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Data Show Dutasteride Reduces Prostate Cancer Diagnosis in Men With Increased Risk
Date:4/28/2009

REDUCE Trial data presented during American Urological Association Annual Meeting, April 27

CHICAGO, April 28 /PRNewswire-USNewswire/ -- Dutasteride (Avodart), a commonly prescribed drug to treat benign prostatic hyperplasia, has been shown to lower the risk of prostate cancer by 23 percent in men with an increased risk of the disease, according to results of an international clinical trial presented yesterday at the American Urological Association (AUA) Annual Meeting in Chicago. Data from the REDUCE Trial was presented to members during the plenary session, and lead investigator Gerald Andriole, MD, of Washington University School of Medicine in St. Louis, held a special session for interested media at 12:15 p.m. in the AUA Press Suite.

The REDUCE trial is the first to examine chemoprevention for prostate cancer in men at increased risk for the disease. The trial involved 8,200 men ages 50 - 75 who were randomly assigned to receive a placebo or a daily 0.5 mg dose of dutasteride. Men in the study had elevated PSA levels (2.5 - 10 ng/ml) indicating that they were at increased risk of prostate cancer. They had undergone biopsies that found no evidence of cancer within six months prior to enrolling in the trial. Therefore these men either did not have prostate cancer or possibly had microscopic tumors that were too small to be detected by the pre-study biopsy.

The investigators performed scheduled biopsies on the men two years after they enrolled in the study and again after four years. After two years, prostate cancer was found in 17.2 percent of the men who took a placebo, compared with 13.4 percent who took dutasteride. After four years, prostate cancer was diagnosed in another 11.8 percent of men who received a placebo and 9.1 percent who received dutasteride.

"In these men, the most likely explanation is that dutasteride worked by shrinking tumors and/or slowing t
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SOURCE American Urological Association
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