Navigation Links
Data re-analysis shows drug finasteride reduces risk for most prostate cancers
Date:5/20/2008

NEW YORK (May 20, 2008) -- A re-analysis of data from the landmark Prostate Cancer Prevention Trial (PCPT) finds that finasteride reduces the risk for prostate cancer without boosting the odds of aggressive tumors.

PCPT, which involved more than 18,000 men 55 years of age or over, was stopped early in June 2003 because researchers noted that while it reduced prostate cancer in men taking finasteride (Proscar) by up to 25 percent, men taking finasteride also appeared to have more aggressive prostate tumors if and when they did develop the disease.

That caused some experts to worry that finasteride was encouraging higher-grade cancers.

But a new analysis led by researchers at NewYork-Presbyterian Hospital/Weill Cornell Medical Center should lay that worry to rest.

"Finasteride has long been used by doctors to treat benign enlarged prostate -- it shrinks the prostate. So when we accounted for this shrinkage in prostate volume, the disparity in tumor aggressiveness between the finasteride and placebo groups vanished," says study lead author Dr. Steven A. Kaplan, professor of urology at Weill Cornell Medical College and a urologist at NewYork-Presbyterian Hospital/Weill Cornell Medical Center.

He and his colleagues will present their findings Tuesday, May 20, at the annual meeting of the American Urological Association, in Orlando.

Physicians grade the aggressiveness of prostate tumors on what's called the Gleason Score -- a grading of tumor characteristics, with scores ranging from 2 to 10 (10 indicating the most highly aggressive cancers). "After their initial analysis, the PCPT investigators discovered that men taking finasteride had fewer prostate cancers overall, but a higher incidence of grades 7, 8, 9 and 10 cancers," Dr. Kaplan explains.

This was worrying, since it is higher-grade, potentially metastatic prostate cancers that are the real cause for clinical concern. "Lower-grade cancers are oft
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New study shows promise in reducing surgical risks associated with surgical bleeding
2. New research shows how chronic stress worsens neurodegenerative disease course
3. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
4. Circulating fats kill transplanted pancreas cells, study shows
5. New Heart Pump Shows Promise in Trial
6. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
7. New Survey Shows Americans are Still Concerned About Food Safety, Yet Still Not Smart About What They Like to Eat
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Amid Improving Life Expectancy Rates, Risk of Premature Death is Still Significant for Americans, New Study Shows
10. Avocados may help prevent oral cancer, OSU study shows
11. New Poll Shows Public Distrusts Flawed Healthcare Approach Favored by Governor and Speaker in AB 8
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... Mabel’s Labels , the market ... an award-winning company established by four moms, today announced ... Tricia Mumby have been honored with a 2014 RBC ... PROFIT Award for Excellence in Entrepreneurship. , All 4 ... Mumby) accepted the award on behalf of Mabel’s Labels ...
(Date:11/28/2014)... 28, 2014 UniWigs.com, a leader in the wig ... Friday to the next Monday. This promotion features: , ... 40 items up to 70% off (no coupon code needed), ... > Free shipping on orders over $49 , Visit http://www.uniwigs.com ... days from Nov. 28th to Dec. 1st and the first 100 ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 "Most of my ... me to use crutches," said an inventor from Findlay, Ohio. ... convenient way to support my foot, which inspired me to ... to offer a convenient way to support an injured foot. ... around. It eliminates the need for crutches. The design redistributes ...
(Date:11/28/2014)... November 28, 2014 Before that Thanksgiving meal ... preparing for the Christmas shopping season. Today, people will stand ... Black Friday, the biggest retail shopping day of the year. ... electronic device, New Albany dentist Dr. Ronald Receveur ... improve oral health and literally brighten a few smiles. , ...
(Date:11/28/2014)... 2014 Most of the people attending a ... at Lake Prince Woods retirement community found out ... sentimental value but wouldn’t have made the cut to be ... his expertise in decorative and folk art and his appearances ... about trends in buying and selling antiques. Broadly speaking ...
Breaking Medicine News(10 mins):Health News:Mabel's Labels’ Co-Founders Named A Winner In The 2014 RBC Canadian Women Entrepreneur Awards Program; A Second-Time Win For The Brand 2Health News:Mabel's Labels’ Co-Founders Named A Winner In The 2014 RBC Canadian Women Entrepreneur Awards Program; A Second-Time Win For The Brand 3Health News:Pre-X'mas Crazy Sale Starts from $0 at UniWigs.com 2Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 2Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 3Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 4Health News:Antiques Appraiser Sheds Light on "Treasures" 2
... Effective Means to Provide Health Care Access to Millions ... The National Patient Advocate Foundation (NPAF) - a national, ... of improved patient access to health care through public ... announced this month the election of four new Executive ...
... possibility of remote monitoring for chronically ill patients will ... and Australia have devised a decentralized system to avoid ... a forthcoming issue of the International Journal of ... range of chronic illnesses, including diabetes, high blood pressure, ...
... Health Care Reform, Received More Industry Contributions Than ... and pharmaceutical manufacturers contributed $5.5 million to the ... House of Representatives during the last two election ... reform dominated political discourse, according to the nonprofit, ...
... Petfinder.com and Merial Team Up to Ensure Animal Welfare ... 9 Petfinder.com, the largest online database of adoptable ... generators to 500 shelters and rescue groups nationwide with ... to the Paws program, a disaster preparedness initiative launched ...
... with chemo and radiation , , MONDAY, March 9 ... chemotherapy drug temozolomide and radiotherapy increases survival for glioblastoma ... improvement persists for up to five years, say Swiss ... aggressive form of primary brain tumor. For more than ...
... DALLAS, March 9 Inspired by Beryl Co-Founder Barry Spiegelman ... The Beryl Institute is hosting the second annual ... at Sky Creek Ranch Golf Club in Keller, Texas. To ... the tournament will be presented to UCLA,s Neuro-Oncology Program, ...
Cached Medicine News:Health News:National Patient Advocate Foundation Announces 2009 Elections of Health Policy Leaders to Executive Board of Directors 2Health News:National Patient Advocate Foundation Announces 2009 Elections of Health Policy Leaders to Executive Board of Directors 3Health News:National Patient Advocate Foundation Announces 2009 Elections of Health Policy Leaders to Executive Board of Directors 4Health News:National Patient Advocate Foundation Announces 2009 Elections of Health Policy Leaders to Executive Board of Directors 5Health News:National Patient Advocate Foundation Announces 2009 Elections of Health Policy Leaders to Executive Board of Directors 6Health News:National Patient Advocate Foundation Announces 2009 Elections of Health Policy Leaders to Executive Board of Directors 7Health News:National Patient Advocate Foundation Announces 2009 Elections of Health Policy Leaders to Executive Board of Directors 8Health News:Peer-to-peer heart monitoring 2Health News:Consumer Watchdog: Health Insurers & Drug Companies Contributed $5.5 Million to Top 10 Senate and House Recipients Since 2005 2Health News:Consumer Watchdog: Health Insurers & Drug Companies Contributed $5.5 Million to Top 10 Senate and House Recipients Since 2005 3Health News:Consumer Watchdog: Health Insurers & Drug Companies Contributed $5.5 Million to Top 10 Senate and House Recipients Since 2005 4Health News:Consumer Watchdog: Health Insurers & Drug Companies Contributed $5.5 Million to Top 10 Senate and House Recipients Since 2005 5Health News:Petfinder.com Foundation 'Rescues' 500 Shelters and Rescue Groups Nationwide with $1 Million Worth of Generators 2Health News:Combo Treatment for Aggressive Brain Tumor May Lengthen Life 2Health News:Think About It. Barry Spiegelman Memorial Golf Classic Benefits Brain Cancer Research 2
(Date:11/26/2014)... , Nov. 26, 2014  Genomic Health, Inc. (Nasdaq: ... , Chairman, Chief Executive Officer and President, will participate ... Conference at The New York Palace Hotel in ... at 11:30 am Eastern Time (ET). To ... conference call, go to the  Investor Relations  section of ...
(Date:11/26/2014)... , November 26, 2014 Investor-Edge ... VVUS ), Horizon Pharma PLC (NASDAQ: ... and Johnson (NYSE: JNJ ), and Theravance Inc. ... companies can be accessed at: http://investor-edge.com/register . ... 4,758.25, up 0.07%, the Dow Jones Industrial Average edged 0.02% ...
(Date:11/26/2014)... 2014  CARsgen, a leader in the development of ... a variety of cancers, today announced the completion of ... China -based healthcare private equity fund.   ... the development of new therapeutics for liver, lung, stomach ... and Shanghai Renji Hospital, the company plans to initiate ...
Breaking Medicine Technology:Genomic Health to Present at the 26th Annual Piper Jaffray Healthcare Conference 2Genomic Health to Present at the 26th Annual Piper Jaffray Healthcare Conference 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5CARsgen Completes Series A Financing 2
... cell company,Neuralstem, Inc., (Amex: CUR ) announced ... a European patent EP0915968, covering the,"Isolation, Propagation and ... Central Nervous System of Mammals." The European patent,has ... Germany,Ireland, Spain, Sweden, Switzerland and the United Kingdom., ...
... In Migraine Pain ... 48 Hours Vs. Placebo, MENLO PARK, Calif., April ... from a clinical study of the company,s,novel investigational intranasal ... The placebo-controlled proof of concept study evaluated the ...
Cached Medicine Technology:Neuralstem Announces Issuance of Core Technology Patent in Europe 2ROXRO PHARMA Announces Positive Clinical Proof of Concept Results for Novel Intranasal Migraine Treatment 2ROXRO PHARMA Announces Positive Clinical Proof of Concept Results for Novel Intranasal Migraine Treatment 3
20 g MVR knife. Dimensions: 31.8 mm x 1.18 mm x 2.7 mm....
Full Handle Laseredge Spoon Blade Knife, 3.0 mm angled double bevel. Blade dimension: 11.0 mm (L) x 3.0 mm (W). Cut: 320....
Full Handle Laseredge Slit Blade Knife, 3.2 mm angled double bevel. Blade tip dimension: 14.4 mm x 3.2 mm x 4.0 mm....
Full Handle Laseredge Slit Blade Knife, 3.0 mm angled bevel up. Blade tip dimension: 14.4 mm x 3.0 mm x 3.7 mm....
Medicine Products: