Navigation Links
Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting
Date:11/1/2009

28 weeks or 36 weeks, respectively. Patients without RVR receive a 48-week boceprevir-based regimen. RVR in these studies is defined as undetectable virus (HCV RNA) in plasma at 4 weeks after the addition of boceprevir (treatment week 8).

Boceprevir Response Guided Therapy to Determine Treatment Duration

In a poster presentation at AASLD,(2) researchers reported that patients in the lead-in arms (4 weeks of PEGINTRON and REBETOL followed by the addition of boceprevir) of the Phase II HCV SPRINT-1 study who had RVR and were treated for 28 weeks achieved an 82 percent SVR (54/66). Patients in the lead-in arms who did not have RVR, but had undetectable virus by treatment week 16, and were treated for 48 weeks achieved a 79 percent SVR (15/19). These results doubled the 38 percent SVR (39/104) achieved by patients in the control group receiving 48 weeks of peginterferon and ribavirin alone. Overall, 64 percent of patients in the lead-in arms achieved RVR (132/206).

"These results are very exciting and provide important insights to help further define response guided therapy with boceprevir using a peginterferon and ribavirin lead-in strategy," Kwo said. "Building on the RVR rate seen in this Phase II study, the boceprevir Phase III study in treatment-naïve patients is designed to confirm whether the majority of patients can be treated with a 28-week boceprevir-based regimen."

SVR was the primary efficacy endpoint of the HCV SPRINT-1 study. Based on an intent-to-treat analysis (ITT), the 28-week and 48-week lead-in boceprevir arms had SVR rates of 56 percent (58/103) and 75 percent (77/103), respectively, and the no lead-in boceprevir arms had SVR rates of 54 percent (58/107) and 67 percent (69/103), respectively, compared to 38 percent SVR for the control group.(3-5)

In the HCV SPRINT-1 study, the most common adverse events reported in the boceprevir arms were fatigue, anemia, nausea and headache.
'/>"/>

SOURCE Schering-Plough Corporation
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine news :

1. Canary Foundation Commits to Supporting New Platform for Cancer Diagnostics
2. Food 4 Less Stores Giving Hope a Hand(R) in October by Supporting Breast Cancer Awareness Initiatives
3. Ralphs Stores Giving Hope a Hand(R) in October by Supporting Breast Cancer Awareness Initiatives
4. AstraZeneca Accepts Secretary of Defense Award for Supporting Employees Serving in National Guard and Reserve
5. Anthem Blue Cross and Blue Shield Foundation Grant Supporting American Diabetes Associations Family Link Program In Connecticut
6. livethesource(TM) Hosts Company Launch Event While Supporting The Brent Shapiro Foundations Annual Sober Night Out
7. CMSA Announces New Model ACT Supporting Case Management Programs
8. Hospice Foundation of America Presents New Educational Webinar on Supporting People with Intellectual Disabilities through Illness, Grief and Loss
9. The Sensory Research Center (SRC) Offers 2 for 1 Tickets for Benefit Concert Supporting Autism, Downs Syndrome, Cerebral Palsy and Other Disabilities.
10. Trust for Americas Health Praises Major Foundations for Supporting Prevention as a Central Part of Health Reform
11. American Humane Association Launches Innovative Therapy Animals Supporting Kids (TASK)(TM) Program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 22, 2014 Losing Weight Your Body’s Way ... staring you in the face, it certainly can be difficult ... your body an extra favor by doing it the healthy ... diets. Instead, listen to your body, exercise regularly, and choose ... essential to losing weight; you need to exercise more and ...
(Date:10/22/2014)... Steven Reinberg HealthDay Reporter , ... add weight and length may be showing a genetic propensity ... adults, certain genes have been linked to increased body fat, ... fat and lean muscle, the researchers said. At 1 ... By ages 2 and 3, however, these genes were linked ...
(Date:10/22/2014)... 2014 (HealthDay News) -- Measures taken by Firestone officials ... Liberia may have limited the spread of the disease ... The Firestone Natural Rubber Co. provides health services to ... nearby densely populated communities. Between Aug. 1 and ... cases among those 80,000 people. That incidence rate of ...
(Date:10/20/2014)... 2014 Allegheny General Hospital’s (AGH) Cardiovascular ... physicians to repair a damaged mitral valve as the ... system, developed by Abbott Vascular , is designed ... life-threatening condition in which the heart’s mitral valve leaflets ... from the heart’s left ventricle into the left atrium. ...
(Date:10/20/2014)... hc1.com today announced the launch ... that enables healthcare organizations of all sizes to ... relationship management (“CRM”) solution. , Designed from the ... the healthcare industry, the hc1 Healthcare Relationship Cloud™ ... by combining healthcare CRM, HIPAA-compliant collaboration, and real-time ...
Breaking Medicine News(10 mins):Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2
... of an emerging mind-body technique that produces measurable changes ... of practice. , The practice -- integrative body-mind training ... the 1990s in China, where it is practiced by ... undergraduates involved in research on the method at the ...
... Purchases Caliper,s Staccato System to Enable High Throughput Research ... Life Sciences, Inc. (Nasdaq: CALP ), a ... and life sciences research, today announced a collaboration with ... Victoria, Australia. PMCC is using Caliper,s Staccato automation system ...
... Support Continued Investment Activity and Growing Group of Health Care ... Partners , a leading private equity firm focused exclusively ... expanded its team with the addition of two health care ... principal and Max Mishkin to vice president. They join ...
... Home Health Equipment business sold in two separate ... reduction, additional working capital to fund DailyMed(TM) growthINDIANAPOLIS, ... KAD ), a leading provider of ... the Arcadia HealthCare(SM) brand, today announced the sale ...
... TSX: COM,VANCOUVER, May 19 /PRNewswire-FirstCall/ ... today announced that the waiting period under the Hart-Scott-Rodino ... & Co., Inc. and a Merck affiliate for development ... treatment of atrial fibrillation, has expired, and the agreement ...
... May 19 MEDai, Inc., headquartered in Orlando, ... healthcare that utilize award-winning predictive analytics, announced today ... D benefit sponsors with the Centers for Medicare ... D to offer members a medication therapy management ...
Cached Medicine News:Health News:Of body and mind, and deep meditation 2Health News:Of body and mind, and deep meditation 3Health News:Peter MacCallum Cancer Centre Expands Cancer Research Efforts with Automation Tool from Caliper Life Sciences 2Health News:Peter MacCallum Cancer Centre Expands Cancer Research Efforts with Automation Tool from Caliper Life Sciences 3Health News:Water Street Healthcare Partners Expands Team With Senior Investment Professionals 2Health News:Water Street Healthcare Partners Expands Team With Senior Investment Professionals 3Health News:Arcadia Resources Announces Sale of Non-Strategic Businesses 2Health News:Arcadia Resources Announces Sale of Non-Strategic Businesses 3Health News:Arcadia Resources Announces Sale of Non-Strategic Businesses 4Health News:Cardiome Announces That Collaboration and License Agreement with Merck & Co., Inc. Now Effective 2Health News:Cardiome Announces That Collaboration and License Agreement with Merck & Co., Inc. Now Effective 3Health News:MEDai Helps Medicare Part D Sponsors Adhere to CMS Medication Therapy Management Initiative 2
(Date:10/22/2014)... 2014  Cephasonics, a technology-innovation leader with a game-changing ... (cQuest Ultrasound Box™-1), the first product in a new ... by Cephasonics for purchase by companies to rebrand with ... be showcasing the cQUB-1 for the first time at ... Chongqing, China from October 23 to ...
(Date:10/22/2014)... HOUSTON , Oct. 22, 2014  Charlene Vernak, RPh, ... York , recently was awarded the George Roentsch ... Vernak received the award in Houston ... The scholarship is awarded annually to an independent pharmacist ... nature of George Roentsch , a well-known pharmacist ...
(Date:10/22/2014)... 2014 A new report by ... type, Form, End user, Application and Geography) - Size, ... Report, Opportunities, Segmentation and Forecast, 2013 - 2020", considers ... on key trends tracked, it is anticipated that the ... by 2020, registering a CAGR of 6.2% from 2014 ...
Breaking Medicine Technology:Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 2Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 3PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4
Implantable medical grade silicone end cap for insulation and sealing protection of 5 mm or 3.2 mm connectors....
...
... Guidant Contak Renewal 3 cardiac ... tachyarrhythmia therapy and cardiac resynchronization ... ventricular (RV) and left ventricular ... to reduce irregular ventricular intervals ...
... housing. MRI-compatible. Requires a guide sphere ... a standard 1.0 - 1.5 cm burr ... assembly with a white collar. MRI-compatible. ... Sterile; single-use only Guide sphere assembly with ...
Medicine Products: