Navigation Links
Data Show Vaprisol(R) Is Effective & Safe in Promptly Increasing Serum Sodium Levels in Patients With Euvolemic or Hypervolemic Hyponatremia
Date:10/10/2007

sults from a randomized controlled trial (RCT) of 84 patients and an open-label study (OLS) of 251 patients, all with euvolemic or hypervolemic hyponatremia.

After infusion of a 20 mg loading dose or placebo, Vaprisol was given in a continuous 4-day infusion of 40 or 80 mg/d in the RCT and 20 or 40 mg/d in the OLS. The pooled analysis evaluated the frequency of overly rapid [Na+] increases during Vaprisol clinical trials. Note: Overly rapid [Na+] increase can lead to serious neurologic sequelae associated osmotic demyelinization syndrome. This study defined overly rapid increase of serum [Na+] as an increase in serum [Na+] > 12 mEq/L in 24 hours.

In both studies, baseline characteristics were largely similar between those who had an overly rapid increase in [Na+] and those who did not. Among patients who received Vaprisol in the RCT, the mean change in [Na+] was significantly higher compared to the placebo group throughout the 4-day course of treatment. In the OLS, both doses of Vaprisol produced prompt increases that were sustained throughout the 4-day study. The median time to a

confirmed greater than or equal to 4 mEq/L increase in [Na+] was approximately 24 hours in all Vaprisol groups in both studies.

Overall, these two clinical studies demonstrated an overly rapid [Na+] increase in about 5 percent of patients who received Vaprisol for the treatment of hyponatremia. In the RCT, 2 (7 percent) of the 29 patients treated with Vaprisol 40 mg/d, 2 (8 percent) of the 26 treated with Vaprisol 80 mg/d, and 0 of the 29 treated with placebo met the protocol-defined criteria for excessive or overly rapid increase of [Na+]. In the OLS, 1 (3 percent) of 37 patients treated with Vaprisol 20 mg/d and 10 (5 percent) of 214 treated with 40 mg/d met the protocol-defined criteria for excessive or overly rapid increase of [Na+].

None of these patients in either the RCT or the OLS experienced adverse events (AEs) associated with the overly rapid increa
'/>"/>

SOURCE Astellas Pharma US
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Inhaled Steroids Safe & Effective for Children with Asthma
3. Morning after pill effective up to five days after having unprotected sex
4. Distraction therapy found very effective in postoperative patients
5. ZD1839 Proves Effective - A Breakthrough in fighting Lung Cancer
6. TELITHROMYCIN - the proven effective new drug for cap
7. Foods Rich In Flavonoids Effective In Prevention Of Cough
8. Looking Towards More Effective Leukemia Treatment
9. Effectiveness of acupuncture for migraines
10. PA-824 drug effective against Tuberculosis
11. Milk Thistle Not An Effective Cure For Liver Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2015)... ... August 31, 2015 , ... Negotiating an FDA Import Hold Crisis:, Strategies ... p.m. EDT, http://www.fdanews.com/importholdcrisis , US authorities are holding imports more than ever ... India. , With alerts on an uptick and a new final rule, having a ...
(Date:8/30/2015)... ... August 31, 2015 , ... ChopChop Kids, the nonprofit publisher ... recently elected two new officers to serve on the organization’s Board of Directors ... and teaching kids to cook real food with their families and help continue ...
(Date:8/30/2015)... ... August 30, 2015 , ... ... to announce that Partner Daniel M. Kotin was recently elected to membership in ... constitutes the highest degree of peer recognition and outstanding professionalism. , ABOTA ...
(Date:8/30/2015)... ... August 30, 2015 , ... Lizzie’s Lice Pickers , a company ... The company is currently offering lice head checks for just $10, which is a ... a 10% discount on their lice treatment products. “With kids returning to school, it ...
(Date:8/30/2015)... ... August 30, 2015 , ... InHealth Media ( http://www.inhealthmedia.com ) ... Communications Director for InHealth Media. Mr. Spector comes with a wide array ... doing on-air television, producing shows, on air-radio and media relations. , Brian ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces — Negotiating an FDA Import Hold Crisis: Strategies for Challenging FDA Findings Webinar, Sept. 22, 2015 2Health News:FDAnews Announces — Negotiating an FDA Import Hold Crisis: Strategies for Challenging FDA Findings Webinar, Sept. 22, 2015 3Health News:ChopChop Kids Appoints New Chair and Vice-Chair to Board of Directors 2Health News:ChopChop Kids Appoints New Chair and Vice-Chair to Board of Directors 3Health News:Chicago Personal Injury Lawyer Daniel M. Kotin Elected to the American Board of Trial Advocates 2Health News:Chicago Personal Injury Lawyer Daniel M. Kotin Elected to the American Board of Trial Advocates 3Health News:Lizzie’s Lice Pickers Announces Back to School Head Check Special and Discounted Lice Treatment Products 2Health News:InHealth Media Appoints New Global Communications Director 2
... http://www.minuteclinic.com ), the pioneer and largest provider ... announced that it has become a,participating provider ... national provider of individual medical,small group and ... a MinuteClinic health care center, members enrolled ...
... Ltd., the biomedical,research group and developer of the ... Exempla Healthcare has contracted to utilize QDS,internet Quality ... QDS automates the gap between donor registration ... utilizes audio-visual touch screen computer,assisted donor self interviewing ...
... war on asthma symptom control could be a psychological one, ... and Dads leeriness towards their childrens asthma medications simply ... that outweigh the benefits might explain to some extent ... the wheezing, coughing and trouble-breathing disease do not take their ...
... by UT Southwestern Medical Center researchers has found that overweight ... high risk for iron deficiency. , Based on data ... that 20 percent of overweight toddlers were iron-deficient, compared to ... 7 percent of normal-weight toddlers. , The study, appearing ...
... weeks press release: , , Renal function and coronary ... mice by mesenchymal stem cells overexpressing angiopoietin 1, , , ... the links below to take your readers straight to ... ARTICLES WILL BE PUBLISHED ONLINE: , , Renal function and ...
... 28 at 11 a.m. in Nashville, NASHVILLE, ... leaders from Tennessee will hold a press conference ... granting the U.S.,Food and Drug Administration (FDA) authority ... entire Tennessee Congressional Delegation,particularly U.S. Representatives Bart Gordon ...
Cached Medicine News:Health News:MinuteClinic Becomes Participating Provider with Assurant Health 2Health News:MinuteClinic Becomes Participating Provider with Assurant Health 3Health News:Exempla Healthcare Contracts For Talisman's Quality Donor System 2Health News:Parents' perceptions can hamper kids' asthma care, study finds 2Health News:Parents' perceptions can hamper kids' asthma care, study finds 3Health News:Overweight toddlers and those not in day care at risk for iron deficiency 2Health News:Overweight toddlers and those not in day care at risk for iron deficiency 3Health News:Renal function and heart disease, and more 2Health News:Tennessee Faith Leaders Call on Reps. Gordon & Blackburn to Co-sponsor Legislation to Protect Kids from Tobacco 2
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015 ... has announced the addition of the "Investigation ... report to their offering. Developed by ... of Novolog) is an important drug for the ... aspart, as a fast- acting insulin analog, starts ...
(Date:8/28/2015)... 2015  IP Shakti, LLC, today announced that it has ... Logo - http://photos.prnewswire.com/prnh/20150827/261551LOGO ... corporate identity signifies our transformation into a company focused on ... for patent claim validity." ... AIA Shield™ platform, the Company commenced a corporate re-branding initiative ...
(Date:8/28/2015)... and PITTSBURGH , ... MYL ) today announced that its shareholders have ... (NYSE: PRGO ; TASE) and the related ... at an extraordinary general meeting of shareholders held ... votes cast at the extraordinary general meeting. In ...
Breaking Medicine Technology:China Insulin Aspart Market Report 2010-2019 - Developed by Novo Nordisk 2IP Shakti, LLC Changes Company Name to Prediqtus, LLC 2Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 2Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 3Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 4Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 5Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 6Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 7Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 8Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 9
... FRANCISCO, Calif., Feb. 9, 2011 Rigel Pharmaceuticals, Inc. ... M. Gower, the company,s chairman and chief executive officer, ... New York City next week. Details of the events ... Annual BIO CEO & Investor ConferencePanel Topic:  "Rheumatoid Arthritis: ...
... Labs, Inc. (OTC Bulletin Board: GOVX), a ... vaccines, announced today the opening of a second clinical ... of the University of Alabama at Birmingham (UAB) to ... GeoVax vaccines are currently being tested clinically for HIV ...
Cached Medicine Technology:Rigel Announces Participation at Two Investor Conferences 2GeoVax Launches a Second Clinical Site to Test the Therapeutic Benefit of its HIV Vaccine 2GeoVax Launches a Second Clinical Site to Test the Therapeutic Benefit of its HIV Vaccine 3
... Single Use linear stapler with LACTOMER™ ... Suture™ PREMIUM POLY CS™-57 disposable surgical ... of a temporary opening, such as ... section, or when transecting muscle tissue, ...
... Units With Titanium Staples for ... (Single Use Reloadable Stapler with ... Suture™ PREMIUM MULTIFIRE TA™ stapler ... pediatric and thoracic surgical procedures ...
... Single Use Loading Units for ... (Single Use Reloadable Staplers with ... Suture™ TA™ Reloadable staplers has ... and thoracic surgical procedures for ...
... linear stapler for resection, transection and anastomosis ... MULTIFIRE GIA™ 60 and 80 single use ... 80 single use loading units and the ... use surgical stapler with MULTIFIRE SGIA™ 60 ...
Medicine Products: