Navigation Links
Deadly bacteria may mimic human proteins to evolve antibiotic resistance
Date:6/1/2011

FLAGSTAFF, Ariz. June 1, 2011 Deadly bacteria may be evolving antibiotic resistance by mimicking human proteins, according to a new study by the Translational Genomics Research Institute (TGen).

This process of "molecular mimicry" may help explain why bacterial human pathogens, many of which were at one time easily treatable with antibiotics, have re-emerged in recent years as highly infectious public health threats, according to the study published May 26 in the journal Public Library of Science (PLoS) One.

"This mimicry allows the bacteria to evade its host's defense responses, side-stepping our immune system," said Dr. Mia Champion, an Assistant Professor in TGen's Pathogen Genomics Division, and the study's author.

Using genomic sequencing, the spelling out of billions of genetic instructions stored in DNA, the study identified several methyltransferase protein families that are very similar in otherwise very distantly related human bacterial pathogens. These proteins also were found in hosts such as humans, mouse and rat.

Researchers found methyltransferase in the pathogen Francisella tularensis subspecies tularensis, the most virulent form of Francisella. Just one cell can be lethal. Methyltransferase is a potential virulence factor in this pathogen, which causes Tularemia, an infection common in wild rodents, especially rabbits, that can be transmitted to humans though bites, touch, eating or drinking contaminated food or water, or even breathing in the bacteria. It is severely debilitating and even fatal, if not treated.

Similar methyltransferase proteins are found in other highly infectious bacteria, including the pathogen Mycobacterium tuberculosis that causes Tuberculosis, a disease that results in more than 1 million deaths annually. The study also identified distinct methyltransferase subtypes in human pathogens such as Coxiella, Legionella, and Pseudomonas.

In general, these bacterial p
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cardiac Arrest Less Deadly in Exercise Facilities, Study Finds
2. Belly Fat + Heart Disease Can Be Deadly: Study
3. Gene Variant May Be Linked to Deadly Lung Fibrosis
4. Problem Drinking May Make Hospital Infections More Deadly
5. Possible new approach to treating deadly leukemia in babies
6. Newly discovered virus implicated in deadly Chinese outbreaks
7. Tanning bed exposure can be deadly when complicated by medication reactions
8. Study finds close linkage between a rare, deadly lung condition and blood cell abnormalities
9. Virus Unlikely to Advance Deadly Lung Disease: Study
10. Severe Heart Attack No More Deadly to Women Than Men
11. Lasers ID deadly skin cancer better than doctors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne ... highest annual revenues in the past three years. Today, the ... dresses. , According to the sales manager of the company, ... them in 2015. This point can be reflected on the ...
(Date:1/22/2015)... Payday lending practices in four southern ... financial distress to the states that permit them, according ... Center on Race and Wealth. , While they generate ... loans at the same time substantially depress economic activity, ...
(Date:1/22/2015)... JJsHouse.com is a famous dress online store ... announces its latest collection of wedding dresses , and ... issue is the wedding dress on your big day; the ... life. Every bride wants to find the most suitable wedding ...
(Date:1/22/2015)... Richmond, VA (PRWEB) January 22, 2015 ... the power at the Science Museum of Virginia. Wicked ... 24. , Wicked Plants unearths 75 poisonous, carnivorous and ... traverse through each room to uncover the biochemical, physical ...
(Date:12/26/2014)... said that nothing makes a lady feel more feminine than ... shows its new selection of navy cocktail dresses , ... navy cocktail gowns are the cornerstones of the site’s cocktail ... dresses in bright neon colors can be dressed up or ...
Breaking Medicine News(10 mins):Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:Wicked Plants are taking over the Science Museum of Virginia 2Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2
... TeamStaff, Inc. (Nasdaq: TSTF) , a national provider of ... Company has completed an in-depth strategic review of its businesses ... and changing dynamics in the healthcare market. The analysis ... the board of directors and the executive management team led ...
... , DALLAS, Nov. 3 IBM ... of its Health Analytics Solution Center, part of a ... needed to help hospitals and medical staff improve decision-making and provide ... ) , The center will be hosted in the IBM Global ...
... Nov. 3 HealthSouth Corporation (NYSE: HLS ) today ... September 30, 2009. The results showed consolidated net operating revenues ... to $455.5 million for the third quarter of 2008, or ... a 5.3% quarter-over-quarter increase in patient discharges on both a ...
... Democratic Senators Tom Harkin and Mary Landrieu and Congresswoman ... from Des Moines, Iowa; Gwendolyn Barnes, a small business ... business owner from Richmond, Virginia; and other small business ... this morning to discuss how health insurance reform will ...
... The American Society of Hematology (ASH) is honoring two prominent ... role they play in the training and career development of ... Arthur W. Nienhuis, MD, will receive their awards during the ... who will be receiving the Mentor Award for Basic Science, ...
... Four researchers from Thomas Jefferson University have received $3.9 ... American Recovery and Reinvestment Act. The NIH has ... for this new initiative called the Challenge Grants in ... across the country have been funded. This program supports ...
Cached Medicine News:Health News:TeamStaff Announces Revised Business Strategy; Chief Executive Officer to Step Down on Completion of Search For Successor 2Health News:TeamStaff Announces Revised Business Strategy; Chief Executive Officer to Step Down on Completion of Search For Successor 3Health News:IBM Launches Health Analytics Center 2Health News:IBM Launches Health Analytics Center 3Health News:IBM Launches Health Analytics Center 4Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 2Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 3Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 4Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 5Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 6Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 7Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 8Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 9Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 10Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 11Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 12Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 13Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 14Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 15Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 16Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 17Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 18Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 19Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 20Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 21Health News:HealthSouth Reports Strong Results for Third Quarter 2009 and Increases 2009 Guidance 22Health News:Democratic Senators, Congresswoman, Small Business Owners Discuss Impact of Health Insurance Reform on Small Businesses 2Health News:Democratic Senators, Congresswoman, Small Business Owners Discuss Impact of Health Insurance Reform on Small Businesses 3Health News:The American Society of Hematology to honor inspirational hematologists with Mentor Awards 2Health News:Jefferson researchers receive $3.9 million in Challenge grants 2Health News:Jefferson researchers receive $3.9 million in Challenge grants 3
(Date:1/23/2015)... JUNCTION, N.J. , Jan. 23, 2015  CytoSorbents ... company commercializing its CytoSorb® extracorporeal cytokine adsorber to ... patients, announced the receipt of $385,642, net of ... participant of the Technology Business Tax Certificate Transfer ...
(Date:1/23/2015)... 2015 Gem Pharmaceuticals announced today that the initial ... the Company,s Phase 2 clinical trial.  This open-label study ... compound, GPX-150 (an investigational medication), in approximately 30 adults ... Logo - http://photos.prnewswire.com/prnh/20150123/170966LOGO ...
(Date:1/23/2015)... China , Jan. 23, 2015 Tianyin Pharmaceutical ... company that specializes in the development and sale of ... generics and active pharmaceutical ingredients (API) today announced the ... (JCM) API operation. 1. Following the September ...
Breaking Medicine Technology:CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4
... 2, 2011 Naviscan, Inc., announces the European ... scanner at two prestigious radiology conferences in Vienna. ... Breast Imaging (EUSOBI) Annual Scientific Meeting, a podium ... Emission Mammography) data demonstrating PEM,s ability to reduce ...
... (Nasdaq: PCYC ) today announced that further ... anti-arthritis activity in mice and rats, has been suspended ... studies.  The company hopes to have a new clinical ... PCI-45292 has been under preclinical development for approximately ...
Cached Medicine Technology:Naviscan Announces European Launch of Positron Emission Mammography 2Update on Preclinical Finding and Development Timeline for PCI-45292 2Update on Preclinical Finding and Development Timeline for PCI-45292 3
Heine Beta 200 Streak Retinoscope 2.5v...
Keeler Professional Combi Retinoscope with new slimline handle and lithium or dry cell option....
System, English (Continental cord), 230 VAC....
Micro-mini fiber optic light....
Medicine Products: