Navigation Links
Danish scientists solve old blood mystery
Date:8/31/2012

Scientists at the research centre MEMBRANES at Aarhus University, Denmark, have completed an old puzzle, which since the 60s from many sides has been regarded as impossible to complete. The challenge was to solve the structure of the protecting protein complex that forms when haemoglobin is released from red cells and becomes toxic. This toxic release of haemoglobin occurs in many diseases affecting red cell stability, e.g. malaria.

Technically, the most important finding in this report in Nature is a high-resolution three-dimensional mapping of the so-called 'haptoglobin-haemoglobin complex'.

"After many failing experiments, our breakthrough came when we gave up using human material and went to the local slaughterhouse to purchase pig blood. Not a particular high-technological approach, but this transition from studying human blood to blood from a species with close homology had magic effects. After running into dead ends for two years and trying out the most complex gene-technological ways to produce the right material, it suddenly worked", says Sren Kragh Moestrup, the head of the research group at Department of Biomedicine.

The discovery provides new essential information on haemoglobin that makes up most of the red cell interior. Haemoglobin is an essential blood component for transport of oxygen, but it becomes toxic with potential damaging effects on tissues, in particular the kidneys, when it is released from the red cells. An excessive release can occur in many diseases, such as malaria and other infections.

However, the body has a sophisticated defence system. The first line defence is carried out by the blood protein haptoglobin, which captures haemoglobin and gates it to a receptor that engulfs the haemoglobin-haptoglobin complex. This function of the receptor named CD163 was originally discovered by the same group.

"We have now shown how this unique protein complex forms by generation of a detailed 3-dimensional map of each atom. This shows for the first time how the complex is formed and explains the tight protein association", says PhD Christian Brix Folsted Andersen. He has together with Master's student Morten Torvund-Jensen been an essential driving force in the project.

The results have also led to an unexpected discovery of a novel type of protein structure and a new patent submission on exploitation of the discovery for use in generation of a new type of synthetic proteins to be used in therapy and diagnostics.


'/>"/>

Contact: Soeren Kragh Moestrup
skm@biokemi.au.dk
(45) 28-99-22-82
Aarhus University
Source:Eurekalert

Related medicine news :

1. Danish scientists detect new immune alert signal
2. First validated method for analyzing flavanols and procyanidins in cocoa products could help scientists and the industry in standardized reporting
3. Scientists ID Happy Gene in Women
4. NIH scientists map first steps in flu antibody development
5. Scientists to design drug for chronic pain
6. Scientists from UCLA, Israels Technion uncover brains code for pronouncing vowels
7. Scientists ID Cancer-Causing Agent in Smokeless Tobacco
8. UCSB scientists examine effects of manufactured nanoparticles on soybean crops
9. Scientists report promising new direction for cognitive rehabilitation in the elderly
10. Scientists to investigate preventing life-threatening complications in transplant patients
11. Scientists decode TREX which could see new treatments for cancer realized
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 27, 2016 , ... TherapySites, the leading website ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to ... adding exclusive benefits and promotional offers. , "TCA is extremely excited about this ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution ... the emergency ambulance transport experience for the millions of people who require these ... disrupted the taxi industry through the use of technology. Now, SmartEMS has put ...
(Date:6/26/2016)... PLAINSBORO, N.J. (PRWEB) , ... June 27, 2016 , ... ... same sources, yet in many ways they remain in the eye of the beholder, ... Oncology (EBO), a publication of The American Journal of Managed Care. For the full ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a ... can give their videos a whole new perspective by using the title layers ... Film Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/26/2016)... NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and ... to be personalized through a fitness app. The fitness app plans to fix the two ... currently only offer a one size fits all type program , They don’t ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Mass. , June 24, 2016   ... Spaulding Rehabilitation Network,s Dean Center for Tick ... Physical Medicine and Rehabilitation, MIT Hacking Medicine, University ... for Innovation, today announced the five finalists of ... for Lyme disease.  More than 100 scientists, clinicians, ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June ... -based mobile pulmonary function testing company, is now able to ... devices developed by ndd Medical Technologies , Inc. ... done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ... , can get any needed testing done in the comfort of ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
Breaking Medicine Technology: