Navigation Links
Data Show Vaprisol(R) Is Effective & Safe in Promptly Increasing Serum Sodium Levels in Patients With Euvolemic or Hypervolemic Hyponatremia
Date:10/10/2007

sults from a randomized controlled trial (RCT) of 84 patients and an open-label study (OLS) of 251 patients, all with euvolemic or hypervolemic hyponatremia.

After infusion of a 20 mg loading dose or placebo, Vaprisol was given in a continuous 4-day infusion of 40 or 80 mg/d in the RCT and 20 or 40 mg/d in the OLS. The pooled analysis evaluated the frequency of overly rapid [Na+] increases during Vaprisol clinical trials. Note: Overly rapid [Na+] increase can lead to serious neurologic sequelae associated osmotic demyelinization syndrome. This study defined overly rapid increase of serum [Na+] as an increase in serum [Na+] > 12 mEq/L in 24 hours.

In both studies, baseline characteristics were largely similar between those who had an overly rapid increase in [Na+] and those who did not. Among patients who received Vaprisol in the RCT, the mean change in [Na+] was significantly higher compared to the placebo group throughout the 4-day course of treatment. In the OLS, both doses of Vaprisol produced prompt increases that were sustained throughout the 4-day study. The median time to a

confirmed greater than or equal to 4 mEq/L increase in [Na+] was approximately 24 hours in all Vaprisol groups in both studies.

Overall, these two clinical studies demonstrated an overly rapid [Na+] increase in about 5 percent of patients who received Vaprisol for the treatment of hyponatremia. In the RCT, 2 (7 percent) of the 29 patients treated with Vaprisol 40 mg/d, 2 (8 percent) of the 26 treated with Vaprisol 80 mg/d, and 0 of the 29 treated with placebo met the protocol-defined criteria for excessive or overly rapid increase of [Na+]. In the OLS, 1 (3 percent) of 37 patients treated with Vaprisol 20 mg/d and 10 (5 percent) of 214 treated with 40 mg/d met the protocol-defined criteria for excessive or overly rapid increase of [Na+].

None of these patients in either the RCT or the OLS experienced adverse events (AEs) associated with the overly rapid increa
'/>"/>

SOURCE Astellas Pharma US
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Inhaled Steroids Safe & Effective for Children with Asthma
3. Morning after pill effective up to five days after having unprotected sex
4. Distraction therapy found very effective in postoperative patients
5. ZD1839 Proves Effective - A Breakthrough in fighting Lung Cancer
6. TELITHROMYCIN - the proven effective new drug for cap
7. Foods Rich In Flavonoids Effective In Prevention Of Cough
8. Looking Towards More Effective Leukemia Treatment
9. Effectiveness of acupuncture for migraines
10. PA-824 drug effective against Tuberculosis
11. Milk Thistle Not An Effective Cure For Liver Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... Teen substance abuse ranks as one of the most ... adolescents throughout North Carolina struggle with a drug or alcohol ... professional rehab due to a lack of information available to ... Teens Holly Springs is a helpline designed to make a ... abusers in Wake County who are seeking to overcome ...
(Date:8/22/2014)... August 23, 2014 2014 Deep ... a professional and in-depth research report on the ... Meter information, including Glucose Meter definition, classification, application, ... overview. This research covers the international market analysis, ... analysis covering macroeconomic environment & economic situation analysis. ...
(Date:8/22/2014)... Vegas, NV (PRWEB) August 22, 2014 ... email marketing services that currently helps more than ... efforts has caught the attention of Shane Michaels, prompting ... still a crucial element for any online marketing campaign, ... replacing email in the marketing world,” reports Michaels. “AWeber ...
(Date:8/22/2014)... This report studies the "Sample ... Systems), Consumables (Tubes), Kits (Isolation, Purification), By Application ... Global Forecast to 2018" This market was valued ... to grow at a CAGR of 5.9% from ... 2018. , Browse 98 market data Tables and ...
(Date:8/22/2014)... 2014 Millennium Treatment Group has recently noticed ... high level of drug use among teenagers. The treatment facility ... addiction and work to minimize drug abuse. , America is ... drug addiction in history. According to the National Institute ... Americans aged 12 or older—or 9.2 percent of the population—had ...
Breaking Medicine News(10 mins):Health News:New Helpline Provides Teen Drug & Alcohol Recovery Information in Holly Springs, NC 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 3Health News:AWeber: Review Exposes Affordable Provider of Opt-In Email Marketing Services 2Health News:Sample Preparation Market by Product and Application Worth $5,672 Million by 2018 - New Research Report by MarketsandMarkets 2Health News:Sample Preparation Market by Product and Application Worth $5,672 Million by 2018 - New Research Report by MarketsandMarkets 3Health News:Sample Preparation Market by Product and Application Worth $5,672 Million by 2018 - New Research Report by MarketsandMarkets 4Health News:Millennium Treatment Group Sees Increase in Marijuana Use Among Youth 2
... blue lights, are usually most useful on the top of ... Warwick has found a way to use blue light to ... Research led by the University of Warwick, along with ... have found a new light-activated platinum-based compound that is ...
... A new National Research Council report finds no ... through the government,s ground beef purchase program and distributed ... the National School Lunch Program -- would lead to ... Agriculture,s Agricultural Marketing Service (AMS) buys ground beef from ...
... Ind. -- A new study by sexual health researchers ... during sex reported significantly higher levels of satisfaction and ... largest systematic study of this kind, despite the widespread ... concerning its role in alleviating pain or contributing to ...
... 8, 2010) A school-based intervention program helped New ... asthma better manage their symptoms, dramatically reducing the need ... according to a study published online in the ... Students in the eight-week program reported a ...
... Reporter , WEDNESDAY, Dec 8 (HealthDay News) -- A ... pet craves. Over the past five years, sugar has ... cat treats to make them more palatable and profitable, according ... Pet Obesity Prevention. Noting that 90 million U.S. pets ...
... WEDNESDAY, Dec. 8 (HealthDay News) -- If you have ... their accent may help you understand what they,re saying, ... on how well they understood sentences spoken in an ... participants were given different instructions on how to respond ...
Cached Medicine News:Health News:Platinum and blue light combine to combat cancer 2Health News:Stricter testing for federal ground beef program may not lead to safer meat 2Health News:Stricter testing for federal ground beef program may not lead to safer meat 3Health News:Study examines effect of water-based and silicon-based lubricant 2Health News:Study examines effect of water-based and silicon-based lubricant 3Health News:School-based program effective in helping adolescents 2Health News:Those Sweet Pet Treats May Foster Fatness 2Health News:Those Sweet Pet Treats May Foster Fatness 3
(Date:8/21/2014)... 21, 2014 The spinal column is one of ... Signals carried to and from the brain through the column ... system. Injury or ailment here can be life altering, and ... of control over their body. Though back injury and disease ... there are more options available to make things better than ...
(Date:8/21/2014)... , Aug. 21, 2014  Decision Resources ...  physicians in Brazil and ... clinical guidelines and commonly prescribe long-acting beta-agonist (LABA)- ... they do so within current severe cost/coverage constraints. ... that are expected to launch in these countries—which ...
(Date:8/21/2014)... , Aug. 21, 2014  Seventy-one percent of Americans believe ... is a serious public health and safety issue in ... a survey released today by Repass & Partners, a ... "Americans understand the severity of the prescription medication abuse ... with this very serious health situation facing our country," ...
Breaking Medicine Technology:Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3
... Reportlinker.com announces that a new market research ... Insulin Patch Pumps ... inhaled insulin market in 2008 has resulted in ... now appears that the patch pump – a ...
... Reportlinker.com announces that a new market ... The Outlook for Pharmaceuticals ... http://www.reportlinker.com/p0203102/The-Outlook-for-Pharmaceuticals-in-Central-Asia.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=NoCategory These reports provide ... most populous countries in the world and ...
Cached Medicine Technology:Insulin Patch Pumps 2The Outlook for Pharmaceuticals in Central Asia 2The Outlook for Pharmaceuticals in Central Asia 3The Outlook for Pharmaceuticals in Central Asia 4
... of Topics Covered: diagrams, full ... and differentials of a multitude ... vision loss, pupillary abnormalities, glaucoma, ... medications, cataracts, vision correction surgery, ...
... all those involved with healthcare decisions to ... latest evidence in their field of interest ... year as the volume of evidence increases. ... the best single source available for continually ...
Muscles Anatomy Flash Cards uses the time tested content and images from BryanEdwards.com....
The ideal on-the-spot reference for residents and practitioners seeking fast facts on fracture management....
Medicine Products: