Navigation Links
Dartmouth study uses the patient's tumor to form vaccine
Date:11/24/2010

A new process for creating a personalized vaccine may become a crucial tool in helping patients with colorectal cancer develop an immune response against their own tumors. This dendritic cell (DC) vaccine, developed at Dartmouth and described in a research paper published this week in the journal Clinical Cancer Research, was used after surgical resection of metastatic tumors to try to prevent the growth of additional metastases.

"The results of the study suggest a new way to approach cancer treatment," said Richard Barth Jr., MD, Chief of General Surgery at Dartmouth-Hitchcock Medical Center and a member of the Gastrointestinal Clinical Oncology Group at Dartmouth-Hitchcock Norris Cotton Cancer Center, who is the study's principal investigator. "Basically, we've worked out a way to use dendritic cells, which initiate immune responses, to induce an antitumor response."

Dendritic cells are critical to the human body's immune system, helping identify targets, or antigens, and then stimulating the immune system to react against those antigens. The new research grew dendritic cells from a sample of a patient's blood, mixed them with proteins from the patient's tumor, and then injected the mixture into the patient as a vaccine. The vaccine then stimulated an anti-tumor response from T-cells, a kind of white blood cell that protects the body from disease.

In the study, Barth first operated on 26 patients to remove tumors that had spread from the colon to the liver. While some of these patients would be expected to be cured with surgery alone, most of them would eventually die from tiny metastases that were undetectable at the time the tumors were removed from the liver. The DC vaccine treatment was given one month after surgery. The results were that T-cell immune responses were induced against the patient's own tumor in more than 60% of the patients. The patients were followed for a minimum of 5.5 years. Five years after their vac
'/>"/>

Contact: Steven P. Bjerklie
steven.p.bjerklie@dartmouth.edu
603-653-9056
Dartmouth-Hitchcock Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... to use a laser to measure people,s blood sugar, ... to a portable size, the technique could allow diabetics ... blood. , "We are working hard to turn engineering ... their daily lives," said Claire Gmachl, the Eugene Higgins ... "With this work we hope to improve the lives ...
(Date:8/21/2014)... a genetically engineered line of mice that is expected ... Alzheimer,s and other diseases. , The mice carry ... in response to different calcium levels. This will allow ... to be studied in a new way. , "This ... brain works," said Petr Tvrdik, Ph.D., a research ...
(Date:8/21/2014)... 21, 2014 Entries are now open ... only comprehensive national awards program totally dedicated to recognizing ... and executive leadership. The entry deadline is Oct. 17. ... Estate Insights™, the first and only national magazine entirely ... investment. , “We launched the HREI Insights Awards program ...
(Date:8/21/2014)... Aug. 21, 2014 (HealthDay News) -- Black Americans are ... racial groups battling the blood sugar disease, a new ... National Health and Nutrition Examination Survey, which evaluates about ... the highest rates of a condition known as diabetic ... blindness in people with diabetes. Diabetic macular edema ...
(Date:8/21/2014)... According to the new report “Waterborne Coatings ... PTFE, PVDF, PVDC, & Others), by Application (Architectural, ... & Others) - Global Forecast to 2019” published ... estimated to reach $77,838.71 Million by 2019. , ... spread through 225 Slides and in-depth TOC on ...
Breaking Medicine News(10 mins):Health News:Laser device may end pin pricks, improve quality of life for diabetics 2Health News:Laser device may end pin pricks, improve quality of life for diabetics 3Health News:Mouse model for epilepsy, Alzheimer's gives window into the working brain 2Health News:Entries Open for 2014 HREI Insights Awards™ 2Health News:Entries Open for 2014 HREI Insights Awards™ 3Health News:Entries Open for 2014 HREI Insights Awards™ 4Health News:Blacks May Face Higher Risk of Diabetes-Linked Vision Loss 2Health News:Waterborne Coatings Market worth $77,838.71 Million by 2019 – New Report by MarketsandMarkets 2Health News:Waterborne Coatings Market worth $77,838.71 Million by 2019 – New Report by MarketsandMarkets 3Health News:Waterborne Coatings Market worth $77,838.71 Million by 2019 – New Report by MarketsandMarkets 4
... Ohio State University Medical Center Implants Two Patients ... Clinical TrialSYDNEY, and TUSTIN, Calif., April 21 Sunshine ... on innovative heart assist technologies, announced today that The ... Ohio has successfully completed the first two implants of ...
... Aethlon Medical, Inc. (OTC Bulletin Board: AEMD), ... device to treat infectious disease, today announced ... to lead its investor relations outreach programs. ... first medical device that can selectively remove ...
... Extend National Diabetes Awareness Campaign in Six Additional CitiesBRIDGEWATER, ... star Ben Vereen will reprise his role as a ... Diabetes Awareness with sanofi-aventis U.S. to share his ... extend the national campaign he kicked off in September ...
... site to help raise awareness of deadliest form of ... of Skin Cancer Awareness Month and the increasing incidence ... Society for Dermatologic Surgery (ASDS) has created a free ... Facebook site. The kit and site were created to ...
... cord injuries much more common than thought , , TUESDAY, April ... million people, live with some form of paralysis, a new ... now, said Joseph Canose, vice president of quality of life ... survey Tuesday. The foundation was created by the late actor ...
... Money-Saving Options Now Available through Schiff(R) Loyalty RewardsSALT LAKE ... the most trusted and respected brands in the nutritional ... Schiff(R) Loyalty Rewards. The new incentive program offers ... Schiff(R) Glucosamine product purchased (at participating retailers). These ...
Cached Medicine News:Health News:First Patients in United States Receive Innovative Device to Treat Moderate Heart Failure 2Health News:First Patients in United States Receive Innovative Device to Treat Moderate Heart Failure 3Health News:First Patients in United States Receive Innovative Device to Treat Moderate Heart Failure 4Health News:Aethlon Medical Announces Engagement of RedChip Companies to Initiate Investor and Media Relations Programs 2Health News:Aethlon Medical Announces Engagement of RedChip Companies to Initiate Investor and Media Relations Programs 3Health News:Video: American Performing Icon Ben Vereen Encourages People to 'Take the Stage' and Act on Their Diabetes in 2009 2Health News:Video: American Performing Icon Ben Vereen Encourages People to 'Take the Stage' and Act on Their Diabetes in 2009 3Health News:Video: American Performing Icon Ben Vereen Encourages People to 'Take the Stage' and Act on Their Diabetes in 2009 4Health News:The ASDS Introduces the First At-Home Skin Cancer Exam Kit 2Health News:One in 50 Americans Lives With Paralysis 2Health News:One in 50 Americans Lives With Paralysis 3Health News:Schiff(R) Unveils Loyalty Program to Reward Valued Customers 2
(Date:8/21/2014)... Mass. , Aug. 21, 2014  Decision ... COPD,  physicians in Brazil ... follow clinical guidelines and commonly prescribe long-acting beta-agonist ... although they do so within current severe cost/coverage ... (FDCs) that are expected to launch in these ...
(Date:8/21/2014)...  Zacks.com announces the list of stocks featured in the ... the latest news and events impacting stocks and the financial ... HPQ - Free Report ), IBM (NYSE: IBM ... - Free Report ), GlaxoSmithKline plc (NYSE: GSK - ... - Free Report ). Today, Zacks is promoting ...
(Date:8/21/2014)... N.J. , Aug. 21, 2014  Armada ... group purchasing organization (GPO), is pleased to announce ... collaborate on a host of innovative specialty pharmacy ... Aurora deliver enhanced therapy management services to specialty ... (OTM) system. Aurora will use the ...
Breaking Medicine Technology:Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 2The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 3The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 4The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 5The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 6The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 7The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 8The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 9The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 10The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 11Aurora Health Care Partners with Armada Health Care to Deliver Added Pharmacy Capabilities to Specialty Patients 2Aurora Health Care Partners with Armada Health Care to Deliver Added Pharmacy Capabilities to Specialty Patients 3
... June 22, 2011 CardioGenics Holdings Inc. (CGNH.OB) ... business unit, which develops ultra sensitive magnetic beads ... subsidiary, Luxspheres Inc. The beads business unit, which ... Inc. Canadian subsidiary ("CardioGenics"), will now be operated ...
... Lighting has developed, tested, and confirmed by independent testing ... bare or gloved hands safely and quickly, achieves -6log10 ... difficile spores. It has developed a simple, proprietary ... of gloved or bare hands is implemented within a ...
Cached Medicine Technology:CardioGenics Transfers Magnetic Beads Business Unit Into its Luxspheres Inc. Subsidiary 2CardioGenics Transfers Magnetic Beads Business Unit Into its Luxspheres Inc. Subsidiary 3Germgard Lighting Demonstrates Two-Second, Bare and Gloved Hand Sterilization 2Germgard Lighting Demonstrates Two-Second, Bare and Gloved Hand Sterilization 3
Data review and analysis is carried out with the Acquidata Uromac software already supplied with Acquidata Uromac Lab based urodynamics systems...
... TT™ offers the ultimate research level wireless ... knowledgeable clinician and researcher today. Offering superb ... to meet your desired footprint requirements. Choose ... display live data both in the room ...
... diagnostic capabilities combined with ease of use ... in its class. Ideal for office or ... system for Uroflowmetry, cystometry, leak point pressure, ... are available which make the OM-5 flexible ...
... diagnostic capabilities combined with ease of use ... in its class. Ideal for office or ... system for Uroflowmetry, cystometry, leak point pressure, ... are available which make the OM-5 flexible ...
Medicine Products: