Navigation Links
'Dead' gene comes to life, puts chill on inflammation, Stanford researchers find
Date:7/23/2013

le genes, don't code for proteins. More than 11,000 pseudogenes one for every two protein-coding genes have been identified in the human genome. Scientists believe pseudogenes are copies of actual genes that, during the replication of some ancestral organism's germ cell, were accidentally inserted into the genome and, redundant but harmless, came along for the evolutionary ride. Over the intervening eons, these genetic doppelgangers have roamed along the genome, mutated and decayed to the point where, it is believed, they no longer do anything at all.

"Pseudogenes have been considered to be completely silent, ignored by cells' DNA-reading machinery," Chang said. "But we got a real surprise. When a cell is subjected to an inflammatory stress signal, it's like Night of the Living Dead."

Equally surprising, Chang said, is that different signaling chemicals or microbial components (such as bits of bacterial cell walls or of viral DNA) wake up different groups of lncRNA-encoding DNA sequences, including pseudogenes. "They're not really dead, after all. They just need very specific signals to set them in motion."

Lethe was one such pseudogene tripped off by stimulation of NF-kappa-B. Lethe directly interfered with the complex's ability to seat itself on appropriate DNA sequences, shutting down the pro-inflammatory genes the transcription factor ordinarily activates.

Several pseudogenes were activated in a selective manner. For example, TNF-alpha and another circulating signaling protein but not microbial parts activated Lethe.

Because some pseudogenes sit near protein-coding genes, some scientists have argued that the generation of RNA transcripts from the pseudogenes is simply an artifact of normal transcription of full-fledged protein-coding genes. "There's a tendency to assume it's some protein-coding gene that NF-kappa-B is really targeting, and to downplay the activation of a lncRNA as noise, a 'ripple effect' like the
'/>"/>

Contact: Bruce Goldman
goldmanb@stanford.edu
650-725-2106
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Is that bacteria dead yet?
2. USC research IDs potential treatment for deadly, HIV-related blood cancer
3. Imprelis Lawsuit News: Minnesota Property Owners Report Imprelis Tree Damage as June 28 Deadline to Opt Out of Imprelis Lawsuit Settlement Approaches, Reports Wright & Schulte
4. Imprelis Lawsuit Filed by Wright & Schulte Just Before Impending June 28 Deadline to Opt Out of Class-Action Imprelis Lawsuit Settlement
5. Virus combination effective against deadly brain tumor, Moffitt Cancer Center study shows
6. Entry Deadline for min’s Integrated Marketing Awards Is This Friday, June 21
7. Dr. Bernabe Vazquez Speaks on Miami Woman’s Deadly Silicone Butt Injection
8. Whooping cough can be deadly for infants, but 61 percent of adults dont know their vaccine status
9. Imprelis Lawsuit Deadline: Gilman Law LLP Warns Property Owners Who Sustained Imprelis Tree Damage That They Must Act Now, Before July 28th Court Imposed Deadline
10. Mesothelioma Victims Center Urges Diagnosed Victims Of Mesothelioma To Focus On Compensation Deadlines And To Call them For The Names Of The Nation's Most Skilled Lawyers
11. Strength Training Program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... November 24, 2014 "My friend was ... trying to cross the street in his motorized wheelchair," ... saw him. I came up with this idea so ... night." , He developed the Safety Lites to make ... low-lighting conditions. The device ensures that motorists can see ...
(Date:11/23/2014)... 2014 The report, “Market Snapshot: ... 2020 - Asia-Pacific” provides quantitative analysis of the ... minimally invasive body contouring devices, non-invasive body contouring ... market size data by revenue and volume over ... China, Japan, South Korea, Australia and India. It ...
(Date:11/23/2014)... 21, 2014 (HealthDay News) -- Close friends have more ... group does, a new study says. "We,ve ... have an influence on individual alcohol use, but there ... peer group and the friend group,s influence on those ... School of Public Health, said in a university news ...
(Date:11/23/2014)... To show thanks to new and old customers, ... white evening dresses for weddings. Customers who need custom ... is a distinguished dress manufacturer, and it is among the ... for a very long time. The CEO of this company ... be able to buy not only a beautiful dress, but ...
(Date:11/23/2014)... Asher Milgrom, is a celebrity ... was recently featured on International Business Times. ... CEO of American Medical Aesthetics & Wellness, also known ... full scholarship to attend an M.D./Ph.D program at University ... University of Chicago, where his field of study was ...
Breaking Medicine News(10 mins):Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 4Health News:Close Friends May Be Key to Teens' Drinking 2Health News:iFitDress.com: Wonderful White Evening Dresses Now Available 2Health News:Asher Milgrom Is the Founding Doctor of AMA Skincare and Is Featured in the International Business Times 2Health News:Asher Milgrom Is the Founding Doctor of AMA Skincare and Is Featured in the International Business Times 3Health News:Asher Milgrom Is the Founding Doctor of AMA Skincare and Is Featured in the International Business Times 4
... a large-scale clinical trial presented today at the annual ... provide the first strong evidence of the benefit of ... are at elevated risk for breast cancer. In addition, ... depicting early breast cancer. "We found that annual ...
... , ... new market research report is available in its catalogue: ... Forecasts to 2015 , http://www.reportlinker.com/p0166596/Global-In-Vitro-Diagnostics-Market-Analysis-and-Forecasts-to-2015.html , ... 2015 , Summary , GlobalData,s "Global In ...
... , ... Reportlinker.com announces that a new market research ... The Future of Monoclonal Antibodies - Market Forecasts ... Analysis , http://www.reportlinker.com/p0166816/The-Future-of-Monoclonal-Antibodies---Market-Forecasts-to-2015-Competitive-Benchmarking-Product-Pipeline-and-Deals-Analysis.html , ...
... , SACRAMENTO, Calif., Dec. 1 As health care reform ... as a care delivery model, renowned entrepreneur Henry J. Kaiser ... Kaiser,s eldest granddaughter, Carlyn Kaiser Stark, will accept the Spirit ... state ceremony in Sacramento this evening. , Kaiser,s greatest ...
... equal care, very preterm births more likely, British study finds ... are poor are more likely to deliver a very preterm ... receive equal care, a new British study shows. , The ... need to learn more about the association between economic status ...
... to analyze form and structural changes to colorectal liver ... according to research from The University of Texas M. ... in the Dec. 2 issue of JAMA . ... also known as Avastin, is associated with both improved ...
Cached Medicine News:Health News:Annual screening with breast ultrasound or MRI could benefit some women 2Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 2Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 3Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 4Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 5Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 6Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 7Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 8Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 9Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 10Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 11Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 12Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 13Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 14Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 15Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 16Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 17Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 18Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 19Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 20Health News:Reportlinker Adds Global In Vitro Diagnostics Market Analysis and Forecasts to 2015 21Health News:Reportlinker Adds The Future of Monoclonal Antibodies - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis 2Health News:Reportlinker Adds The Future of Monoclonal Antibodies - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis 3Health News:Reportlinker Adds The Future of Monoclonal Antibodies - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis 4Health News:Reportlinker Adds The Future of Monoclonal Antibodies - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis 5Health News:Reportlinker Adds The Future of Monoclonal Antibodies - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis 6Health News:Reportlinker Adds The Future of Monoclonal Antibodies - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis 7Health News:Reportlinker Adds The Future of Monoclonal Antibodies - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis 8Health News:Reportlinker Adds The Future of Monoclonal Antibodies - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis 9Health News:Reportlinker Adds The Future of Monoclonal Antibodies - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis 10Health News:Reportlinker Adds The Future of Monoclonal Antibodies - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis 11Health News:Reportlinker Adds The Future of Monoclonal Antibodies - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis 12Health News:Reportlinker Adds The Future of Monoclonal Antibodies - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis 13Health News:Health Care Pioneer Henry J. Kaiser Inducted Into The California Hall of Fame 2Health News:Health Care Pioneer Henry J. Kaiser Inducted Into The California Hall of Fame 3
(Date:11/22/2014)... , Nov. 22, 2014  Sprout Pharmaceuticals today announced positive ... that women treated with flibanserin up to 200 mg at ... were presented at the 20 th Annual Fall Scientific ... America in Miami . ... to the Complete Response Letter and the Formal Dispute Resolution ...
(Date:11/22/2014)... , Nov. 21, 2014 Statistics released from ... drunk driving increase astronomically during the holidays, beginning with ... many cities. The data, highlighted ... Systems as part of their annual Sober ... a picture of high-risk drinking and increased rates of ...
(Date:11/21/2014)... -- Alere Inc. (NYSE: ALR ), a global ... Cunningham as Vice President, Investor Relations. In this ... communications with the investment community. "As we ... increase shareholder value, it is critical that we effectively ... Executive Officer. "We are delighted that Juliet Cunningham ...
Breaking Medicine Technology:Sprout Pharmaceuticals Presents Phase 1 Clinical Trial Data Showing Treatment With Flibanserin Results In No Next-Day Driving Impairment 2Sprout Pharmaceuticals Presents Phase 1 Clinical Trial Data Showing Treatment With Flibanserin Results In No Next-Day Driving Impairment 3Alarming Stats Show Holiday Drinking an Issue for Many 2Alere Appoints Juliet Cunningham to Lead Investor Relations 2
... in Neurogastroenterology and Motility- MONTVALE, N.J., Oct. ... announced today the publication of,preclinical data demonstrating the ... of advanced glycated end-products (AGEs) and restore,neuronal nitric ... Loss,of gastrointestinal nNOS activity is one of the ...
... nearly 80% of patients, SAN FRANCISCO, Oct. 24 ... data from an ongoing phase 2,trial of XL880, an ... renal cell carcinoma (PRC). Of 19 patients with measurable,disease ... decrease in,tumor size (4-33%), including one patient with a ...
Cached Medicine Technology:Synvista Therapeutics' Alagebrium Shows Potential for use in Treating Diabetes-Related Gastrointestinal Complications 2Synvista Therapeutics' Alagebrium Shows Potential for use in Treating Diabetes-Related Gastrointestinal Complications 3Synvista Therapeutics' Alagebrium Shows Potential for use in Treating Diabetes-Related Gastrointestinal Complications 4Interim Phase 2 Data for Exelixis' XL880 Show Anti-Tumor Activity in Papillary Renal Cell Cancer 2Interim Phase 2 Data for Exelixis' XL880 Show Anti-Tumor Activity in Papillary Renal Cell Cancer 3Interim Phase 2 Data for Exelixis' XL880 Show Anti-Tumor Activity in Papillary Renal Cell Cancer 4Interim Phase 2 Data for Exelixis' XL880 Show Anti-Tumor Activity in Papillary Renal Cell Cancer 5
... as both regular and filter tips. Sterilized ... more efficient sterilization and are delivered with ... of irradiation. Sterilized Diamond Tips are ready ... Diamond Tips are wrapped in medical device ...
10 L, Bulk Recommended for 2, 5 and 10 L pipettes....
This extended 10 L tip additionally combats contamination by keeping your pipettor out of 1.5 L and 2.0 L tubes....
... to order tips. Each box contains 1000 tips ... contains 200 tips (4 bags of 50 tips). ... 200 tips per pack. Bulk Packs are sealed ... opened for quick access to Gilsons Diamond Tips. ...
Medicine Products: