Navigation Links
David Anderson to discuss what model organisms can teach us about emotion
Date:2/20/2010

Scientists know little about how the brain creates and controls emotions an uncertainty that presents a major obstacle in the effort to develop treatments for emotional disorders. "The study of the brain science of emotion is in its infancy," says Howard Hughes Medical Institute (HHMI) investigator David Anderson, "yet emotional and psychiatric disorders continue to take an enormous toll on human society."

On February 20, 2010, at the American Association for the Advancement of Science's Annual Meeting in San Diego, Anderson, a neuroscientist at the California Institute of Technology, will discuss how studies of model organisms such as mice and fruit flies can improve scientists' understanding of the neural basis of emotion. That understanding, he says, is essential for developing more specific therapies for emotion disorders such as depression, anxiety, or attention deficit hyperactivity disorder (ADHD).

Anderson explains that while functional magnetic imaging (fMRI) studies of the human brain have linked neural activity in specific regions of the brain to particular emotional responses, there are limits to what can be learned from these types of studies. "We cannot tell which of these hotspots represents the actual cause of an emotional response, and which of them represents a reaction to the response," he says.

To makes that distinction, scientists must alter the activity of brain circuits in a targeted way, and then determine the consequences of the changes on emotional behavior. Such experiments are not possible on human subjects, and so scientists turn to model organisms. Anderson, whose own studies at Caltech and HHMI's Janelia Farm Research Campus explore the link between neural circuitry and emotional behaviors such as fear and aggression in both mice and fruit flies, will discuss the power and limitations of these types of experiments.

"We are in the midst of a revolution in the development of new technologies for experimentally manipulating brain circuitry," he says. Molecular and genetic tools that allow scientists to control when specific neurons are turned on in model organisms is already beginning to transform scientists' understanding of many aspects of brain function, including sensation, perception, cognition, and motor control. Anderson's presentation will address how to best apply these tools to the study of emotion.

"We need to know which animals are most suitable for studying this complex subject," he says. The laboratory mouse is amenable to powerful genetics techniques and it has a brain structure that is fundamentally similar to that of humans. But, he says, mouse research is slow, costly, technically difficult, and presents ethical challenges. Invertebrate model organisms, like the fruit fly Drosophila melanogaster, have simpler brains, more powerful genetic tools, and allow for faster, less expensive studies. "But can one study emotional behavior in a fly?" Anderson asks.


'/>"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
Source:Eurekalert

Related medicine news :

1. WorldHeart Appoints David Pellone Chief Financial Officer
2. Statement of Eli Lilly and Company on Dr. David Egilman Settlement:
3. David Ward Joins OrthoSynetics(TM) as Western Region Sales Manager
4. The Law Offices of John David Hart: Texas Man Sues Medtronic in Body-Snatching Case
5. Mylan Announces Appointment of David A. Lillback as Senior Vice President and Global Head of Human Resources
6. St. Davids Medical Center Implements New Robotic Technology to Treat Common Heart Rhythm Disorders
7. David Grimes, FHI physician, inducted into Institute of Medicine
8. David Kahal Joins AXA Equitable as National Sales Manager
9. Leading Authority on Health Benefits, David Hom, Joins Board of Directors of Healthcare Technology Innovator, NavigatorMD, Inc.
10. Tree named in honor of Virginia Tech chemist David G.I. Kingston
11. David Luci Joins MacroChem as General Counsel and Vice President Corporate Development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... 2016 , ... ZyDoc , a New York-based medical ... Capture Methods for Input to Electronic Health Records: A Comparative Usability Study” has ... usability study demonstrate that a dictation-based method (“NLP Entry”) using ZyDoc’s MediSapien™ natural ...
(Date:12/8/2016)... ... 08, 2016 , ... David J. Dykeman , Ginger Pigott , ... will speak at DeviceTalks West, Dec. 12, 2016, at the Fairmont Newport Beach in ... the firm’s global Life Sciences & Medical Technology Group have been featured speakers at ...
(Date:12/8/2016)... ... 08, 2016 , ... STATEN ISLAND, N.Y., Nov. 24, 2016 ... the highest standards of trauma, maternity, cancer and chronic obstructive pulmonary disease (COPD) ... Dr. Daniel Messina. , Among the recognitions, the American College of Surgeons' (ACS) ...
(Date:12/8/2016)... California (PRWEB) , ... December 08, 2016 , ... ... has raised an $18M Series B led by Canvas Ventures . Other investors ... capital to scale its mobile platform to serve more consumers who are managing ...
(Date:12/8/2016)... ... December 08, 2016 , ... Coppin Insurance Agency, an insurance and financial ... around the Cape Coral area, is embarking on a charity drive with the goal ... , The Harry Chapin Food Bank of Southwest Florida works to provide fresh and ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 2016  Hanson Research, an innovative leader in ... diffusion testing instruments for the pharmaceutical industry, announced ... Inc. ("Teledyne"). The move is designed to deepen ... instruments, as well as expand resources for further ... and services. Logo - http://photos.prnewswire.com/prnh/20161208/446988LOGO ...
(Date:12/8/2016)... FRANCISCO , Dec. 8, 2016 ... today announced that it has closed a $23 ... McKesson Ventures and OrbiMed. The company seeks to ... time physicians spend on mandated EHR documentation. The ... scribe service that frees doctors from 3 hours ...
(Date:12/8/2016)... LITTLE FALLS, N.J., Dec. 8, 2016 CANTEL MEDICAL ... net income of $18,800,000, or $0.45 per diluted share, on ... the first quarter ended October 31, 2016. This compares with ... sales of $153,779,000 for the first quarter ended October 31, ... the first quarter ended October 31, 2016 to $21,323,000, or ...
Breaking Medicine Technology: