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Data Show Common Allergy Tests Are Not Interchangeable
Date:5/8/2008

ion of America)) and 3gAllergy Universal Module (Siemens' Immulite(R) system). The tests measured specific IgE levels in 50 patients for egg, milk, peanut, cat, birch and dust mite. The results revealed significant differences among the three tests in the measurement of allergen-specific IgE levels, which can impact the clinical decision-making process.

When quantitative evaluation was performed, the Turbo-MP overestimated IgE levels for egg but underestimated levels for dust mite and birch pollen. Differences also were found between Turbo-MP and ImmunoCAP for milk, peanut and cat. The 3gAllergy Universal Module overestimated all allergen-specific IgE levels compared with ImmunoCAP.

"Results from these tests are used to guide treatment decisions, and variability around the decision points can alter clinical management of a suspected allergy," concluded the study authors. "Food allergen avoidance on the basis of inconsistent laboratory results can have profound nutritional and social implications and can significantly affect a child and the child's family's quality of life."

Another study published in the Annals of Allergy, Asthma & Immunology in July 2007 demonstrated that the ImmunoCAP Specific IgE system was directly traceable to the World Health Organization (WHO) standard preparation for total IgE in the detection of quantitative specific IgE antibodies. This traceability to the WHO standard was not equally demonstrated with the Turbo-RAST and 3gAllergy Universal Module specific IgE assays. The study was the first of its kind to compare specific IgE results of different technologies as measured against an independently verified IgE standard.

"These studies further validate ImmunoCAP's overall performance as compared to other specific IgE allergy blood tests, making it a valuable option in the management of allergic disorders," said Michael Land, president and general manager, Phadia U.S. Inc. "Physicians and patients need to be aware
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SOURCE Phadia U.S. Inc
Copyright©2008 PR Newswire.
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