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Data on novel IL-1 inhibitor protein for topical treatment of dry eye disease published
Date:2/18/2013

R1, 85-fold more tightly than IL-Ra, translating into a 100-fold increase in potency in vivo.
  • EBI-005 is more thermally stable than IL-1Ra, indicating potential for a room temperature-stable product.
  • EBI-005 has been rationally designed by chimerizing two IL-1 receptor ligands, IL-1β and IL-1Ra, to create an optimized receptor antagonist, for topical ocular administration.
  • As a rationally-designed antagonist, EBI-005 represents a novel approach to therapeutic design that can potentially be exploited for other proteins in the IL-1 and FGF families.


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