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Data Show ARIMIDEX(R) (Anastrozole) Continues To Be Superior to Tamoxifen in Helping Reduce the Risk of Recurrence in Patients With Early Breast Cancer
Date:12/14/2007

Effectiveness Of ARIMIDEX Still Evident More Than Three Years After

Treatment

SAN ANTONIO, Texas, Dec. 14 /PRNewswire-FirstCall/ -- Data released today show a continued benefit of ARIMIDEX when compared to tamoxifen in treating postmenopausal women with hormone receptor-positive (HR+) early breast cancer. Results of the ATAC (ARIMIDEX, Tamoxifen, Alone or in Combination) trial, reported today at the 2007 San Antonio Breast Cancer Symposium, represent a median follow-up of more than eight years and show an absolute reduction in the risk of recurrence and distant recurrence with ARIMIDEX. The ATAC trial is one of the world's longest and largest breast cancer studies and is supported by AstraZeneca.

With approximately 2.5 million breast cancer survivors in the United States today, the ATAC 100-month analysis marks a major milestone in understanding the treatment of HR+ early breast cancer(1). The data show that the effects of ARIMIDEX in decreasing the risk of recurrence compared with tamoxifen continue even after patients have completed therapy.

At a median follow-up of 100 months, more than three years after the completion of treatment, ARIMIDEX significantly reduces the risk of recurrence in comparison with tamoxifen in postmenopausal patients with HR+ breast cancer. A significant benefit of ARIMIDEX on distant recurrence is now evident (HR+population p=0.027), and ARIMIDEX is also shown to reduce the risk of distant metastases. Although there was no difference in overall survival, the impact of ARIMIDEX at reducing distant metastases is important, as distant recurrence-free survival is an important predictor for survival related to breast cancer(2).

"The long-term data from the ATAC trial continue to impact the way physicians worldwide treat postmenopausal women with hormone receptor-positive early breast cancer," said Aman U. Buzdar, MD, who represents North America on the ATAC Steering Committe
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SOURCE AstraZeneca
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