SAN MATEO, Calif., Feb. 7 /PRNewswire/ -- Anthera Pharmaceuticals, Inc., a privately held biopharmaceutical company developing anti-inflammatory drugs, announced today that data from the Phase II trial of its novel secretory phospholipaseA2 inhibitor Varespladib (A-002) for the treatment of coronary heart disease will be presented as a late breaker at the 2008 American College of Cardiology 57th Annual Scientific Session on Monday, March 31, 2008 in Chicago, Illinois.
The Phase II trial known as PLASMA (Phospholipase Levels And
Serological Markers of Atherosclerosis) was a multi-center, randomized,
double-blind, placebo-controlled trial that enrolled approximately 400
patients with stable coronary heart disease in the U.S. and Ukraine.
Subjects were randomized to receive one of four different doses of A-002 or
placebo for up to eight weeks. Patients also received doctor-determined
standard of care therapies. The primary endpoint was a reduction in
secretory phospholipase A2 (sPLA2). The study also evaluated the effect of
Varespladib on cholesterol levels (LDL-C, non-HDL and total cholesterol) as
well as inflammation in patients with stable coronary heart disease.
PLASMA Late-Breaker Trial Data Presentation:
Date/Time: Monday, March 31 from 2:30-2:45pm.
Title/Author: Effects of a Selective Inhibitor of Secretory
Phospholipase A2 on Low Density Lipoproteins and Inflammatory Pathways,
Robert S. Rosenson, MD, Director, Lipoprotein Disorders and Clinical
Atherosclerosis Research, Division of Cardiovascular Medicine at the
University of Michigan, for the PLASMA Investigators.
Location: McCormick Place, Vista Room S406
About Anthera Pharmaceuticals
Anthera Pharmaceuticals is a privately-held company committed to
developing and commercializing clinical pharmaceutical products that
address unmet medical needs of patients with life-threatening, chronic and
acute inflammatory diseases and a
|SOURCE Anthera Pharmaceuticals, Inc.|
Copyright©2008 PR Newswire.
All rights reserved