Navigation Links
Dasatinib, Nilotinib show strong early results as frontline therapy for chronic myelogenous leukemia
Date:12/9/2007

ATLANTA - Two drugs approved for use as second line therapy for chronic myelogenous leukemia are showing promising results as frontline therapy for newly diagnosed patients in two clinical trials, research teams led by scientists at The University of Texas M. D. Anderson Cancer Center report at the 49th annual meeting of the American Society of Hematology.

All patients in both trials have a complete cytogenetic response - absence of the aberrant chromosome that causes the disease - after one year on either drug. Approximately 90 percent reach complete cytogenetic response as early as 6 months.

"These are early results but certainly encouraging so far in both cases," says lead author Jorge Cortes, M.D., professor in M. D. Anderson's Department of Leukemia. Patients in both trials are in the chronic, or initial phase, of CML and had not received prior therapy for their disease.

The two medications are dasatinib, the Bristol-Myers Squibb drug known as Sprycel(r), and nilotinib, the Novartis drug known as Tasigna(r). Both have been approved by the U.S. Food and Drug Administration for use in CML patients whose disease becomes resistant to the frontline therapy imatinib, also a Novartis drug known as Gleevec(r), or who become intolerant to the drug.

Cortes and colleagues compared the two medications at 3, 6 and 12 months with historical data from patients who took either 400 mg or 800 mg daily of Gleevec.

For dasatinib, at three months 26 of 33 patients (79 percent) achieved complete cytogenetic response. At six months 30 of 32 (94 percent) and at 12 months all 24 evaluable patients were at a complete cytogenetic response.

For nilotinib, at three months 21 of 22 patients (95 percent) achieved complete cytogenetic response with all 13 evaluable patients at six months and all 11 at 12 months reaching complete cytogenetic response.

