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Dartmouth medical research closes in on new tuberculosis vaccine
Date:8/23/2012

effective in healthy populations." Consequently, much of his research and testing has been in Africa, generating longstanding working relationships with colleagues in Tanzania.

The vaccine was originally developed as a drug to regulate immune system activity in the treatment of cancer and allergies. This work was carried out under SR Pharma, a predecessor company to London-based Immodulon Therapeutics Ltd., von Reyn's current collaborator. The vaccine is produced by growing bacteria related to TB (Mycobacterium vaccae) on agar plates, harvesting the bacteria, and then inactivating the bacteria with heat.

A large, randomized controlled trial of the vaccine began in 2001 in Tanzania, funded by the National Institutes of Health. It involved more than 2,000 HIV-infected subjects, each receiving five doses of the vaccine. The results demonstrated that immunization reduced the rate of tuberculosis among HIV-infected patients by 39 percenta statistically significant reduction.

"The research that Professor von Reyn and his colleagues are doing is emblematic of our commitment to global health and engagement at Geisel," says Wiley "Chip" Souba, dean of The Geisel School of Medicine. "Our partnerships with Muhimbili University are enabling this pursuit of a new tuberculosis vaccine, as well as collaborative programs in TB- and HIV/AIDS-related hearing impairment, nutrition, and pediatric care and treatment."

While the study demonstrated the effectiveness of the vaccine, a more efficient process is necessary to scale up production. So von Reyn and Immodulon began a relationship with the Aeras Global TB Vaccine Foundation in Rockville, Md. Using its manufacturing facilities to grow the vaccine in large broth fermenters rather than on small agar plates, Aeras succeeded in developing a new manufacturing method suitable for producing large quantities of the vaccine.

To move forward with the broth-produced vaccine, von Reyn and his col
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Contact: Amy Olson
amy.d.olson@dartmouth.edu
603-646-3661
Dartmouth College
Source:Eurekalert  

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