Navigation Links
Deadly bacteria may mimic human proteins to evolve antibiotic resistance
Date:6/1/2011

FLAGSTAFF, Ariz. June 1, 2011 Deadly bacteria may be evolving antibiotic resistance by mimicking human proteins, according to a new study by the Translational Genomics Research Institute (TGen).

This process of "molecular mimicry" may help explain why bacterial human pathogens, many of which were at one time easily treatable with antibiotics, have re-emerged in recent years as highly infectious public health threats, according to the study published May 26 in the journal Public Library of Science (PLoS) One.

"This mimicry allows the bacteria to evade its host's defense responses, side-stepping our immune system," said Dr. Mia Champion, an Assistant Professor in TGen's Pathogen Genomics Division, and the study's author.

Using genomic sequencing, the spelling out of billions of genetic instructions stored in DNA, the study identified several methyltransferase protein families that are very similar in otherwise very distantly related human bacterial pathogens. These proteins also were found in hosts such as humans, mouse and rat.

Researchers found methyltransferase in the pathogen Francisella tularensis subspecies tularensis, the most virulent form of Francisella. Just one cell can be lethal. Methyltransferase is a potential virulence factor in this pathogen, which causes Tularemia, an infection common in wild rodents, especially rabbits, that can be transmitted to humans though bites, touch, eating or drinking contaminated food or water, or even breathing in the bacteria. It is severely debilitating and even fatal, if not treated.

Similar methyltransferase proteins are found in other highly infectious bacteria, including the pathogen Mycobacterium tuberculosis that causes Tuberculosis, a disease that results in more than 1 million deaths annually. The study also identified distinct methyltransferase subtypes in human pathogens such as Coxiella, Legionella, and Pseudomonas.

In general, these bacterial p
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cardiac Arrest Less Deadly in Exercise Facilities, Study Finds
2. Belly Fat + Heart Disease Can Be Deadly: Study
3. Gene Variant May Be Linked to Deadly Lung Fibrosis
4. Problem Drinking May Make Hospital Infections More Deadly
5. Possible new approach to treating deadly leukemia in babies
6. Newly discovered virus implicated in deadly Chinese outbreaks
7. Tanning bed exposure can be deadly when complicated by medication reactions
8. Study finds close linkage between a rare, deadly lung condition and blood cell abnormalities
9. Virus Unlikely to Advance Deadly Lung Disease: Study
10. Severe Heart Attack No More Deadly to Women Than Men
11. Lasers ID deadly skin cancer better than doctors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... CT (PRWEB) July 11, 2014 ... the nation’s only non-profit dedicated exclusively to cell ... that Joshua Corday has joined the organization as ... fundraising professional with deep experience securing gifts and ... served as Annual Giving Director for NewYork Presbyterian ...
(Date:7/11/2014)... Global enterprises today are shifting towards the ... activities. Managed services offer these global enterprises a strategic ... resulted into rising operational costs to companies. The aim ... be the global market driver for expanding the managed ... services market is estimated to grow from $142.75 billion ...
(Date:7/11/2014)... 11, 2014 Presently, disposable medical suppliers ... equipment and supplies segment. During the past two decades, ... growth (on an average 12.5% per year), primarily owing ... Currently, the US is the largest market for disposable ... of 40%. The second position is held by Europe ...
(Date:7/11/2014)... PROVIDENCE, R.I. -- Researchers from The Miriam ... under age 65 have significantly higher rates of ... with mobility impairments were less likely to attempt ... quit-smoking treatments may not be sufficient for this ... online in advance of print in the ...
(Date:7/11/2014)... of its kind has found that organic foods ... their conventional counterparts, including more antioxidants and fewer, ... at an unprecedented 343 peer-reviewed publications comparing the ... plant-based foods, including fruits, vegetables, and grains. The ... differences between organic and non-organic foods. , ...
Breaking Medicine News(10 mins):Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 2Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 2Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 3Health News:Miriam Hospital study examines smoking prevalence 2Health News:Major study documents nutritional and food safety benefits of organic farming 2Health News:Major study documents nutritional and food safety benefits of organic farming 3
... and the elderly have slower response times when they have ... research suggests that much of that slower response is a ... healthy older people can be trained to respond faster in ... cognitive skills in this area aren,t so different from younger ...
... celiac disease -- an autoimmune disorder associated with a ... than the general population to report symptoms of depression ... gluten-free diet, according to researchers at Penn State, Syracuse ... often suffer from abdominal pain, constipation, decreased appetite, diarrhea, ...
... Teens are more likely to be obese if they had ... toddlers, according to a new study. The findings echo ... ties with their parents were more likely to be obese ... the latest study, researchers examined U.S. National Institute of Child ...
... -- Quitting smoking is one of the most common ... with six of 10 smokers requiring multiple attempts before ... Association. However, preparing a quit-smoking plan can greatly ... the single most important step smokers can take to ...
... The quality of the emotional relationship between a mother ... that child to be obese during adolescence, a new ... characteristics between mothers and their children during their toddler ... terms of the child,s emotional security and the mother,s ...
... team of neuroscientists, led by researchers at Mayo Clinic ... brain disorder that may be much more common than once ... Nature Genetics , the researchers say they identified 14 ... of hereditary diffuse leukoencephalopathy with spheroids (HDLS). This ...
Cached Medicine News:Health News:Elderly can be as fast as young in some brain tasks, study shows 2Health News:Elderly can be as fast as young in some brain tasks, study shows 3Health News:Elderly can be as fast as young in some brain tasks, study shows 4Health News:Women with celiac disease suffer from depression, disordered eating 2Health News:Women with celiac disease suffer from depression, disordered eating 3Health News:Mother-Toddler Bond May Influence Teen Obesity 2Health News:How to Make Your Quit-Smoking Resolution Stick 2Health News:Study links quality of mother-toddler relationship to teen obesity 2Health News:Study links quality of mother-toddler relationship to teen obesity 3Health News:Study links quality of mother-toddler relationship to teen obesity 4Health News:'Rare' brain disorder may be more common than thought, say Mayo Clinic scientists 2Health News:'Rare' brain disorder may be more common than thought, say Mayo Clinic scientists 3
(Date:7/10/2014)... BURLINGTON, Mass. , July 10, 2014 /PRNewswire/ ... three-quarters of surveyed infectious disease (ID) specialists are ... Medicines Company,s Orbactiv (oritavancin) for use as OPAT, ... to prescribe these agents to their hospital inpatients. ... percent) of OPAT patients are initiated on OPAT ...
(Date:1/15/2014)... Sono-Tek Corporation (OTC BB: SOTK) today announced sales of  ... to sales of $2,202,000 for the prior year period, an ... also shown growth over the preceding quarter,s sales, continuing a ... year. Markets that experienced sales increases over the prior year ...
(Date:1/15/2014)... Mich. , Jan. 15, 2014 As health officials ... flu virus, select Meijer pharmacies in Michigan ... throat to eligible patients, enabling Meijer pharmacists to administer tests ... protocol set by a physician participating in the study. ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3
... Feb. 21, 2012 ConvaTec, a world-leading developer and ... care, today announces that Ken Berger will assume the ... the ConvaTec Board of Directors. Berger joins ... last ten years, most recently as Senior Vice President ...
... Feb. 21, 2012  Idenix Pharmaceuticals, Inc. (NASDAQ: IDIX ... overview at the Citi Global Healthcare Conference on February 27, ... New York City.   The live and archived ... of Events" in the Idenix Investor Center at ...
Cached Medicine Technology:ConvaTec Announces the Appointment of Ken Berger to the Position of CEO Effective March 6, 2012 2
Classic, stylish, and preppy, this collection features men's, women's and unisex styles....
The latest VALENTINO eyewear collection is a refined expression of sophisticated luxury,balancing ultimate feminine, chic styles against understated, minimalist mens models....
Stylish, elegant and feminine, these attractive frames provide refined and beautiful styles for women ages 40 and older....
The Nine West Eyewear collection is positioned to present today's styles with a sharp, edgy contemporary attitude tied into a clean design element....
Medicine Products: