Navigation Links
Dasatinib, Nilotinib show strong early results as frontline therapy for chronic myelogenous leukemia
Date:12/9/2007

percent at three months, 54 percent at six months and 65 percent at a year. For high-dose imatinib the historical response rates were 62 percent, 82 percent and 86 percent.

As frontline treatment, imatinib has increased the 5-year survival rate for CML patients from 50 percent to 90 percent. Imatinib targets the aberrant Bcr-Abl protein, caused by a chromosomal abnormality called the Philadelphia Chromosome, which fuels an overabundance of white blood cells and immature stem cells called blasts that crowd out red blood cells and platelets.

Nilotinib and Dasatinib target a greater variety of genetic variations leading to CML than does imatinib.

Both clinical trials continue to enroll patients. Side effects are being closely monitored and some patients in each trial had their doses reduced or treatment temporarily interrupted to deal with toxicities. "We can't say at this moment that either drug has major problems with side effects," Cortes said.

The trials tap M. D. Anderson's longstanding expertise in all three drugs. M. D. Anderson was a leader in the registration clinical trial that led to approval of imatinib for CML.

"As some of our patients started to develop resistance to imatinib, we started searching for agents to bypass that resistance, working with the pharmaceutical companies to test new agents," says Hagop Kantarjian, M.D., chair of M. D. Anderson's Department of Leukemia.

Kantarjian developed, designed and conducted the clinical trials that led to approval of nilotinib by the FDA last month for patients who can no longer take imatinib.

Moshe Talpaz, M.D., developed, designed and conducted clinical trials that led to approval of dasatinib by the FDA in June 2007 for the same group of patients. Talpaz is now at the University of Michigan.

Cortes is leading research into a third drug, bosutinib, produced by Wyeth Pharmaceuticals, as a second-line therapy for CML. (Please see separate n
'/>"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Smoking may strongly increase long-term risk of eye disease
2. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
3. Family History Has Strong Effect on Cardiac Risk
4. Allied Healthcare Reports Strong Fourth Quarter, Flat Net Income for Fiscal 2007 vs. 2006
5. New Jersey Physicians Launch New, Statewide Association to Fight for Stronger Voice in Healthcare
6. Dynatronics Announces Strong Fourth Quarter Profit
7. New Survey Finds Strong Public Interest in Prescription Drug Safety Issues
8. Audio: New Survey Finds Strong Public Interest in Prescription Drug Safety Issues
9. Armstrong Kids Get in Step with Good Health
10. Chubby Checker Adds Twist to 10,000 Strong at Ninth Annual Walk to Cure Cancer for UMass Memorial Cancer Center at the UMass Medical School
11. Produce for Better Health Foundation Releases Statement on Study Saying Fruit & Vegetable Consumption Not Strongly Associated With Colon Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... ... Thule Atmos X4 offers protection with minimal bulk. At the Thule Test Center™, ... Due to its Bi-ComponentArmor and ShockStop corners, it passed Thule’s 2 meter drop test, ... The Thule Atmos X4 has also been designed with function in mind. The ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... Nutritional Products ... of nutritional and beauty products, recently attended the 2015 ECRM Diet, Vitamin & Sports ... in the retail industry. The ECRM trade show allows companies the chance ...
(Date:7/1/2015)... ... July 01, 2015 , ... First Harvest ... a web-based resource where legal cannabis startups can interact with corporate ... and medical marijuana advocates looking to strategically enter and capitalize on growing and ...
(Date:7/1/2015)... and Copiague, NY (PRWEB) , ... July 01, ... ... provider of physical therapy and rehabilitation clinics throughout New York and New Jersey, ... York, incorporating it into its portfolio of state-of-the-art clinics. At this most recent ...
(Date:6/30/2015)... (PRWEB) , ... June 30, 2015 , ... ... specializes in Middle eastern, Persian and Mediterranean foods and groceries. Persianbazzar.com has recently ... time for the BBQ season, http://persianbazzar.com added great product lines such ...
Breaking Medicine News(10 mins):Health News:NPI Meets With Top Retail Figures at ECRM Conference 2Health News:First Harvest Financial Partners in Launch of Legal Medical Cannabis Documentary Initiative 2Health News:First Harvest Financial Partners in Launch of Legal Medical Cannabis Documentary Initiative 3Health News:Professional Physical Therapy Acquires Copiague’s South Bay Sports & Physical Therapy, P.C. 2Health News:Persian Bazzar Now Announces the Addition of Golden Star Food and Kitchenware to their website. 2Health News:Persian Bazzar Now Announces the Addition of Golden Star Food and Kitchenware to their website. 3
... More than one in four elderly Americans lacked the capacity ... life, according to a study of 3,746 people to be published ... Those who had advance directives - including living wills or ... wanted most of the time, says lead author Maria Silveira, M.D., ...
... Guidelines based on national data point to those heart ... News) -- Who,s most at risk when undergoing the ... U.S. study may have come up with some answers ... the odds of death after angioplasty, also known as ...
... Orange, Calif., March 31, 2010 UC Irvine ... Center have again earned the Gold Seal of ... and accrediting body. Joint Commission certification recognizes ... accepted nationwide as benchmarks for superior patient care. ...
... ... , ... 31, 2010 -- Pat Heyward Canes, a new provider of fashion forward walking canes ... and women ranging from classic to whimsical. Made from performance materials, the canes can ...
... genetic blueprint for humans , WEDNESDAY, March 31 (HealthDay News) ... scientists muse on how far they,ve come and how far ... of the genome draft in 2001 permanently altered the scientific ... to come, according to scientists writing in the April 1 ...
... ... the world to AMD Alliance International,s first global film competition aimed at raising awareness of ... world for people over 50. AMD Alliance International (AMDAI) announced the winners of the contest ... (PRWEB) March ...
Cached Medicine News:Health News:More than one-quarter of elderly patients lack decision-making capacity at death 2Health News:More than one-quarter of elderly patients lack decision-making capacity at death 3Health News:New Insights Into Who's At Risk With Angioplasty 2Health News:New Insights Into Who's At Risk With Angioplasty 3Health News:Medical center's heart failure, stroke programs recertified by Joint Commission 2Health News:Pat Heyward Canes Unveils New Stylish Walking Cane Collection Just in Time for Mother's Day 2Health News:Human Genome Turns 10 2Health News:Human Genome Turns 10 3Health News:Winners Announced from AMD Alliance International Film Contest 2Health News:Winners Announced from AMD Alliance International Film Contest 3Health News:Winners Announced from AMD Alliance International Film Contest 4
(Date:6/30/2015)... FREMONT, Calif. , June 30, 2015 ... and specialty medicine, continues to grow and add customers ... than 40% of the 62 CTSAs awarded by the ... clinical research information management. This is among the largest ... "Our presence in the CTSA community keeps growing ...
(Date:6/30/2015)... way for people to keep their family safe, while also ... being introduced to the world via an Indiegogo crowdfunding ... which needs to be raised in order to bring the ... was inspired by the many scenarios people face in their ... While medical alert bracelets have been around for years, they ...
(Date:6/30/2015)... -- A new report released today from the Institute of ... and training opportunities to reduce barriers to the provision ... rates of CPR and AED use by bystanders remain ... States even though evidence indicates that its ... Cross strongly supports the IOM,s recommendation to encourage training ...
Breaking Medicine Technology:Velos continues adding CTSA customers - 40% now use Velos products 2Amyko Propels Medical Alert Bracelets Into the Modern Era 2New Recommendations in Cardiac Arrest Protocol Advocate for Increased CPR and AED Training to Improve U.S. Survival Rates 2New Recommendations in Cardiac Arrest Protocol Advocate for Increased CPR and AED Training to Improve U.S. Survival Rates 3New Recommendations in Cardiac Arrest Protocol Advocate for Increased CPR and AED Training to Improve U.S. Survival Rates 4
... Inc. announced today that it has received FDA 510(k) clearance ... Generator powers the Stretta® System for treatment of Gastroesophageal Reflux ... Incontinence or Bowel Control Disorder (BCD). "Today,s ... investment and design efforts by Mederi. The goal of the ...
... ClinOps is a specialized contract research organization with ... biostatistics and specialized clinical services. Emphusion targets development ... when these services are a key to success. ... effective immediately. "Through acquisition and internal ...
Cached Medicine Technology:Mederi Therapeutics Announces Receipt of FDA 510(k) Clearance for the MDRF1 Radiofrequency Generator 2ClinOps to Change Name to Emphusion 2
... The SC-Acufix anterior cervical plate system ... a patented, integrated swivel, which provides for ... and prevents bone screw disengagement or backout. ... a secondary locking screw. Simply implant your ...
Relocatable frame has been designed specifically for fractionated stereotactic radiotherapy treatments. It provides a fast, non-invasive and reproducible fixation of the patient....
... consisting of one part only, is made of ... compressed Polyamide may be rotated and moved as ... sizes and shapes, as well. Moreover they secure ... in caudal direction, which is one of the ...
VG1 ALIF (Anterior) Anterior lumbar interbody fusion. Frozen freeze-dried preservation....
Medicine Products: