Navigation Links
Danish scientists solve old blood mystery
Date:8/31/2012

Scientists at the research centre MEMBRANES at Aarhus University, Denmark, have completed an old puzzle, which since the 60s from many sides has been regarded as impossible to complete. The challenge was to solve the structure of the protecting protein complex that forms when haemoglobin is released from red cells and becomes toxic. This toxic release of haemoglobin occurs in many diseases affecting red cell stability, e.g. malaria.

Technically, the most important finding in this report in Nature is a high-resolution three-dimensional mapping of the so-called 'haptoglobin-haemoglobin complex'.

"After many failing experiments, our breakthrough came when we gave up using human material and went to the local slaughterhouse to purchase pig blood. Not a particular high-technological approach, but this transition from studying human blood to blood from a species with close homology had magic effects. After running into dead ends for two years and trying out the most complex gene-technological ways to produce the right material, it suddenly worked", says Sren Kragh Moestrup, the head of the research group at Department of Biomedicine.

The discovery provides new essential information on haemoglobin that makes up most of the red cell interior. Haemoglobin is an essential blood component for transport of oxygen, but it becomes toxic with potential damaging effects on tissues, in particular the kidneys, when it is released from the red cells. An excessive release can occur in many diseases, such as malaria and other infections.

However, the body has a sophisticated defence system. The first line defence is carried out by the blood protein haptoglobin, which captures haemoglobin and gates it to a receptor that engulfs the haemoglobin-haptoglobin complex. This function of the receptor named CD163 was originally discovered by the same group.

"We have now shown how this unique protein complex forms by generation of a detailed 3-dimensional map of each atom. This shows for the first time how the complex is formed and explains the tight protein association", says PhD Christian Brix Folsted Andersen. He has together with Master's student Morten Torvund-Jensen been an essential driving force in the project.

The results have also led to an unexpected discovery of a novel type of protein structure and a new patent submission on exploitation of the discovery for use in generation of a new type of synthetic proteins to be used in therapy and diagnostics.


'/>"/>

Contact: Soeren Kragh Moestrup
skm@biokemi.au.dk
(45) 28-99-22-82
Aarhus University
Source:Eurekalert

Related medicine news :

1. Danish scientists detect new immune alert signal
2. First validated method for analyzing flavanols and procyanidins in cocoa products could help scientists and the industry in standardized reporting
3. Scientists ID Happy Gene in Women
4. NIH scientists map first steps in flu antibody development
5. Scientists to design drug for chronic pain
6. Scientists from UCLA, Israels Technion uncover brains code for pronouncing vowels
7. Scientists ID Cancer-Causing Agent in Smokeless Tobacco
8. UCSB scientists examine effects of manufactured nanoparticles on soybean crops
9. Scientists report promising new direction for cognitive rehabilitation in the elderly
10. Scientists to investigate preventing life-threatening complications in transplant patients
11. Scientists decode TREX which could see new treatments for cancer realized
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/7/2016)... Metamora, Michigan (PRWEB) , ... February 07, 2016 , ... ... recognition of National Wear Red Day. National Wear Red Day is the first ... in women. Heart disease and stroke cause 1 in 3 deaths among women each ...
(Date:2/6/2016)... ... February 06, 2016 , ... With the FCPX LUT: Summer pack ... their footage. A LUT is a Lookup Table that contains a mathematical formula for ... by the table. By manipulating each pixel, LUT's can change each color range differently, ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... company's lighter, sleeker next generation LYNX VR Indoor Trainer with multi-rider capability to ... design and manufacturing not only reduce the weight of the unit, they also ...
(Date:2/5/2016)... ... February 05, 2016 , ... Francisco Canales, MD and Heather ... Napa Valley office. The technique utilizes the body’s own healing abilities to quickly ... Furnas, are part of only a select few cosmetic surgeons bringing this procedure ...
(Date:2/5/2016)... ... February 05, 2016 , ... US Sports Camps , official ... NH to direct high-performance kids yoga training. ChildLight Yoga Studio is centrally situated in ... from Boston. , ChildLight Yoga Studio founder Lisa Flynn expresses her excitement, “We are ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)...  As people age, it is natural to be ... and tests that are linked with certain age milestones ... majority of aging individuals, hearing health is too frequently ... million American adults who report some trouble hearing, there ... health a 2016 healthy aging priority.[1] Cochlear ...
(Date:2/5/2016)... VENICE, Fla. , Feb. 5, 2016 /PRNewswire/ ... Centers , is the first of its kind ... of undesired tattoos through advanced laser treatment. The ... Florida,s Suncoast by storm with ... video consultations, and advanced multi-wavelength Astanza Trinity technology. ...
(Date:2/5/2016)... MELVILLE, N.Y. , Feb. 5, 2016  Henry ... of health care products and services to office-based dental, ... has entered into an agreement to acquire a majority ... dental supplies and equipment in Brazil ... Headquartered in Blumenau, Brazil, Dental Cremer is the dental ...
Breaking Medicine Technology: