Navigation Links
Data mining detects signs of Lou Gehrig's disease in gene carriers long before symptoms appear
Date:8/3/2008

WASHINGTON Inspired by the use of microarray chips that look for gene combinations, psychologists are using "pattern array" software to spot movements in rats that might help them predict diseases such as Lou Gehrig's syndrome.

A report in the August issue of Behavioral Neuroscience, published by the American Psychological Association, describes how this novel use of data mining may enable investigators to test therapies to delay or even prevent disease, starting with hereditary forms.

The authors demonstrated their original software on mutant rats used as an animal model of amyotrophic lateral sclerosis (ALS), a progressive and fatal neurodegenerative disease that's inherited about one in 10 times. (The origins of the other cases are still under investigation.) The disease, which attacks the nerve cells that control movement, is identified with Yankee slugger Lou Gehrig, who died of ALS in 1941, two years after diagnosis.

Researchers led by Neri Kafkafi, PhD, of the Maryland Psychiatric Research Center, part of the University of Maryland's School of Medicine, mathematically analyzed about 50,000 predetermined movement patterns that resulted when rats roamed freely, one by one, in a small arena. The software created an abstract space defined by combinations of behavior such as speed, acceleration and direction of movement. Mining the resulting behavioral data enabled researchers to test many more facets of behavior than they could analyze manually.

After videotaping the movement of two groups of rats one type with the mutation that results in an ALS-type syndrome, the other type normal controls -- the scientists used the computer to "pan" for differences between groups and identified a unique motor pattern in mutant rats two months before disease onset (which would equate to roughly five to 10 years in humans).

Of the multitude of behavior patterns analyzed, the predefined "heavily braking while slightly
'/>"/>

Contact: Public Affairs Office
public.affairs@apa.org
202-336-5700
American Psychological Association
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Global Access Project (GAP) Study Examining Patients Access to Cancer Care Featured in the Journal of the American Medical Association (JAMA)
2. Past Earnings Play Role in Determining SSDI Benefits
3. PET/CT scan could be valuable noninvasive tool for determining stages of ovarian cancer
4. Fitness a Key Element in Determining Male Diabetics Longevity
5. Determining genetic signature of lung tumors can help guide treatment
6. New Method Proposed for Determining Which Patients Should Get Treatment for Colorectal Cancer
7. New method proposed for determining which patients should get treatment for colorectal cancer
8. Study names 5 factors of social ills in energy, mining and logging communities
9. MIRARCO, Canadian Light Source agreement lights way to greener mining
10. UHW to SEIU, Nursing Home Chain: Stop Undermining Workers
11. UHW to Nursing Home Chain: Stop Undermining Workers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2015)... Colorado spine surgeon Donald Corenman, MD, ... popular spine education website NECKANDBACK.COM and his ... Media. This website has been redesigned to help patients ... spine, causes of neck and back pain, and conditions ... and personally answers questions in the neck and back ...
(Date:4/28/2015)... The buyer power score for ... indicating a medium level of buyer power in the ... equal power during negotiations. One factor helping buyer power ... health insurance policy from an insurance carrier (such as ... choose to self-fund their own policy or forgo insurance ...
(Date:4/28/2015)... It’s not all about the law at the Law ... litigation and plaintiff’s personal injury lawyer that has also served ... also about giving back to the community. This is ... Research Center Innovator’s Network. , “I believe there is a ... can and do good community-focused work in their communities,” said ...
(Date:4/28/2015)... SeniorCare.com has published the Misconception ... problem Americans have regarding aging and long-term care needs. ... services as they age, 63% of Americans do NOT ... the report, Carol Marak of SeniorCare.com interviewed 44 senior ... Care Association and The Scan Foundation. The experts discuss ...
(Date:4/28/2015)... Dead or damaged trees can quickly turn into ... cases, tree removal by a skilled team is recommended as ... , In their latest article , Precision Tree ... property owners today. Each method requires skill and expertise that ... , The article states that, “Tree removal is not “one ...
Breaking Medicine News(10 mins):Health News:Colorado Spine Surgeon Donald Corenman, MD, DC Launches Updated Version of NECKANDBACK.COM and Popular Back Pain Forum ASKSPINEDOC.COM 2Health News:Colorado Spine Surgeon Donald Corenman, MD, DC Launches Updated Version of NECKANDBACK.COM and Popular Back Pain Forum ASKSPINEDOC.COM 3Health News:New Data for Group Health Insurance Procurement Category Market Research Report from IBISWorld 2Health News:New Data for Group Health Insurance Procurement Category Market Research Report from IBISWorld 3Health News:New Data for Group Health Insurance Procurement Category Market Research Report from IBISWorld 4Health News:Seattle Attorney Paul Schneiderman Helping to Combat Cancer 2Health News:SeniorCare.com Report: America Has a Major Misconception on Aging 2Health News:Tree Removal Methods and Services Discussed in Recent Article by Precision Tree Services 2
... Jan. 28 Prime Companies, Inc. (Pink Sheets: PCIR) ... that will allow it to spin off its wholly ... 2007, to a San Diego firm which, once it ... 15 percent of the new company.The agreement with TransPacific ...
... Essential Hospital Guide to Get Your Loved One Out Alive," by ... Health Book of the Year by Allbooks Review Editor,s Choice Awards ... ... 2009 -- "Critical Conditions: The Essential Hospital Guide to Get Your ...
... of Health Strategies & Solutions, Inc the largest healthcare consultant in ... her expertise in management, governance, finance, operations and medical staff. ... ... The nation,s leading healthcare consulting firm, Health Strategies & ...
... A University of Rochester Medical Center study challenges common assumptions ... some people, surprisingly high levels remain in the body even ... suggests that BPA exposure may come from non-food sources, or ... journal Environmental Health Perspectives published the research online ...
... Jan. 27 Minnesotans with chronic,conditions and disabilities ... under the proposed budget of Gov. Tim Pawlenty, ... Center. , "As a ... thousands of Minnesotans following an illness, surgery or ...
... officials say company distributed ,adulterated, peanut butter products in ... -- The Georgia facility that produced the peanut butter ... in the past distributed questionable peanut butter product, U.S. ... 2008, Peanut Corporation of America, which owns the now-closed ...
Cached Medicine News:Health News:Prime Companies Reaches Agreement to Spin Off Subsidiary; Shareholders Gain 15 Percent Stake in New Telecommunications Company 2Health News:"Critical Conditions" Wins Best Health Book of the Year Awards 2Health News:New Employee of the Nations Largest Healthcare Consulting Firm 2Health News:Rochester study raises new questions about controversial plastics chemical 2Health News:Rochester study raises new questions about controversial plastics chemical 3Health News:Courage Center Experts Disagree With Gov. Pawlenty's Proposed Budget Cuts 2Health News:Courage Center Experts Disagree With Gov. Pawlenty's Proposed Budget Cuts 3Health News:Salmonella Outbreak Plant Shipped Dubious Product Before: U.S. Health Officials 2Health News:Salmonella Outbreak Plant Shipped Dubious Product Before: U.S. Health Officials 3
(Date:4/27/2015)... ALEXANDRIA, Va. and WASHINGTON ... of Specialty Pharmacy (NASP) and SmartBrief recently partnered to ... with a snapshot of the top news in the ... specialty pharmacies, pharmaceutical and biotechnology manufacturers, GPOs, distributors and ... free resource will launch on April 27, 2015. ...
(Date:4/27/2015)... -- The North America ... $4,211.2 million by 2019, at a CAGR of 5.0% from ... the North America ophthalmology surgery device ... It also provides a glimpse of the segmentation of this ... tables and figures. http://www.micromarketmonitor.com/market/north-america-ophthalmology-surgery-devices-9102894245.html ...
(Date:4/27/2015)... The North America ... and geography and includes analysis and forecast of revenue. This ... expected to reach $829.9 million by 2019, at a CAGR ... the TOC of the North America Optical microscopy market report, ... also provides a glimpse of the segmentation in this market, ...
Breaking Medicine Technology:NASP and SmartBrief Partner on Specialty Pharmacy SmartBrief 2North America Ophthalmology Surgery Device Market is Expected to Reach $4,211.2 Million by 2019, at a CAGR of 5.0% From 2014 to 2019 2North America Ophthalmology Surgery Device Market is Expected to Reach $4,211.2 Million by 2019, at a CAGR of 5.0% From 2014 to 2019 3North America Optical Microscopy Market is Expected to Reach $829.9 Million by 2019, at a CAGR of 3.0% From 2014 to 2019 2North America Optical Microscopy Market is Expected to Reach $829.9 Million by 2019, at a CAGR of 3.0% From 2014 to 2019 3
... Necessary For Diabetic Patients, BOSTON, Sept. 13 ... the United States alone. Coronary artery,disease (CAD) is a ... ischemia is common, and cardiac death or myocardial,infarction may ... the Detection of Ischemia in Asymptomatic Diabetics (DIAD),Study, presented ...
... Australia, Sept. 12 Sunshine Heart (ASX: SHC),a ... assist,technologies, today announced that it has received conditional ... U.S. Food and Drug,Administration (FDA) to begin its ... in patients with moderate heart failure. C-Pulse is,an ...
Cached Medicine Technology:Screening for Ischemia in Asymptomatic Patients With Type 2 Diabetes: Five- Year Outcomes in the DIAD Study 2Sunshine Heart Announces IDE Approval To Begin C-Pulse U.S. Clinical Feasibility Trial 2Sunshine Heart Announces IDE Approval To Begin C-Pulse U.S. Clinical Feasibility Trial 3
Bipolar semi-floating pacing lead for temporary stimulation of the heart especially in emergency cases of bradycardial arrhythmias or for recording intracardiac ECGs....
VascoStim 2F are bipolar temporary pacing leads to be used in conjunction with thermodilution catheters with implemented paceport-channel....
Unipolar Ventricular Lead...
The Guidant Fineline leads are bipolar endocardial and designed for permanent implantation with pulse generators for cardiac pacing....
Medicine Products: