Navigation Links
Dartmouth scientists identify genetic blueprint for cancerous tumors of the appendix
Date:5/12/2014

Using next generation DNA sequencing, Dartmouth scientists have identified potentially actionable mutations in cancers of the appendix. Their study, "Molecular Profiling of Appendiceal Epithelial Tumors Using Massively Parallel Sequencing to Identify Somatic Mutations," was published in the journal Clinical Chemistry today. When specific mutations for a cancer type are identified, patients can be treated with chemotherapy or other targeted agents that work on those mutations.

Little is known about the molecular biology of two types of appendix tumors, low-grade appendiceal mucinous neoplasm (LAMN) and adenocarcinoma, but both can lead to pseudomyxoma peritonea (PMP), a critical condition in which cancerous cells grow uncontrollably along the wall of the abdomen and can crush digestive organs.

Dartmouth pathologists studied 38 specimens of LAMN and adenocarcinoma tumors (some of which had progressed to PMP) from their archives to look for shared genetic errors that might be responsible for the abnormal cell growth. Tissue samples were sequenced using the AmpiSeq Hotspot Cancer Panel v2, which pathologists had verified for the clinical screening of mutations in 50 common cancer-related genes for which treatments exist. This was the first study making use of a multigene panel in appendiceal cancers to support the use of potential targeted therapies.

"We routinely use this molecular profiling approach on all of our lung adenocarcinomas, melanomas, colon cancers, and gliomas," said Gregory Tsongalis, PhD, principal investigator for the study and director of Molecular Pathology at Dartmouth-Hitchcock Norris Cotton Cancer Center. He says examining an individual tumor profile has the potential to significantly alter patient outcome in a positive way.

KRAS and GNAS mutations were the most common alterations identified in the study. Twelve distinct abnormalities were mapped to the KRAS gene. Additional mutations were identifi
'/>"/>

Contact: Robin Dutcher
Robin.dutcher@hitchcock.org
603-653-9056
The Geisel School of Medicine at Dartmouth
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Anti-smoking TV ads should use anger, Dartmouth-Cornell study suggests
2. Dartmouth awarded lead role in NCI clinical trials network
3. Dartmouth researchers develop new approach to chronic lymphocytic leukemia treatment
4. Dartmouth study provides first global evidence that foreign aid boosts public opinion
5. Dartmouth researcher finds novel genetic patterns that make us rethink biology and individuality
6. Clemson, Dartmouth use $1.5M grant to develop mobile health technology
7. Dartmouth researchers receive $5.9 million grant from NIH for lung research
8. Dartmouth researchers develop molecular switch that changes liquid crystal colors
9. Dartmouth researchers test safety of Nivolumab in kidney cancer
10. Leap in leukemia treatment reported by Dartmouth researchers
11. Dartmouth medical research closes in on new tuberculosis vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... The Biofeedback Federation of Europe annual meeting ... Rome, Italy and is hosted by the Salesian Pontifical ... a wide variety of topics such as ADHD, anxiety, ... in athletes. The scientific program will feature the latest ... allows clients to see what is going on in ...
(Date:12/26/2014)... 26, 2014 DW-InductionHeating.com (DaWei Induction Heating ... researching and developing, producing and marketing of a series ... business announces their new series of induction brazing ... the company, induction brazing refers to the ... filler material and heat. The manager says that there ...
(Date:12/25/2014)... 2014 The report “Nintedanib (Colorectal ... focuses on the current treatment landscape, unmet needs, ... cancer market. Stivarga is a drug which is ... cancer. Boehringer Ingelheim is developing nintedanib (BIBF-1120), an ... refractory CRC in the US, Europe, and Japan. ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online ... its collection of discounted prom dresses, most of which ... spokesman of the company, the promotion is valid until ... to expand the UK market. , The prom dresses ... lengths, and styles: A-line strapless, empire strapless chiffon, one ...
(Date:12/25/2014)... 25, 2014 When head lice hits a ... a frenzy to get rid of it while keeping it ... Coral Gables now have the solution right in their neighborhood: ... location, Lice Troopers provides full spectrum head lice screening and ... area, including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest ...
Breaking Medicine News(10 mins):Health News:Final Workshop Line-up Announced for 18th Annual Biofeedback Conference in Rome, Italy 2Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2
... TITUSVILLE, N.J., Dec. 12 INVEGA(TM) (paliperidone),Extended-Release ... a one-year open-label extension (OLE) study, according ... symptom scores improved or,were stable, on average, ... was designed to evaluate the long-term safety ...
... got to do it. Hair Fairies - The Head Lice, Helpers - ... only ... CHICAGO, Dec. 12 No two words in the English language,can stop ... care centers, and other kid-centric services are often,sent into crisis mode when ...
... ATS Medical, Inc.,(Nasdaq: ATSI ), manufacturer and ... announced that James L. Cox, M.D. has,agreed to ... reputation as a,preeminent authority in the surgical treatment ... as the foundation for ATS 3f(R),tissue valve technologies, ...
... Sysmex America, Inc. today,announced that its Sysmex XE-5000 ... States Food and Drug Administration (FDA) for sale ... high throughput,analyzer that provides 31 whole blood reportable ... specific mode. The Sysmex,XE-5000 will be available in ...
... Zimmer Holdings, Inc.,(NYSE: ZMH ; SWX: ZMH), a ... Approval (PMA) application for the Zimmer(R),NexGen(R) LPS-Flex Mobile Knee ... "A number of orthopaedic surgeons prefer mobile bearing designs ... companies that can offer this treatment,option in the U.S.," ...
... Gift Supports Home Front Needs of Families with Deployed Service Members ... ... Dec. 11 As the exclusive sponsor of the,Military Child Education Coalition,s ... in Seattle,TriWest Healthcare Alliance will present $25,000 to the Minuteman Emergency,Assistance Fund. ...
Cached Medicine News:Health News:INVEGA(TM) Shows Favorable Long-Term Safety Profile in a One-Year Study of Patients With Schizophrenia 2Health News:INVEGA(TM) Shows Favorable Long-Term Safety Profile in a One-Year Study of Patients With Schizophrenia 3Health News:INVEGA(TM) Shows Favorable Long-Term Safety Profile in a One-Year Study of Patients With Schizophrenia 4Health News:INVEGA(TM) Shows Favorable Long-Term Safety Profile in a One-Year Study of Patients With Schizophrenia 5Health News:INVEGA(TM) Shows Favorable Long-Term Safety Profile in a One-Year Study of Patients With Schizophrenia 6Health News:Head Lice Removal Service Opens in Chicago 2Health News:Head Lice Removal Service Opens in Chicago 3Health News:ATS Medical Appoints James L. Cox, M.D. as Medical Director 2Health News:ATS Medical Appoints James L. Cox, M.D. as Medical Director 3Health News:Sysmex America Receives FDA Clearance for XE-5000(TM) Hematology Analyzer 2Health News:Zimmer Holdings Receives FDA Approval to Market Mobile Bearing Knee 2Health News:Zimmer Holdings Receives FDA Approval to Market Mobile Bearing Knee 3Health News:Zimmer Holdings Receives FDA Approval to Market Mobile Bearing Knee 4Health News:TriWest Contributes $25,000 to Washington National Guard Fund and Sponsors Education for Teachers of Military Children 2
(Date:12/24/2014)... 24, 2014 /CNW/ -   ... after Health Canada tests confirmed it contains two undeclared ... and phenylpropylmethylamine). The distributor, Empire Health Distribution of ... from retail stores across Canada . ... for weight loss and increased energy. ...
(Date:12/24/2014)... BUFFALO, N.Y. , Dec. 24, 2014 ... been dosed with KX2-361 at Roswell Park Cancer Institute. ... a small molecule drug that has shown potent inhibitory ... lines, including those that are resistant to Temozolomide (T98G), ... malignant glioma. In a well-established brain tumor mouse model, ...
(Date:12/24/2014)... FARMINGTON, Conn. , Dec. 24, 2014 ... a biopharmaceutical company developing targeted, receptor-specific peptide therapeutics ... medical need and commercial potential, today announced that ... 2,050,000 shares of its common stock and Series ... common stock.  Funds under the management of QVT ...
Breaking Medicine Technology:"Jetfuel Superburn" recalled after Health Canada tests find undeclared drug ingredients 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4
Lightweight PVC housing for easy transport, integrated handle. Easy lamp exchange....
... important diagnostic tool in determining functionality ... important when deciding courses of treatment ... treatment, recurring infections and autoimmune dieseases. ... patients with autoimmune diseases giving rise ...
Maximum brightness, durability, universal power suply, microprocessor-controlled light output and, in the event of lamp failure or degredation, automatic switchover to an integraged spare lamp....
Tested by surgeons for functionality and ergonomy. Uses the Medifix C3-3001-3CCD camera head....
Medicine Products: