding of the process of differentiation may allow SK-1 to be manipulated to drive this process and therefore improve treatments of these diseases in the
'/>"/>

Contact: Erin Sharp
e.sharp@centenary.org.au
61-295-656-118
Research Australia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Deciphering the Language of Intoxication
2. Swelling After Knee Injury May Hinder Healing
3. Data from Patient Subsets of e-HEALING, a Worldwide Registry, Support Use of OrbusNeichs Genous(TM) Bio-Engineered R Stent(TM) as Alternative to Drug- Eluting Stents
4. Retired NYPD Lieutenants William E. Keegan, Jr., Owen McCaffery and John Moran and Tom Thees, a former COO in the financial industry, announce today the formation of H.E.A.R.T (Healing Emergency Aid Response Team) 911.
5. Cleveland Clinic Press Releases Journal-Writing Book Write for Life: Healing Body, Mind, and Spirit Through Journal Writing by Sheppard B. Kominars, Ph.D.
6. LOreal Paris Celebrates Ten Years of Hope and Healing
7. Newer Antibiotic Speeds TB Healing
8. The Well Life Center in Mesa Unveils The 10 Healing Secrets to Health & Longevity Lecture. Proceeds Benefit The Arizona Special Olympics
9. PEAK Surgical Announces Positive Surgical Incision Wound Healing Results With the PEAK PlasmaBlade(TM)
10. The Well Life Center in Mesa Continues The 10 Healing Secrets to Health & Longevity Lecture. Proceeds Benefit The Arizona Special Olympics
11. The Healing Power of Green
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2015)... May 30, 2015 At 73 years old, ... vibrant health , which she attributes to a lifetime ... of good nutrition with the release of her new book ... Xlibris AU). , “Cook for Health and Longevity” features a ... and mostly organic food . It is designed to ...
(Date:5/30/2015)... Cyclist Barry Haarde will commence his ... 2015: Piles of Miles” near San Francisco, California ... and encourage individuals to support needy hemophilic children ... Life supports nearly 1,200 impoverished children and adults ... sponsorships, scholarships and micro-enterprise grants. Hemophilia is a ...
(Date:5/30/2015)... 2015 San Luis Obispo insurance ... offering a free analysis and consultation for anyone interested ... Disability Awareness Month, which was created by the non-profit ... United States such as Polk recognize the proclamation, and ... the possibility of disability, as well as the often-overlooked ...
(Date:5/30/2015)... May 30, 2015 The iconic American ... will be hosting a new segment on Medical Malpractice. ... of medical malpractice in the health care field. , ... thousands of medical malpractice suits were filed, roughly only ... were settled out of court, while the remaining 30% ...
(Date:5/30/2015)... “ Milli the Snail ” was featured on NewsWatch as ... the latest and coolest applications on the market for iOS, ... technology expert, conducted the app review and shared with viewers ... children. , Interactive mobile games for children have become quite ... they are playing are doing much for their intellectual development. ...
Breaking Medicine News(10 mins):Health News:Lynn Kendall Shows How to ‘Cook for Health and Longevity’ 2Health News:Lynn Kendall Shows How to ‘Cook for Health and Longevity’ 3Health News:Barry Haarde Cycles 4,000 Miles Across the USA for Hemophilia 2Health News:San Luis Obispo Insurance Agent Susan Polk Offering Complementary Insurance Analysis In Honor Of Disability Awareness Month 2Health News:An Aesthetic Game that Engages and Educates Children was Featured on NewsWatch Television 2
... is one step in a long, slow process of reproductive ... age 40 and declining levels of the hormones estrogen and ... a female., ,Menopause, or the “change of life,” affects ... help women cope up better with menopause, hormone replacement therapy ...
... declared Tuberculosis as an emergency in Africa. It is ... WHO Regional // Committee for Africa comprising health ministers ... in the African region. The deaths have quadrupled in ... adopted today at the end of the Committee's fifty-fifth ...
... expression responsible for extreme farsightedness in people. , ... rare, potentially blinding disorder, is caused // by an ... eye growth and regulates the organ's shape and focus. ... the journal Proceedings of the National Academy of Sciences., ...
... probe for the treatment of brain cancer is the ... of Neurological Disorders at Manipal Hospital in Bangalore. // ... ,Removal of brain tumors surgically leads to enormous ... depends on the surgeon’s skill. By using the new ...
... a report published in the September issue of the ... programs that advocate quick and short working out sessions ... health conditions that can lead to diseases. To prevent ... and strenuous workout sessions are required every week. ...
... shown that use of general anesthesia for heroin detoxification ... detoxification. The study, which came in the latest issue ... // of general anesthesia in these circumstances can also ... heroin withdrawal remains plagued by patient discomfort and high ...
Cached Medicine News:Health News:WHO declares Tuberculosis – ‘An Emergency’ in Afr 2Health News:Genetic Cause For Farsightedness Discovered 2Health News:Radio-guided Neurosurgery for treatment of Brain cancer 2Health News:General Anesthesia For Heroin Detoxification Is No Good 2
(Date:5/29/2015)... , May 29, 2015 /CNW/ - Alliance Principle Ingredients/Neutrical ... recalling the health product Galenic Health Ginger in ... lead for adolescents and children. The product currently ... children, but within acceptable limits for adult dosing. ... relieve digestive upset and disturbances. Alliance Principle Ingredients ...
(Date:5/29/2015)... May 29, 2015  Excite Medical was established by ... the years, Excite Medical, under the leadership of ... company, with a solid track record of providing unparalleled ... and distributor base.  Photo - ... Medical has been possible, in large part, due to ...
(Date:5/29/2015)... 2015  Fair Rate Funding, a leader in TV ... Delaware found Thursday that Boston ... pelvic organ prolapse (POP) and Stress Urinary Incontinence (SUI) ... hid the design flaws from the plaintiff, Deborah ... Transvaginal mesh, also known as TV ...
Breaking Medicine Technology:TV Mesh Lawsuit Funding Firm, Fair Rate Funding, Reports Delaware Woman Awarded $100 Million Against Boston Scientific in Pelvic Mesh Verdict. 2TV Mesh Lawsuit Funding Firm, Fair Rate Funding, Reports Delaware Woman Awarded $100 Million Against Boston Scientific in Pelvic Mesh Verdict. 3
... Avicena Group,Inc. (OTC Bulletin Board: AVGO), ... system therapeutics for neurodegenerative,diseases, announced today that ... (ALS) drug candidate, AL-02, will be presented ... will be held on December 1-3,2007, in ...
... Former HHS Secretary Tommy G. Thompson Addresses Executives Before Day-Long ... ... Oct. 17 Representatives from more than 50,Greater Washington nonprofit organizations ... (Deloitte), the,Nonprofit Roundtable of Greater Washington (Roundtable), the American Red,Cross of ...
Cached Medicine Technology:Survival Data for Avicena's Amyotrophic Lateral Sclerosis Drug Candidate, AL-02, to be Presented at 18th International Symposium on ALS/MND 2Survival Data for Avicena's Amyotrophic Lateral Sclerosis Drug Candidate, AL-02, to be Presented at 18th International Symposium on ALS/MND 3Deloitte and Nonprofit Roundtable Host Real-World Disaster Exercise as Next Step in Developing Preparedness Plan for Greater Washington Region 2Deloitte and Nonprofit Roundtable Host Real-World Disaster Exercise as Next Step in Developing Preparedness Plan for Greater Washington Region 3Deloitte and Nonprofit Roundtable Host Real-World Disaster Exercise as Next Step in Developing Preparedness Plan for Greater Washington Region 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: