Navigation Links
'Dead' gene comes to life, puts chill on inflammation, Stanford researchers find
Date:7/23/2013

le genes, don't code for proteins. More than 11,000 pseudogenes one for every two protein-coding genes have been identified in the human genome. Scientists believe pseudogenes are copies of actual genes that, during the replication of some ancestral organism's germ cell, were accidentally inserted into the genome and, redundant but harmless, came along for the evolutionary ride. Over the intervening eons, these genetic doppelgangers have roamed along the genome, mutated and decayed to the point where, it is believed, they no longer do anything at all.

"Pseudogenes have been considered to be completely silent, ignored by cells' DNA-reading machinery," Chang said. "But we got a real surprise. When a cell is subjected to an inflammatory stress signal, it's like Night of the Living Dead."

Equally surprising, Chang said, is that different signaling chemicals or microbial components (such as bits of bacterial cell walls or of viral DNA) wake up different groups of lncRNA-encoding DNA sequences, including pseudogenes. "They're not really dead, after all. They just need very specific signals to set them in motion."

Lethe was one such pseudogene tripped off by stimulation of NF-kappa-B. Lethe directly interfered with the complex's ability to seat itself on appropriate DNA sequences, shutting down the pro-inflammatory genes the transcription factor ordinarily activates.

Several pseudogenes were activated in a selective manner. For example, TNF-alpha and another circulating signaling protein but not microbial parts activated Lethe.

Because some pseudogenes sit near protein-coding genes, some scientists have argued that the generation of RNA transcripts from the pseudogenes is simply an artifact of normal transcription of full-fledged protein-coding genes. "There's a tendency to assume it's some protein-coding gene that NF-kappa-B is really targeting, and to downplay the activation of a lncRNA as noise, a 'ripple effect' like the
'/>"/>

Contact: Bruce Goldman
goldmanb@stanford.edu
650-725-2106
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Is that bacteria dead yet?
2. USC research IDs potential treatment for deadly, HIV-related blood cancer
3. Imprelis Lawsuit News: Minnesota Property Owners Report Imprelis Tree Damage as June 28 Deadline to Opt Out of Imprelis Lawsuit Settlement Approaches, Reports Wright & Schulte
4. Imprelis Lawsuit Filed by Wright & Schulte Just Before Impending June 28 Deadline to Opt Out of Class-Action Imprelis Lawsuit Settlement
5. Virus combination effective against deadly brain tumor, Moffitt Cancer Center study shows
6. Entry Deadline for min’s Integrated Marketing Awards Is This Friday, June 21
7. Dr. Bernabe Vazquez Speaks on Miami Woman’s Deadly Silicone Butt Injection
8. Whooping cough can be deadly for infants, but 61 percent of adults dont know their vaccine status
9. Imprelis Lawsuit Deadline: Gilman Law LLP Warns Property Owners Who Sustained Imprelis Tree Damage That They Must Act Now, Before July 28th Court Imposed Deadline
10. Mesothelioma Victims Center Urges Diagnosed Victims Of Mesothelioma To Focus On Compensation Deadlines And To Call them For The Names Of The Nation's Most Skilled Lawyers
11. Strength Training Program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... 29 Four leaders,from the worlds of medicine, research, ... national Board of Trustees of the March of,Dimes Foundation, ... who serve as volunteers, represent the public,in governing the ... The new trustees are:, Miriam Arond, Director of ...
... ROCK, Ark., July 29 Heifer International and,Elanco ... partnership,agreement. Heifer International is a world hunger organization. ... Indiana, that has,offices in 30 countries around the ... animal health and productivity., The partnership will ...
... organized population-based breast cancer screening program in Norway and ... self-referrals in Vermont are equally sensitive for detecting cancer, ... the Journal of the National Cancer Institute . ... in Norway. , Breast cancer screening in the United ...
... Ultra-miniature bialy-shaped particles called nanobialys because they ... popular in New York City could soon ... tumors or atherosclerotic plaques. , The nanobialys ... diagnostic and disease-fighting nanoparticles developed by researchers in ...
... $0.56 Net Income Per Share, SAN JOSE, Calif., ... ), a leading provider of medical devices,for the minimally ... for the second quarter ended June 30, 2008., ... 85% to $31.9,million compared with $17.2 million for the ...
... Q2 net revenues of $79.9 million increase 6.9 percent sequentially ... $0.06 per diluted share - Case ... cost-saving measures including a workforce reduction, SANTA CLARA, Calif., July ... results for the,second quarter of fiscal 2008, ended June 30, 2008., ...
Cached Medicine News:Health News:Four Named to March of Dimes Board of Trustees 2Health News:Four Named to March of Dimes Board of Trustees 3Health News:Four Named to March of Dimes Board of Trustees 4Health News:Four Named to March of Dimes Board of Trustees 5Health News:Four Named to March of Dimes Board of Trustees 6Health News:Four Named to March of Dimes Board of Trustees 7Health News:Heifer and Elanco Announce Charitable Partnership 2Health News:2 different breast cancer screening strategies are equally effective 2Health News:New disease-fighting nanoparticles look like miniature pastries 2Health News:New disease-fighting nanoparticles look like miniature pastries 3Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 2Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 3Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 4Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 5Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 6Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 7Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 8Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 2Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 3Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 4Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 5Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 6Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 7Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 8Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 9Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 10Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 11Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 12Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 13
(Date:12/24/2014)... , Dec. 24, 2014  The International Trade Commission ... ResMed (RMD) against BMC Medical. In a notice issued on ... found that ResMed,s patent on its humidifier was invalid. ... a "monumental win". "We are very excited with the ITC,s ... position that we have taken since the very beginning on ...
(Date:12/24/2014)... 24, 2014  Diplomat Pharmacy, Inc. (NYSE: ... proud to announce Jennifer Hagerman , Pharm.D., AE-C, ... take office as the president of the Michigan Pharmacists ... will take place Feb. 28, 2015, at the MPA ... the Renaissance Center in Detroit, Michigan ...
(Date:12/24/2014)... NEW YORK and LONDON ... in global orthopedic industry are expected to grow at ... consumption in terms of value and volume. Hip, knee ... the developed world while in emerging economies they have ... failure rates are challenging the use of composites. Non-metallic ...
Breaking Medicine Technology:ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3
... U.S. Agency for International Development (USAID) continues to provide ... the midst of an expanding humanitarian crisis. An ailing ... the people of Zimbabwe in danger of other health ... supporting emergency Indoor Residual Spraying (IRS) to shore up ...
... high Dk hybrid contact lens manufacturer, announced today the ... fund the development and clinical trials for next-generation hybrid ... efforts globally. De Novo Ventures of Palo Alto, CA, ... round. Bio-Star Private Equity Fund joined Series A and ...
Cached Medicine Technology:USAID Provides Malaria Assistance to Zimbabwe 2SynergEyes, Inc. Raises $13.3 Million in 'Series C' Financing 2
... it is not the Flu? Streptococcus pneumoniae ... "flu-like" infections. The easy-to-use, rapid, urine-based test ... the new 4 hour guidelines. Rapid identification ... patient outcomes and lower overall health care ...
... newest technology available in acrylic lens design. ... material and design properties to achieve truly ... Unique foldable hydrophobic acrylic material , ... , High index of refraction ...
12 mm single use, reloadable laparoscopic linear stapler with titanium staples....
Single Use Loading Units (SULU's) Knifeless for use with MULTIFIRE ENDO GIA™ 30 12 mm (Single Use Staplers with Titanium Staples)....
Medicine Products: