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Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting
Date:11/1/2009

, including Part II, Item 1A. "Risk Factors" in the Company's third quarter 2009 10-Q, filed October 29, 2009.

Endnotes

1. Kwo P, Lawitz E, McCone J, et al. High Sustained Virologic Response in Genotype 1 Null Responders to Peginterferon alfa-2b plus Ribavirin When Treated with Boceprevir Combination Therapy. American Association for the Study of Liver Diseases (AASLD) Annual Meeting; Oct. 30-Nov. 3, Boston, MA, USA; oral presentation, Abstract No. 62.

2. Kwo P, Lawitz E, McCone J, et al. Response-Guided Therapy for Boceprevir Combination Treatment? - Results from HCV SPRINT-1. American Association for the Study of Liver Diseases (AASLD) Annual Meeting; Oct. 30-Nov. 3, Boston, MA, USA; poster presentation, Abstract No. 1582.

3. Kwo P, Lawitz E, McCone J, et al. HCV SPRINT-1 Final Results: SVR 24 from a Phase 2 study of Boceprevir Plus PegIntron (Peginterferon alfa-2b)/Ribavirin in Treatment-Naive Subjects with Genotype 1 Chronic Hepatitis C. 44th European Association for the Study of the Liver (EASL) 2009 Annual Meeting; April 22-26, Copenhagen, Denmark; oral presentation, Abstract No. 4.

4. Intention-To-Treat (ITT) analysis includes any patient who took at least one dose of any study drug.

5. SVR, the protocol specified primary efficacy endpoint, is defined as achievement of undetectable HCV-RNA at 24 weeks after the end of treatment. Per protocol, if a patient did not have a 24-week post-treatment assessment, the patient's 12-week post-treatment assessment was utilized.

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