Historical complete cytogenetic responses for low-dose imatinib were 37
'/>"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Smoking may strongly increase long-term risk of eye disease
2. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
3. Family History Has Strong Effect on Cardiac Risk
4. Allied Healthcare Reports Strong Fourth Quarter, Flat Net Income for Fiscal 2007 vs. 2006
5. New Jersey Physicians Launch New, Statewide Association to Fight for Stronger Voice in Healthcare
6. Dynatronics Announces Strong Fourth Quarter Profit
7. New Survey Finds Strong Public Interest in Prescription Drug Safety Issues
8. Audio: New Survey Finds Strong Public Interest in Prescription Drug Safety Issues
9. Armstrong Kids Get in Step with Good Health
10. Chubby Checker Adds Twist to 10,000 Strong at Ninth Annual Walk to Cure Cancer for UMass Memorial Cancer Center at the UMass Medical School
11. Produce for Better Health Foundation Releases Statement on Study Saying Fruit & Vegetable Consumption Not Strongly Associated With Colon Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... July 24, 2014 The federal ... ) in the U.S. District Court, District ... for plaintiff medical information covered by the federal ... the July 16th Order, U.S. District Judge Douglas ... Fresenius Medical Care the right to receive HIPAA- ...
(Date:7/24/2014)... IL (PRWEB) July 24, 2014 In a ... infertility expert and founder of Lotus Blossom Consulting LLC ... Rosato entitled Three Ways to Cut the High Cost ... way to minimize costs is to maximize your chance of ... advice on choosing a clinic. , “I am always ...
(Date:7/24/2014)... of Association Executives (ASAE) announced its 2014 Power of ... American Society of Anesthesiologists (ASA). , The ASA ... A Gold Award, one of the top honors from ... of the world through education on the global anesthesia ... care. , ASA was also honored with a Power ...
(Date:7/24/2014)... Kathleen Doheny HealthDay Reporter ... children often don,t view their kids as unhealthy or recognize ... a new study. The children of the families surveyed ... the Hasbro Children,s Hospital in Providence, R.I. "A third ... study researcher Dr. Kyung Rhee, now an assistant professor of ...
(Date:7/24/2014)... Pools and beaches are the place to ... dangerous, especially for small children, so Amica Insurance ... to the Centers for Disease Control and Prevention, children between ... for water-related injuries and deaths. It’s important to know the ... Amica is offering the following tips from the American Red ...
Breaking Medicine News(10 mins):Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 2Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 3Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 4Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 2Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 3Health News:Parents of Obese Kids Often View Them as Healthy 2Health News:Parents of Obese Kids Often View Them as Healthy 3Health News:Keep Kids Safe in the Water with 5 Tips from Amica 2
... , MONDAY, Aug. 29 (HealthDay News) -- Kids who ... preschoolers to grow into adults who lack self-control, a ... there are some individuals who consistently presented as high ... cognitive neuroscientist at the Sackler Institute for Developmental Psychobiology ...
... of improved management at the acute stage, the risk ... decreased by about 50% in the past 10 years. ... hospital, has resulted in improved survival and fewer recurrent ... try and further decrease long-term mortality in patients who ...
... 30, 2011] Vaccinating infants against rotavirus also prevents serious disease ... by the Centers for Disease Control and Prevention (CDC). This ... results of the study are published in The Journal ... . Rotavirus is a major cause of severe diarrhea ...
... HealthDay Reporter , MONDAY, Aug. 29 (HealthDay News) -- ... and Armageddon. Current events have left adults reeling as ... the last with no relent and no apparent end in ... kids who are worriers, they see this stuff is everywhere," ...
... , MONDAY, Aug. 29 (HealthDay News) -- ... be hazardous business, a new study shows. It found ... of being hit at crosswalks, and listening to music is ... environment lab that simulated cars moving in multiple directions, more ...
... multidisciplinary educational programme in cardiovascular prevention directed to ... cardiovascular risk. Cardiovascular prevention could have more success ... in the whole family, "said investigator Luciana Fornari, ... inspiration for this study, presented today at the ...
Cached Medicine News:Health News:'Gimme' Kids Often Grow Into 'Gimme' Adults 2Health News:'Gimme' Kids Often Grow Into 'Gimme' Adults 3Health News:What do patients receiving optimal medical therapy after a heart attack die from? 2Health News:Rotavirus vaccination of infants also protects unvaccinated older children and adults 2Health News:For Kids, Natural Disasters Can Whip Up Worries 2Health News:For Kids, Natural Disasters Can Whip Up Worries 3Health News:Mobile Devices Dangerous for Pedestrians, Too 2Health News:How a cardiovascular prevention program in a Brazilian school reduced parent's CVD risk 2
(Date:7/24/2014)... , July 24, 2014 LSI Medience ... an Agreement with Kineticos, a Raleigh-Durham, ... Kineticos will support LSI Medience in identifying opportunities ... to demonstrate utility in clinical trials. ... utility in diagnosis of sepsis, prognosis of septic ...
(Date:7/24/2014)...  The American Association for Homecare (AAHomecare) yesterday ... help address audit issues in the HME industry ... the information technology lead in shaping its HME ... billing and business management solutions for nearly 3,000 ... support this important initiative on behalf of all ...
(Date:7/24/2014)... 24, 2014 Decision Resources Group finds that, ... countries ( France , Germany ... Spain and the United Kingdom ... first once-daily long-acting beta2 agonist/inhaled corticosteroid (LABA/ICS) fixed-dose combination ... Relvar as a first-line LABA/ICS FDC in the treatment ...
Breaking Medicine Technology:LSI Medience Corporation and Kineticos Sign Agreement Related to the Presepsin Biomarker in Sepsis Management and Treatment 2Brightree Joins AAHomecare as Corporate Partner and IT Lead on HME Audit Key 2Surveyed EU5 Pulmonologists Expect that Relvar, the First Once-Daily LABA/ICS FDC, Will Experience Healthy Uptake in Asthma 2Surveyed EU5 Pulmonologists Expect that Relvar, the First Once-Daily LABA/ICS FDC, Will Experience Healthy Uptake in Asthma 3
... Shire plc (LSE: SHP, NASDAQ: SHPGY ... on the approval status and availability of ProAmatine® (midodrine ... orthostatic hypotension (SOH).  Shire has engaged in consistent dialogue ... the past 12 months in the hopes of either ...
... 22, 2011 PediaVision, maker of the new Spot vision ... upgrading their PediaVision screening units to the new Spot vision ... into the Lions Clubs on-going screening program. Dr. Hauser Weiler, ... the Lions Clubs in 1987.  He has dedicated himself to ...
Cached Medicine Technology:Shire Provides Update on ProAmatine® (midodrine HCl) 2Shire Provides Update on ProAmatine® (midodrine HCl) 3Shire Provides Update on ProAmatine® (midodrine HCl) 4Lions Clubs of Virginia Acquire 8 New Spot Vision Screeners 2Lions Clubs of Virginia Acquire 8 New Spot Vision Screeners 3Lions Clubs of Virginia Acquire 8 New Spot Vision Screeners 4
Sera available in three levels for the control of accuracy and precision for up to 31 analytes...
Human based material available in two levels for the control of accuracy and precision for upto 23 analytes....
CRP Liquid Conrtols level 3...
The GLU method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of glucose in serum, plasma, urine and cerebrospinal fluid....
Medicine Products: