Navigation Links
Data Show ARIMIDEX(R) (Anastrozole) Continues To Be Superior to Tamoxifen in Helping Reduce the Risk of Recurrence in Patients With Early Breast Cancer

Effectiveness Of ARIMIDEX Still Evident More Than Three Years After


SAN ANTONIO, Texas, Dec. 14 /PRNewswire-FirstCall/ -- Data released today show a continued benefit of ARIMIDEX when compared to tamoxifen in treating postmenopausal women with hormone receptor-positive (HR+) early breast cancer. Results of the ATAC (ARIMIDEX, Tamoxifen, Alone or in Combination) trial, reported today at the 2007 San Antonio Breast Cancer Symposium, represent a median follow-up of more than eight years and show an absolute reduction in the risk of recurrence and distant recurrence with ARIMIDEX. The ATAC trial is one of the world's longest and largest breast cancer studies and is supported by AstraZeneca.

With approximately 2.5 million breast cancer survivors in the United States today, the ATAC 100-month analysis marks a major milestone in understanding the treatment of HR+ early breast cancer(1). The data show that the effects of ARIMIDEX in decreasing the risk of recurrence compared with tamoxifen continue even after patients have completed therapy.

At a median follow-up of 100 months, more than three years after the completion of treatment, ARIMIDEX significantly reduces the risk of recurrence in comparison with tamoxifen in postmenopausal patients with HR+ breast cancer. A significant benefit of ARIMIDEX on distant recurrence is now evident (HR+population p=0.027), and ARIMIDEX is also shown to reduce the risk of distant metastases. Although there was no difference in overall survival, the impact of ARIMIDEX at reducing distant metastases is important, as distant recurrence-free survival is an important predictor for survival related to breast cancer(2).

"The long-term data from the ATAC trial continue to impact the way physicians worldwide treat postmenopausal women with hormone receptor-positive early breast cancer," said Aman U. Buzdar, MD, who represents North America on the ATAC Steering Committee and is the principle investigator for the trial in the United States. "ARIMIDEX has been shown to be significantly superior to tamoxifen in terms of disease-free survival, time to recurrence, time to distant metastases and contralateral breast cancer."

The ATAC trial is one of the largest studies evaluating five years of primary adjuvant therapy with an aromatase inhibitor (AI).

The availability of 100 months of follow-up data is also providing long- term information on the safety profile of five years of treatment with ARIMIDEX. During the treatment period, ARIMIDEX was associated with an increased incidence of joint symptoms and fractures (10 percent versus 7 percent). However, the 100-month analysis showed that fracture rates decreased after completion of treatment and were similar in both treatment arms.


Prescription ARIMIDEX is only for postmenopausal women. ARIMIDEX should not be taken if you are pregnant because it may harm your unborn child.

In the early breast cancer clinical trial, the most common side effects seen with ARIMIDEX include hot flashes, joint symptoms, weakness, mood changes, pain, sore throat, nausea and vomiting, depression, high blood pressure, osteoporosis, swelling of arms/legs, and headache. Fractures (including fractures of the spine, hip, and wrist) occurred more frequently with ARIMIDEX than with tamoxifen (10 percent versus 7 percent).

ARIMIDEX should not be taken with tamoxifen or estrogen-containing therapies.

For more information, please see ARIMIDEX full Prescribing Information available at

About AstraZeneca

AstraZeneca (NYSE: AZN) is a major international health care business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of health care services. It is one of the world's leading pharmaceutical companies with health care sales of $26.47 billion and leading positions in sales of gastrointestinal, cardiovascular, neuroscience, respiratory, oncology and infection products. AstraZeneca is listed in the Dow Jones Sustainability Index (Global) as well as the FTSE4Good Index.

In the United States, AstraZeneca is a $12.44 billion health care business with more than 12,000 employees. For nearly three decades, AstraZeneca has offered drug assistance programs side by side with its medicines, and over the past five years, has provided over three billion in savings to more than one million patients throughout the U.S. and Puerto Rico. AstraZeneca has been named one of the "100 Best Companies for Working Mothers" by Working Mother magazine and is the only large pharmaceutical company named to FORTUNE magazine's 2007 list of "100 Best Companies to Work For." In 2006, for the fifth consecutive year, Science magazine named AstraZeneca a "Top Employer" on its ranking of the world's most respected biopharmaceutical employers.

For more information about AstraZeneca, please visit: http://www.astrazeneca-

ARIMIDEX is a registered trademark of the AstraZeneca group of companies.

(1) American Cancer Society. What Are the Key Statistics for Breast

Cancer? tatisti

cs_for_breast_cancer_5.asp (Due to the length of the URL, please copy and paste URL into browser to view.) Accessed 10/31/2007.

(2) Del Mastro et al. Reducing the risk of distant metastases in breast

cancer patients: role of aromatase inhibitors.

Cancer Treatment Rev 2007 In Press.

SOURCE AstraZeneca
Copyright©2007 PR Newswire.
All rights reserved

Related medicine news :

1. AstraZeneca Receives Six Months Pediatric Exclusivity Patent Extension for ARIMIDEX(R) (anastrozole) from the FDA
2. Battle Continues Over Vietnam PTSD Numbers
3. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
4. Therap Services Continues to Hire Experienced Developmental Disability Industry Clinicians for its Customer Support Team
5. Securians Minnesota Life Continues to Climb Group Life Rankings
6. USA TODAY Continues Spirit of the USA Charity Program as Part of Newspapers 25th Anniversary Celebration
7. United States continues to have highest level of health spending
8. LehmanMillet Continues Expansion with Strategic Hires
9. American Cancer Society report finds breast cancer death rate continues to drop
10. CIGNA HealthCare Continues Gains in Health Care Quality
11. Los Angeles Jewish Home Support Group Continues High-Profile Speaker Program With Noted Legal Scholar and Expert Laurie L. Levenson
Post Your Comments:
(Date:10/10/2015)... ... ... Isabel Healthcare will participate in the Cerner Health Conference October 11-14, 2015 ... Institute of Medicine’s latest report “Improving Diagnosis in Healthcare”, Isabel Healthcare will be featuring ... and consumers to potentially reduce the chance of error. The report suggests that most ...
(Date:10/9/2015)... ... October 09, 2015 , ... The American Osteopathic Foundation ... Graduate Medical Education J. Michael Finley, DO, as the recipient of the 2015 ... his impact on graduate medical education opportunities for osteopathic residents, and his dedication ...
(Date:10/9/2015)... ... ... A new health tool that helps identify if a sore throat is ... – just in time for the cold and flu season, which the Center for ... the U.S., the real start of cold/flu season is the start of the school ...
(Date:10/9/2015)... ... October 09, 2015 , ... Dentist in Huntington Beach ... system that uses clear, plastic aligners. This alternative to braces has become wildly ... allow patients to complete treatment in privacy. Additionally, Invisalign aligners are removable, so ...
(Date:10/9/2015)... (PRWEB) , ... October 09, 2015 , ... The Asthma ... the US Centers for Disease Control and Prevention (CDC) to improve the knowledge and ... that AAFA has been awarded a project by the CDC and allows AAFA to ...
Breaking Medicine News(10 mins):
... better diagnosis and drug treatments, study says , , WEDNESDAY, ... most common form of mental retardation -- called nonsyndromic ... that may contribute to the condition, new research finds. ... occurs during development of the child and is not ...
... virus strikes healthy kids, and it affects more youngsters than ... It,s called respiratory syncytial virus (RSV), a childhood infection that,s ... and one of every 38 emergency room trips, a new ... for inpatient hospital stays for one out of every 334 ...
... is a statement by Matthew L. Myers, President, ... and President Obama today are delivering a historic ... increasing federal tobacco taxes, including a 62-cent increase ... Children,s Health Insurance Program (SCHIP). This legislation ...
... Feb. 4 , WHAT: , ... event, with members of the cast,of Broadway,s Tony Award-winning best ... February 6, 2009 , WHO: , ... compelling stories of women making,heart-healthy choices and inspiring others with ...
... seeks new ways to prevent and treat chronic diseases such ... be conducted on the benefits of certain foods in reducing ... often cited as being high in antioxidants, which have the ... within the body, reducing the risk of cancer and other ...
... Feb. 4 Erik Olson, director of chemical and food ... the following statement today in response to the introduction of ... , , "In the midst of ... Safety Modernization Act (FSMA) could not be more timely. The ...
Cached Medicine News:
(Date:10/9/2015)... , October 9, 2015 ... die sich einer Kolonoskopie im Rahmen eines ... unterziehen. Die NOCT-Studie bewertete auch die Compliance, ... --> ® ) an erwachsenen Patienten ... eines Screenings, einer beobachtenden oder einer diagnostischen ...
(Date:10/9/2015)... , October 9, 2015 ... (OTCQB: CNBX) has announced its execution of an Intellectual Property ... Liabilities Agreement with Cannabics, Inc. a Delaware Corporation, related party, ... --> --> These ... of the Company, whereby the Research and Development components ...
(Date:10/9/2015)... India , October 9, 2015 ... --> The report ... market and overall status of the ... of guidance and direction for companies ... . ...
Breaking Medicine Technology:
... PRO-DEX, INC. (Nasdaq: PDEX ) invites investors and ... fiscal 2012 first quarter financial results. (Logo:   ... be broadcast live over the internet on Wednesday, November 9, ... and may be accessed by visiting the Company,s website at ...
... VIEW, Calif., Nov. 3, 2011 VIVUS, Inc. (NASDAQ: ... were published in Obesity, the peer-reviewed journal of The ... the investigational drug Qnexa in 1,267 severely obese (BMI >/= 35 ... addition to average weight loss of 14.4% of initial body weight ...
Cached Medicine Technology:
2.5V Halogen source, fiber-optic delivery, 2.5X magnification....
Pocket-sized instrument with 2.5X magnification....
Pocket-sized instrument. All Keeler otoscopes have bright halogen illumination for clear and accurate visualization of aural canal. Lithium-ion batteries with quick recharge capability. Ring rheos...
Otoscope with 4X magnification lens, swivellable to both sides, with removable cover glass to insert external instruments. Sealed system allowing for pneumatic otoscopy. 2.5V halogen source....
Medicine Products: